2 replies to this topic

[osris]

Here is an interview with senolytics skeptic Michael Fossel who says that senolytic therapy is dangerous:

 

https://www.leafscie...-for-longevity/

 

The interviewer seems to get the better of him though, and questions his many assumptions.

 

Here is a rebuttal of the interview and a critical discussion of it:

 

https://www.fightagi...nst-senolytics/

 

Your thoughts.

Edited by osris, 07 December 2019 - 02:38 PM.

[Rays]

Thanks for posting.

I think a three stage approach may be best:

1. Remove senescent cells
2. Increase stem cell pool
3. Lengthen telomeres

 

[HBRU]

Use of topoisomerase inhibitors for antineoplastic treatments may lead to secondary neoplasms because of DNA damaging properties of the compounds. Also plant derived polyphenols shows signs of carcinogenity, especially in fetuses and neonates who do not detoxify the compounds sufficiently.^[12][13][14] An association between high intake of tea (containing polyphenols) during pregnancy and elevated risk of childhood malignant central nervous system (CNS) tumours has been found.^[15][16]

 

^{https://en.wikipedia...erase_inhibitor}