• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 2 votes

young blood has major rejuvenating effects

longevity

  • Please log in to reply
8 replies to this topic

#1 GABAergic

  • Guest
  • 326 posts
  • -81
  • Location:Maine

Posted 21 June 2019 - 10:50 PM


not news, its been talked about for a while. i just got back to it after reading another recent article on this; https://medicalxpres...oung-blood.html

im considering this though for various conditions. for example, if someone young donates blood and i have it in me, do you guys think it will help rejuvenate me?? also how young is considered most suitable for such thing. obviously its not ethical to have a kid donate blood so i can use, but perhaps a teen is fine too?



#2 Phoebus

  • Guest
  • 659 posts
  • 142
  • Location:Upper Midwest, US

Posted 21 June 2019 - 10:57 PM

How would you even get it done? The only company offering it has been shut down as far as I know. 

 

 



To book this BIOSCIENCE ad spot and support Longecity (this will replace the google ad above) - click HERE.

#3 GABAergic

  • Topic Starter
  • Guest
  • 326 posts
  • -81
  • Location:Maine

Posted 21 June 2019 - 11:01 PM

there was a company offering this service? wow. i missed out i guess.

well, its not simple really. but when i think about this, you do realize there are blood donation centers right? well, imagine some of those places have young healthy people donate and i get their blood. not sure how to control this yet though. its not like i can choose, or maybe i can? i would just have to have a good reason to get blood transfusion is all and then ill figure out how to get specific type of blood in me. it going to be work, but i believe in this as major life quality enhancing idea.

anyway if you guys have any ideas to throw out, please do. im all ears!


Edited by GABAergic, 21 June 2019 - 11:01 PM.


#4 QuestforLife

  • Member
  • 663 posts
  • 289
  • Location:UK

Posted 24 June 2019 - 08:50 AM

It appears that the benefits of young blood plasma are dependent on autophagy, atleast in rats as reported here:

 

https://www.ncbi.nlm...les/PMC5770779/

 


 

SUMMARY
Recent studies showing the therapeutic effect of young blood on aging‐associated deterioration of organs point to young blood as the solution for clinical problems related to old age. Given that defective autophagy has been implicated in aging and aging‐associated organ injuries, this study was designed to determine the effect of young blood on aging‐induced alterations in hepatic function and underlying mechanisms, with a focus on autophagy. Aged rats (22 months) were treated with pooled plasma (1 ml, intravenously) collected from young (3 months) or aged rats three times per week for 4 weeks, and 3‐methyladenine or wortmannin was used to inhibit young blood‐induced autophagy. Aging was associated with elevated levels of alanine transaminase and aspartate aminotransferase, lipofuscin accumulation, steatosis, fibrosis, and defective liver regeneration after partial hepatectomy, which were significantly attenuated by young plasma injections. Young plasma could also restore aging‐impaired autophagy activity. Inhibition of the young plasma‐restored autophagic activity abrogated the beneficial effect of young plasma against hepatic injury with aging. In vitro, young serum could protect old hepatocytes from senescence, and the antisenescence effect of young serum was abrogated by 3‐methyladenine, wortmannin, or small interfering RNA to autophagy‐related protein 7. Collectively, our data indicate that young plasma could ameliorate age‐dependent alterations in hepatic function partially via the restoration of autophagy.

 

So this links the benefits of CR, intermittent fasting, rapamycin, glucosamine, etc., to young blood. It is likely that when you mix your blood with younger blood, you get more favourable conditions for the upregulation of autophagy.



#5 Mind

  • Life Member, Moderator, Secretary
  • 16,202 posts
  • 2,001
  • Location:Wausau, WI

Posted 24 June 2019 - 09:26 AM

The scientific term is parabiosis. "Ambrosia" was the company offering this service. Not sure whether or not they are still operating:

 

https://www.business...ambrosia-2017-1

 

https://www.longecit...tion-of-damage/

 

https://www.longecit...venation-trial/

 

 



#6 QuestforLife

  • Member
  • 663 posts
  • 289
  • Location:UK

Posted 25 June 2019 - 02:01 PM

The scientific term is parabiosis.

 

Actually parabiosis is, I believe, when two unfortunate animals of differing ages have their circulatory systems stitched together.  So they share everything that's in the blood.

 

Young plasma is the cell free part of blood that supposedly contains rejuvenating factors.


  • Good Point x 1

Click HERE to rent this BIOSCIENCE adspot to support LongeCity (this will replace the google ad above).

#7 Mind

  • Life Member, Moderator, Secretary
  • 16,202 posts
  • 2,001
  • Location:Wausau, WI

Posted 26 June 2019 - 04:48 PM

Actually parabiosis is, I believe, when two unfortunate animals of differing ages have their circulatory systems stitched together.  So they share everything that's in the blood.

 

Young plasma is the cell free part of blood that supposedly contains rejuvenating factors.

 

Yes, that is more correct.

 

Thanks for pointing out my oversight/misstatement.


  • like x 1

#8 Bruce Klein

  • Guardian Founder
  • 8,750 posts
  • 222
  • Location:United States

Posted 27 June 2019 - 12:20 PM

According the Feb 2019 NBC article, Ambrosia “ceased patient treatments" in the United States after the FDA Commissioner Scott Gottlieb, M.D. (with others) issued a joint statement warning consumers there is no evidence for treating various conditions with young donor plasma. 

 

However, as Mind suggest, not sure if Jesse Karmazin (Ambrosia CEO) continues to do this in the US or other parts of the world, as their website still has the offering -- 1 liter for $8k and 2 liters for $12k. 

 

https://www.ambrosiaplasma.com/

 

https://www.nbcnews....warning-n973266

 

https://www.fda.gov/...valuation-and-0



To book this BIOSCIENCE ad spot and support Longecity (this will replace the google ad above) - click HERE.

#9 GABAergic

  • Topic Starter
  • Guest
  • 326 posts
  • -81
  • Location:Maine

Posted 28 June 2019 - 06:42 PM

wow its really expensive. cant i just get young blood plasma without dealing with third party? i mean, i can find a young donor, he can donate for me and i get the blood. of course ill pay him/her for it. teenagers do need money after all. it shouldnt be difficult :)







Also tagged with one or more of these keywords: longevity

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users