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Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to

vitamin mineral

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#1 pamojja

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Posted 01 August 2019 - 09:32 AM


Surprising spin-off from the TACT trial, in that against the scientific method they didn't test one or two agents at a time, but high-dose multiples vitamins and minerals (6 tablets) against placebo. The results doesn't surprise me.

 

Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)

Intervention
Daily high-dose oral multivitamins and multiminerals (6 tablets, active or placebo).

Results
The primary end point occurred in 137 nonstatin participants (30%), of which 51 (23%) of 224 were in the active group and 86 (36%) of 236 were taking placebo (hazard ratio, 0.62; 95% confidence interval, 0.44-0.87; P = .006). Results in the key TACT secondary end point, a combination of cardiovascular mortality, stroke, or recurrent MI, was consistent in favoring the active vitamin group (hazard ratio, 0.46; 95% confidence interval, 0.28-0.75; P = .002). Multiple end point analyses were consistent with these results.

 
After 55 months there was a 9% absolute risk decrease in mortality compared to placebo!
 

 


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