Holy. ive been taking baclofen and it restored my gut health somehow......... it didnt work when I took it before but it does when im on lithium.... hm..
https://www.ncbi.nlm...pubmed/20201957 I found this ... In vitro, baclofen reduces chemotaxis of human peripheral blood mononuclear cells towards CCL2, CCL5, CXCL10, CXCL2 and CX3CL1.
My breathing has improved and so did my sleep. I think well I know due to my heavy stress inflammation was very severe. My gut barrier was ruined and my intestine was all over the place, baclofen reversed this... I could literally feel my organs going back in place to my abdomen, and I use NAC to heal the gut barrier. I think I have very bad bacteria there, I need to take some potent probiotic now that my intestine and everything is back in place. I also take tofisopam it has shown benefit for IBS but not sure how much its helping. But baclofen is very potent for anti inflammatory in the gut!. I also taken some Coconut oil capsules which made me sleepy I guess from killing bacteria, not sure when my intestines will be able to absorb anything again how long it will take. The reason lithium was absorbed is because of how bio available it is, and it has anti inflammatory effect, and that was enough for baclofen to work which is also goodly absorbed but not good enough that it would absorb without the lithium. I think due to the anti inflammatory of the lithium it healed my gut enough that baclofen worked. And we know the gut is very important it affects the whole body because it absorb nutrients. When I took NAC I had a warm feeling under my abdomen I assume it is my barrier healing itself or nac is fighting off bad bacteria. Like I said I need to restore my gut bacteria probably with probiotics... And have to look for some supplements for the gut like l glutamine or Butyrate .
Research suggests that stress hormones from the HPA axis, such as CRH, can increase intestinal permeability and cause inflammation [15, 16].
Research suggests that disturbances in the gut microbiota may cause gut barrier dysfunction in various disorders and diseases [37].
Some harmful bacteria may gain access to the body by altering tight junctions to increase gut permeability [38].
Molecular studies have shown that inflammation may increase intestinal permeability through TNF-alpha, IL-1beta, IFN-gamma, Nf-KB, and other cytokines [44, 45, 46, 47].
Prebiotics are fibers that stimulate the growth of beneficial bacteria in the gut.
Edited by farshad, 21 January 2020 - 12:41 AM.