3 replies to this topic

[Ovidus]

Take a listen to this excellent interview with David Sinclair

https://peterattiamd...davidsinclair2/

 

At 1:09 he talks about senescent cells and the very first thing that he comments on with regards to senescence is the fat cells. He says that the fat cells in an older mouse or human are excessively senescent; well not unknown information perhaps, we have heard the increased inclination of fat cells to senesce before. 

 

My question is, can we get rid of these fat cells simply by losing bodyfat? When we lose fat, do we remove the senascent cells as easily as the non-senescent fat cells? Or are the senescent ones somehow more resistant to diet and exercise.

 

All in all, do you think you'd contribute to your longevity by being ultra lean, say 5% bodyfat while retaining normally functioning hormones and a good amount of muscle mass, like this guy https://www.cbass.com/

 

[zorba990]

What kind of fats are the mice eating?

[Kentavr]

It is necessary to reduce the amount of white fat, and brown fat must be preserved.

There are many immune cells in brown fat.

https://amp.kp.ru/da...6978.7/4039681/

(Interview in Russian, read using Google translator)

Edited by Kentavr, 20 September 2019 - 05:25 PM.

[Nate-2004]

I think just being not obese or overweight is good enough. Super lean probably won't buy you any extra healthspan as a human.