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Application of Progesterone induces regenerative response?


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#1 lukas_93

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Posted 31 January 2020 - 11:32 PM

I came across this really interesting article and wanted to know what you think? 








Adult Xenopus laevis frogs are capable of induced increased regenerative response


Improved limb regeneration is driven by a wearable bioreactor containing progesterone


Improvements occur at molecular, anatomical, and behavioral (functional) levels


A 24-hr treatment is sufficient to trigger many months of regenerative growth


The induction of limb repair in adult vertebrates is a pressing, unsolved problem. Here, we characterize the effects of an integrated device that delivers drugs to severed hindlimbs of adult Xenopus laevis, which normally regenerate cartilaginous spikes after amputation. A wearable bioreactor containing a silk protein-based hydrogel that delivered progesterone to the wound site immediately after hindlimb amputation for only 24 hr induced the regeneration of paddle-like structures in adult frogs. Molecular markers, morphometric analysis, X-ray imaging, immunofluorescence, and behavioral assays were used to characterize the differences between the paddle-like structures of successful regenerates and hypomorphic spikes that grew in untreated animals. Our experiments establish a model for testing therapeutic cocktails in vertebrate hindlimb regeneration, identify pro-regenerative activities of progesterone-containing bioreactors, and provide proof of principle of brief use of integrated device-based delivery of small-molecule drugs as a viable strategy to induce and maintain a long-term regenerative response.



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#2 lukas_93

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Posted 14 February 2020 - 11:42 PM

Okay let s rephrase that a little more provocatively: 

Do you think the mechanism would be similar if applied to human tissue?

I do not expect bone regeneration, but maybe better wound healing because it modulates inflammatory responses. 

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