This topic is locked- Review Article
- Published: 20 January 2020
NAD+ homeostasis in health and disease
Nature Metabolism volume 2, p
9–31(2020)
Abstract
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to a new wave of scientific interest in NAD+. NAD+ levels decline during ageing, and alterations in NAD+ homeostasis can be found in virtually all age-related diseases, including neurodegeneration, diabetes and cancer. In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research.
https://www.nature.c...2255-019-0161-5
full article: https://imgur.com/a/w0d6Xv2
Edit: This was already posted here https://www.longecit...th-and-disease/
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pages9–31(2020)
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Edited by Nigeria Custom Officer, 28 February 2020 - 08:49 PM.
