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magensium mega dose

magensium mega dose magnesium

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#1 ibtisam_midlet

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Posted 05 February 2020 - 09:15 AM


i started testing magnesium last week, after trying up to 1200mg i just deosn't feel anything.
after searching, i have find that she have 42 days half life, so taking 420mg/day will lead to 35.28g added to your body then she will stop accumulating anymore

so i took 3g every 1 hour... after taking 9g a i start feeling:
moderate warmth and emotion bland (good)
moderate mescal relaxant
mild anxiolytic effect
some antidepressant effect
amazing vivid dreams (in night sleep)

it was a nice addition to my psychology health, now i started upping more..

after i reached 29g i have started getting mild respiratory depression, and slow heart rate add to that muscle weakness
all the effect was mild, but learned that i have touched the upper limit fastly because:
29g/(42*2)= 345mg
meaning, what i take is like i have i took 345mg/day for months until she stop accumulating anymore

i still have this symptoms after 2 day of stopping magnesium. i think it will despair after some weeks, then after this loading dose i will continue with typical 420mg/day

be nice, be careful and take magnesium mega dose ^_^


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#2 xEva

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Posted 06 February 2020 - 10:27 PM

what form of magnesium you take?

 

And, if it's a lot and I assume you take it with water, don't you get laxative effect? (25g of Mg sulfate, colloquially known as Epsom Salt, will do that).



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#3 ibtisam_midlet

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Posted 07 February 2020 - 01:08 AM

what form of magnesium you take?

And, if it's a lot and I assume you take it with water, don't you get laxative effect? (25g of Mg sulfate, colloquially known as Epsom Salt, will do that).

I used ampoule every one have 1.5g liquid Magnesium pidolate, in empty stomach + water

#4 ibtisam_midlet

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Posted 07 February 2020 - 01:58 AM

don't you get laxative effect?


Yes I get laxative effect but not Diarrhea, really I have never get Diarrhea in my life , you can say I'm genetically immune to this.

#5 UdonNoodles

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Posted 23 April 2020 - 02:08 PM

What is mescal relaxant? Also the vivid dreams make sense I heard that magnesium can enhance visual processes abilities, I think I'm going to do this too! Thanks for the idea!



#6 ibtisam_midlet

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Posted 23 April 2020 - 03:07 PM

What is mescal relaxant? Also the vivid dreams make sense I heard that magnesium can enhance visual processes abilities, I think I'm going to do this too! Thanks for the idea!


I mean Muscle relaxer, sorry for my broken English

glad that you find this useful *-*
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#7 UdonNoodles

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Posted 23 April 2020 - 05:09 PM

I mean Muscle relaxer, sorry for my broken English

glad that you find this useful *-*

Oh haha, apparently mezcal is a type alcohol so you might've not been far off.


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#8 ibtisam_midlet

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Posted 24 April 2020 - 05:57 PM

Oh haha, apparently mezcal is a type alcohol so you might've not been far off.

Just don't try the magnesium aspartate form , becouse the aspartate in it is androgynous agonist to NMDA receptors which will block the magnesium antagonisting effect

#9 Thorsten3

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Posted 25 May 2020 - 07:21 PM

I use the magnesium bicarbonate mixture where you ‘do it at home’. Try that one out. It’s some potent stuff. You just need carbonated water and milk of magnesia (magnesium hydroxide).

For a litre (or, as you guys say, a ‘quart’), I think it yields about 1500mg of very absorbable magnesium. I say absorbable, because it feels like I get hit by a ton of bricks when I drink it (anasthetic). Anecdotally telling me that it’s very bioavailable for my own physiology anyway.

If you do it too much you’ll notice lesser effects, but I guess that’s because you’re becoming more repleted in the mineral.

I only do it a couple of times per week (outside of what magnesium I get from diet). It’s easy to make for anyone who wants to try it (YouTube/google searches).

Edited by Thorsten3, 25 May 2020 - 07:31 PM.


#10 ibtisam_midlet

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Posted 30 June 2020 - 11:02 PM

after near a month the good and bad effect toleranced so i upped to 1.5g/day but even that i wasn't able to restore the effect, so bad

im thinking to upper to 5g/day which is 600g magnesium pidolate added to my body but it littel expensive


Edited by ibtisam_midlet, 30 June 2020 - 11:04 PM.


#11 pamojja

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Posted 02 July 2020 - 08:57 AM

after near a month the good and bad effect toleranced so i upped to 1.5g/day but even that i wasn't able to restore the effect, so bad

im thinking to upper to 5g/day which is 600g magnesium pidolate added to my body but it littel expensive

 

So Mg-pidolate - which I actually never seen anywhere sold - contains 12% elemental magnesium? Why you don't try cheaper forms?

 

Personally used in average 1.7 g/d of elemental magnsium during the last 11 years, from all oral forms available to me (up to 2.4 g/d elemental at times). What finally really helped against a severe Mg-deficiency were almost monthly additional Mg-sulfate IVs. After the 6th painful muscle-cramps have gone.
 


Edited by pamojja, 02 July 2020 - 09:00 AM.

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#12 ibtisam_midlet

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Posted 02 July 2020 - 09:15 AM

Mg-pidolate have high bioavailability unlike other magnesium salts so it's the same

#13 pamojja

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Posted 02 July 2020 - 09:41 AM

Mg-pidolate have high bioavailability unlike other magnesium salts so it's the same

 

You mean: "So it's NOT the same"? On what you base your assumption that Mg-pidolate has higher bioavailabilty?

 

Personally tried all better bio-avialable Mg-forms available to me (malate, taurate, ascorbate, threonate, etc) for many years. Deficiency only increased. After finding in a post of niner here at longecity, that those bio-availabilty studies only tested short-term, and there are other long-term studies which didn't find substancial differences, I also tryed cheapest Mg-oxide. Thereby found in my case (we are very individual, and most couldn't tolerate the amounts of oral Mg I take) it really doesn't makes a difference. Only the same amount of oral elemental magnesium was, what alleviated very pain-ful muscle-cramps. In the end only Mg-sulfate IVs got rid of them.
 


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#14 pamojja

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Posted 02 July 2020 - 10:51 AM

After finding in a post of niner here at longecity,..

 

A link to that now 7 years old post: https://www.longecit...e-6#entry566410


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#15 gamesguru

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Posted 04 July 2020 - 03:26 AM

Don't believe the half-life means it takes that long to work, or that mega-doses are safe.  The proper way to supplement magnesium or calcium is this: add 100-150mg daily through supplements to your diet without adjusting anything else in the positive or negative direction. Then simply wait, results will be felt within days and sustained indefinitely. Recommended forms of magnesium include glycinate, malate, and threonate. Before bed is best for glycinate, whereas threonate can be taken in small doses throughout the day. Also do not fall into the quackery of mega-dosing, there is no proven benefit, and many of these magnesium powders have trace (1-5 ppm) heavy metals (lead, mercury, cadmium, arsenic) so mega-dosing them will likely lead to some subclinical heavy metal poisoning to no benefit.


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#16 pamojja

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Posted 04 July 2020 - 11:39 AM

Don't believe the half-life means it takes that long to work, or that mega-doses are safe.  .. Also do not fall into the quackery of mega-dosing, there is no proven benefit, and many of these magnesium powders have trace (1-5 ppm) heavy metals (lead, mercury, cadmium, arsenic) so mega-dosing them will likely lead to some subclinical heavy metal poisoning to no benefit.

 

Well to believe is one thing, to know from 11 years of experience in high doses of magnesium something completely other.

 

During the 11 years I did 8 hair-tissue-mineral analysis. Though this test with toxic metals stored away in tissues, isn't accurate, it still would spot ongoing exposures from concurent ingestion. Not a trace of metal poisoning found.

 

The benefit of correcting a tested and severe Mg-deficiency is of course beyond doubt. Beside the most obvious of having not to live with frequent cruciating muscle-cramp pains. Though the dose and route for correcting is indeed very individual.

 


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#17 gamesguru

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Posted 04 July 2020 - 12:45 PM

Well to believe is one thing, to know from 11 years of experience in high doses of magnesium something completely other.

 

During the 11 years I did 8 hair-tissue-mineral analysis. Though this test with toxic metals stored away in tissues, isn't accurate, it still would spot ongoing exposures from concurent ingestion. Not a trace of metal poisoning found.

 

The benefit of correcting a tested and severe Mg-deficiency is of course beyond doubt. Beside the most obvious of having not to live with frequent cruciating muscle-cramp pains. Though the dose and route for correcting is indeed very individual.

 

Tissue-hair analysis are not indicative of serum levels, which in turn are not indicative of extracellular or bone density levels of Magnesium.  Care must be taken in paying attention to the patient's response and side effects, lest ye focus on irrelevant metrics like ye olde hair follicle concentration.

 

My experience in 3 years of treating patients has been this: prescribe them 100-150mg of daily magnesium while changing nothing else, and results can be felt well within weeks.

 

The half-life in bones and accumulation time there may take time, but the boosts in extracellular levels in the brain, heart, and muscles can be felt immediately.  Extended high doses are completely unneeded, and only likely to cause side effects.

 

Adult human bodies contain approximately 24 grams of magnesium, with 67% located in the skeleton, 31% intracellularly (20% in skeletal muscle), and only 1-2% extracellularly. Of this amount, one half is ionized, and 25-30% is protein bound.

 

As a result, levels found on routine serum testing, which only reflects that magnesium found in the extracellular space, is not representative of true total body magnesium stores (Moe, 2008).Serum levels are typically 0.7–1.0 mmol/L or 1.8– 2.4 mEq/L. Serum magnesium levels may appear normal even in cases of underlying intracellular deficiency, and true hypomagnesemia is common, possibly due to decreased intake or absorption, increased loss via the urine or diarrhea, or genetic factors (Henrotte, 1982).


Edited by gamesguru, 04 July 2020 - 12:48 PM.

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#18 pamojja

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Posted 04 July 2020 - 01:42 PM

Tissue-hair analysis are not indicative of serum levels, which in turn are not indicative of extracellular or bone density levels of Magnesium.

 

You got it wrong around: hair-tissue will contain the average amounts of minerals in the blood-stream during the last 3 months, while it was growing. That's why only about 1 inch from the skin is tested. Not of any other tissues though. But of dietary intake during the last 3 month, which have no other way than the serum before passing on to deeper tissues.

 

The half-life in bones and accumulation time there may take time, but the boosts in extracellular levels in the brain, heart, and muscles can be felt immediately.  Extended high doses are completely unneeded, and only likely to cause side effects.

 

I never felt anything from magnesium, than at megadoses the ceasing of pain-full muscle-cramps. Nothing ever immediately.

 

Mg-sulfate IVs though, do have a nice calming effect, and do create inner warmth if given fast.

 

 


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#19 gamesguru

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Posted 04 July 2020 - 04:43 PM

You got it wrong around: hair-tissue will contain the average amounts of minerals in the blood-stream during the last 3 months, while it was growing. That's why only about 1 inch from the skin is tested. Not of any other tissues though. But of dietary intake during the last 3 month, which have no other way than the serum before passing on to deeper tissues.

 

I never felt anything from magnesium, than at megadoses the ceasing of pain-full muscle-cramps. Nothing ever immediately.

 

Yes you're right, the serum levels are increased immediately but the hair samples only an average over three months.  That's why to achieve quicker results on hair follicle, large harmful dose is needed acutely than a slow and steady boost.  This is more likely to result in hypermagnesia at the behest of unwise doctors.

 

The megadoses are likely explained by the form of magnesium.. oxide and sulfate are poorly absorbed so an incredible quantity is needed.  The proper way is to use a highly water soluble and bio-available form such as citrate, malate, glycinate, or threonate.  Best luck in your learnings

 

This finding was also confirmed by a recent study in which both urinary excretion and serum levels of magnesium were significantly higher after single-dose administration of these two supplements in a randomized cross-over study design [20].


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#20 StevesPetMacaque

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Posted 04 July 2020 - 05:26 PM

Magnesium is absorbed primarily by an active mechanism at typical intake levels. However, this mechanism quickly saturates, and passive diffusion is limited to a few percent absorption (7%, according to this study on MgAcetate). If I'm interpreting it right, you might absorb 65 mg of a 100 mg dose of elemental Mg, 100 mg of 1000 mg elemental, and ramping all the way up to 10,000 mg elemental would yield 700 mg absorbed (assuming you don't rapidly flush your bowels at this intake). This limit should be largely independent of the Mg salt used. Our intestines necessarily have fairly tight controls on electrolyte absorption - or else, for example, drinking 2 liters of coconut water could cause your heart  to stop.

With intestinal inflammation, I assume the active transport is impaired, which might explain the need some have for megadosing or even IVs.

I've personally found epsom salt soaks to be quite effective, using 1 kg of salt in a bath for 1 hr / day.

Regarding Mg pidolate, the pidolate ion (pyroglutamic acid) is apparently a PDE5 inhibitor, like Viagra, which could explain "warmth" by vasodilation.


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