https://www.nature.c...586-019-02638-w
Interesting study
Posted 07 September 2019 - 08:24 AM
Posted 07 September 2019 - 10:22 AM
"The diabetogenic effect of GH was also supported by the high prevalence of diabetes in acromegaly patients [1]. The effects of GH on systemic glycemic control is complex partly due to its indirect effects via insulin-like growth factor 1 (IGF-1), which has glucose-lowering effects similar to insulin. For instance, adults with GH deficiency are paradoxically associated with abdominal obesity and insulin resistance, which may be partly associated with their reduced IGF-1 action."
When giving exogenous GH to 'older' people, IGF-1 release is not as pronounced as in younger people. For this reason, a well known hormone clinic recommends IGF-1 to patients over 50 years of age.
Instead of (or additionally to) giving DHEA, maybe they should have given IGF-1.
Posted 07 September 2019 - 08:47 PM
Posted 11 September 2019 - 07:14 AM
Thanks for the link.Josh did a great analysis of this study.
https://joshmitteldo...something-else/
Posted 11 September 2019 - 12:08 PM
Thanks for the link.
Anyone trying the combination? It might be difficult to get Growth hormone.
Would something like MK677 achieve a similar effect?
Posted 11 September 2019 - 08:12 PM
Posted 15 September 2019 - 06:28 AM
In the past, I had read that DHEA was likely to increase estrogen in men and had some association with prostate cancer. Are these concerns with long-term low-dose DHEA?
Posted 15 September 2019 - 07:15 AM
In the past, I had read that DHEA was likely to increase estrogen in men and had some association with prostate cancer. Are these concerns with long-term low-dose DHEA?
If possible, have some blood tests done (include vitamin D as well). That way you can optimize the dosage. I have been on DHEA for years (25-40mg/day). My estrogen however turned out to be below reference range.
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