At the risk of sounding incredibly stupid, how exactly do scientists know that senolytic drugs have successfully killed senolytic cells in mice? In other words, can the death of senolytic cells be “seen” or apprehended in some way by various scientific measuring devises, or is their death assumed from the positive effects fisetin had on the mice’s physiology etc?
Also, how long after the mice taking fisetin did these positive effects manifest—one week, one month, one year after they took it? And in humans how long would these positive effects take to manifest after taking fisetin?