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[Harkijn]

An interesting paper on increased mitochondrial clearance in mice by means of supplementing NR.

 

Abstract

It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here we show that the NAD+-boosting agent nicotinamide riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions. NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80%, and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation. In immune-deficient mice, NR increased the production of human leucocytes from hCD34+ progenitors. Our work demonstrates for the first time a positive effect of NAD+-boosting strategies on the most primitive blood stem cells, establishing a link between HSC mitochondrial stress, mitophagy, and stem-cell fate decision, and unveiling the potential of NR to improve recovery of patients suffering from hematological failure including post chemo- and radiotherapy.

 

https://www.ncbi.nlm...pubmed/30849366

 

Edited by Harkijn, 29 June 2019 - 03:04 PM.

[Harkijn]

The mice were fed 12 mg NR per day in their food.

Interestingly two types of NR were used: Niagen and a custom made NR triflate. Though both had positive effects the triflate scored markedly better.

 I have only a very basic knowledge of what a triflate is. Perhaps one of you might speculate on the differences in outcome between the two?