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Clinical trials of Fisetin in a person with autoimmune thyroiditis

fisetin autoimmune thyroiditis

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#1 Engadin

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Posted 15 March 2020 - 11:35 PM


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S O U R C E :   FutureCollector

 

 

 

 

 

 

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In recent years, clinical trials of drugs that affect extracellular and intracellular damage leading to ageing of the body have begun. You can find more info here [1].
 
For example, with age, senescent cells accumulate in our body. They cannot perform their functions normally, their abnormal metabolism is the cause of chronic inflammation, which plays an important role in ageing.
 
Relatively recently, senolitics, substances that selectively induce apoptosis (lead to programmed death) of senescent cells, have begun to be studied. Their studies have shown that when senescent cells are destroyed in old mice, they begin to look younger, and the function of their body improves.
 
 
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In these studies, senolytic drugs have restored exercise capacity and capacity to form new blood and immune precursor cells in ageing mice to near youthful norms, while preventing age-related lung hypofunction, fatty infiltration into the liver, weakening or failure of the heart, osteoporosis, and hair loss. These treatments have also prevented or treated mouse models of diseases of ageing like osteoarthritis, fibrotic lung disease, nonalcoholic fatty liver disease (NAFLD), atherosclerosis, cancer and the side-effects of conventional chemotherapy, as well as neurodegenerative diseases of ageing like Parkinson’s and Alzheimer’s [2]!
 
Since senescent cells also arise in the immune system, being one of the causes of autoimmune diseases, there is a hypothesis that the destruction of senescent cells will help in the prevention and treatment of many autoimmune diseases.
 
It is important that the mechanisms of cell senescence and the effects of their destruction by senolitics are similar in mice and humans. For example, it has been shown that the combination of dasatinib (a relatively aggressive chemotherapeutics) and quercetin (flavonoid) works in humans as well as in mice when it comes to destruction of senescent cells [3].
 
Some drugs that have established senolytic effects are available for purchase just now. However, they are usually used in much lower dosages than is required for the senolytic effect. Such substances include the readily available and cheap bioactive flavonoid fisetin.
 
Mice experiments show that fisetin is about as effective against senescent cells as the dasatinib + quercetin combination. The advantage of fisetin, which is a plant substance, is its safety compared to many other drugs that have shown a senolytic effect [4].
 
There are currently three clinical trials in humans. They are conducted in Mayo Clinic (USA), where a special treatment protocol was developed. Mayo Protocol consists in taking 20 mg / kg of fisetin orally for two days in a row, after which a person takes the second course after a month or two months [5].
 
 
 
 
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Also tagged with one or more of these keywords: fisetin, autoimmune thyroiditis

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