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Cancer cured by common cold

cancer fever c60 macrophage infection

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#1 QuestforLife

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Posted 05 July 2019 - 07:19 AM


https://www.telegrap...trial-suggests/

The common cold virus could cure cancer, scientists say, as a “revolutionary” treatment was found to eradicate the disease in a week.

In the pioneering British trial, 15 patients were given an infusion of the bug, before undergoing surgery to remove and examine tumours.

In every case, cancer cells had been destroyed - and in one case, all traces of the disease had gone, the study found.

Scientists said they were “very excited” about the findings, for patients with bladder cancer, which could also bring hope to those suffering from other major forms of the disease.

They said the virus could become a “universal agent” to fight cancer, replacing conventional treatments like chemotherapy.

As well as reducing the size of all the tumours, the treatment, via a catheter to the bladder, had no significant side-effects in any of the patients, researchers said.

Bladder cancer is the tenth most common type of cancer in the UK, with 10,000 diagnoses annually.

Scientists said they hoped the treatment could be available in as little as three years, bringing hope to thousands of patients with diseases that are currently hard-to-treat.

Most tumours in the bladder do not have immune cells, making the disease particularly hard to treat.


But the study suggests that an infusion of a strain of the common cold virus - called coxsackievirus (CVA21) - was able to inflame the tumour and cause immune cells to rush into the cancer environment, targeting and killing the cancer cells.


Scientists said once the virus targeted the cancer, it replicated itself, making its effects even more powerful.

Prof Hardev Pandha, Principal Investigator of the study and Professor of Medical Oncology at the University of Surrey, said: “We are very excited about it. The virus gets into the cancer and replicates, like a little factory of viruses. It heats up the tumour environment, and is very specific in targeting the cancer - it had the least toxicity I have seen for years.”

It comes as other trials examine the role of common cold viruses to treat a range of cancers, including breast, bowel, lung and skin diseases.

Prov Pandha said: “It’s almost like a universal agent - once it gets in it kills the cancer. It could be combined with lots of other treatments.”

He said the use of the virus could help “revolutionise” treatment for the disease.

The study, with Royal Surrey County Hospital, involved patients non-muscle invasive bladder cancer, which is found in the tissue of the inner surface of the bladder.


When tissue samples were examined after surgery, scientists could see that only the cancerous cells had been targeted - with other cells left intact.

The virus was found to have infected cancerous cells and replicated itself causing the cells to rupture and die.

And urine samples taken from patients after the treatment detected “shedding” from the virus - indicating that once virally infected cancer cells had died, the newly replicated virus continued to attack more cancerous cells.

“Reduction of tumour burden and increased cancer cell death was observed in all patients and removed all trace of the disease in one patient following just one week of treatment, showing its potential effectiveness. Notably, no significant side effects were observed in any patient,” the research found.

Scientists said the success of the trials was particularly significant because current treatments for the disease have limited success.

Transurethral resection, an invasive procedure that removes all visible lesions, has a high chance of disease recurrence, with rates ranging from 50 per cent to 70 per cent.

Dr Nicola Annels, Research Fellow at the University of Surrey, said: "Traditionally viruses have been associated with illness - however in the right situation they can improve our overall health and wellbeing by destroying cancerous cells.”

She said the use of the viruses “could transform the way we treat cancer and could signal a move away from more established treatments such as chemotherapy."

Dr Mark Linch, from Cancer Research UK, said: “Although at an early stage, these initial results are encouraging. It will be really interesting to see how this new virus-based therapy fares in larger trials in people with non-muscle invasive bladder cancer, particularly in combination with newer immunotherapies.”

This ties in well with old theories of fever curing cancer, see my post here

https://www.longecit...ow/#entry850113

Immunity over inability: The spontaneous regression of cancer
Thomas Jessy

https://www.ncbi.nlm...98/#!po=62.0000

Abstract
The spontaneous healing of cancer is a phenomenon that has been observed for hundreds and thousands of years and after having been the subject of many controversies, it is now accepted as an indisputable fact. A review of past reports demonstrates that regression is usually associated with acute infections, fever, and immunostimulation. It is stated that in 1891, William Coley of New York's Memorial Hospital developed the most effective single-agent anticancer therapy from nature, which faded into oblivion for various reasons. Cancer therapies have been standardized and have improved since Coley's day, but surprisingly modern cancer patients do not fare better than patients treated 50 or more years ago as concluded by researchers in 1999. This article peeks into the history of immunostimulation and the role of innate immunity in inducing a cure even in advanced stages of malignancy. The value of Coley's observation is that rather than surviving additional years with cancer, many of the patients who received his therapy lived the rest of their lives without cancer. In our relentless efforts to go beyond nature to fight cancer, we often overlook the facts nature provides to heal our maladies.


Its also possibly an explanation for C60 both curing and causing cancer, see here

https://www.longecit...ch/#entry849944

https://onlinelibrar.../mawe.201300082

Abstract: In vitro experiments have shown that C60 fullerenes exhibit cytotoxic effects against tumor cells and modulate the cytotoxic activity of immune cells. In vivo therapeutic experiments on the model of Lewis lung carcinoma showed that C60 fullerenes exhibit an antimetastatic effect (reduction of metastases by 27%), which is realized by activating macrophages and stimulating the synthesis of humoral factors, which significantly increase the cytotoxicity of treated animals serum.

What was interesting is that it worked by activating the macrophages - which we know from the Baati study were absolutely chock full of the stuff in the spleen. So it looks likely that C60 is anti cancer because it activates the innate immune system. Yet through its antioxidant action it actually suppresses the acquired immune system. In the study I linked to using a cancer vaccine with C60 fullerenes actually caused the cancer to spread more, yet both were effective individually.

I find this extremely interesting because old school cancer treatments, which were often able to completely cure even advanced cancer, involved infecting the patients so that they got a fever; see:

https://www.ncbi.nlm...98/#!po=62.0000


Edited by QuestforLife, 05 July 2019 - 07:21 AM.

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#2 Mind

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Posted 05 July 2019 - 05:44 PM

Interesting...."no side effects". Why didn't the patients "catch a cold"? It is not like the cold viruses could be contained once they are in the body.



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#3 QuestforLife

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Posted 05 July 2019 - 06:19 PM

Well they did infect the bladder cancer patients via catheter, so maybe it can't spread from there to the respiratory tract. Or maybe catching a cold is so minor if you have cancer, it's not counted as a side effect!

The really intriguing thing here is the return to a very old treatment for cancer, I.e. an infection.

Similarly we may see antibiotics replaced with viruses (phages) for defeating antibiotic resistant bacterial infections.

Old school is best, it appears!

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#4 Andey

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Posted 07 July 2019 - 04:03 PM

..

The really intriguing thing here is the return to a very old treatment for cancer, I.e. an infection.
 

 

  It aligns nicely with the observation that cancer patients often have a disturbed M1/M2 macrophage balance. Too much M1/low M2 or too low M1/high M2, and fixing that balance improves prognosis.

Infection will shift that ratio towards more M1 and will help one subset of patients.


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#5 AntoPax

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Posted 25 July 2019 - 01:03 PM

And Germany sponsoring faeces transplant?
Austrian researchers that create autoimmunity trough the immunocastration of the RANK/RANKL genes for Preventing breast cancer???
I wouldn't promote any tipe of nonsense for a long lasting and healthy life if I was in the people that made those studies.
Plus common cold in the CRISPR/gene therapy era it's not an illness to underestimate, by itself it killed 30 million of native Americans and we still didn't realize how it was possible in deep.
Why on longe there is no one talking of GC-MAF ? I olso tend to not sponsoring the government but when they are right it's a pleasure to do so.





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