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What is the hydroxychloroquine regime?

hydroxychloroquine

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#1 Mr Serendipity

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Posted 11 April 2020 - 11:12 AM


I’ve got my hands on 60 tabs of 200mg hydroxychloroquine sulfate (don’t ask how).

 

I’ve taken 1 tablet with 2 zma at 12:30 (11th April). 

 

Anyone know the regime, I’ve heard 600mg a day, but I don’t know whether that’s all at once or spread.

 

Any help would me much appreciated.


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#2 Mr Serendipity

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Posted 11 April 2020 - 11:20 AM

Ok I’ve taken another 2 10 minutes later, so basically a 600mg single dose. I also took another 2 zma, so that should be 40mg zinc.

 

Going to eat some food now. 

 

I went for a large single dose because it says an initial dose of 400-600mg for Rheumatoid Arthritis here: https://www.rxlist.c...drug.htm#dosage

 

Going to eat some toast with butter now as it said to take with a meal.

 

I’m not going to take any of my supplements, just in case I accidentally flush some of the dosage out. I might take 1g of vitamin c, might.


Edited by Jesus is King, 11 April 2020 - 11:21 AM.


#3 Mr Serendipity

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Posted 11 April 2020 - 11:40 AM

https://www.rxlist.c...drug.htm#dosage

 

Each tablet contains 200 mg hydroxychloroquine sulfate (equivalent to 155 mg base). Bottles of 100 tablets (NDC 59212-562-10).

 

Do not exceed 600 mg or 6.5 mg/kg (5 mg/kg base) per day, whichever is lower, as the incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded.

 

 

————

 

I’m 110kg, lets go 100kg to be conservative.

 

6.5mg/kg = 650mg

5mg/kg (base) = 500mg

 

3 pills = 600mg or 465mg base (155mg x 3).

 

So I should be okay to take 3 pills a day. I think I’ll take 3 pills with 4 zma a day at 12:30 as a single dose and hope for the best.

 

Any other input would be appreciated. 

 

 


Edited by Jesus is King, 11 April 2020 - 11:42 AM.


#4 Mr Serendipity

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Posted 11 April 2020 - 12:15 PM

https://www.candi.nh...id-19-treatment

 

  • Adults can take a maximum of 4 doses (up to eight 500mg tablets in total) in 24 hours.
  • Always leave at least 4 hours between doses.

 

Interesting dosage from the NHS website. Saying you can take 4g in 24 hours. I won’t be doing that, as I want to avoid any side effects or damage, especially to my retinas. But interesting this is on the NHS website.



#5 xEva

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Posted 11 April 2020 - 03:23 PM

the French study: hydroxychloroquine 200mg twice a day for 10 days  (+azithromycin 500 mg first day, followed by 250 mg once a day next 4 days)

 

Zelenko: hydroxychloroquine, 200 mg twice a day, for 5 days. (+azithromycin, 500 mg once a day, five days and  zinc sulfate, 220 mg once a day for five days)

 

looks like 200 mg twice a day should suffice

 

How you feel?
 


Edited by xEva, 11 April 2020 - 03:25 PM.

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#6 Mr Serendipity

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Posted 11 April 2020 - 05:06 PM

Hey thanks for the info. I don’t have that other drug, but I’m pretty sure there were some studies or doctors who have used hydroxychloroquine alone.

 

I feel low energy, light headed, my appetite is low, feel cold easily, and have headaches. Also I just went for a walk and it was an effort. And today I’m getting mentally stressed easily, very sensitive.

 

I’m going to keep my dose at 600mg with 40mg zinc, but may lower it to 400mg. I’ll look for some more studies when I can be bothered, at the moment I feel like I did Tuesday 31st of March. I really don’t want to move anywhere at the moment.

 

My first symptoms arrived on the 29th March, so it’s been 14 days now since first getting symptoms. I’m hoping this hydroxychloroquine will kick its ass in the coming week.

 

I also gave my wife 200mg and 20mg zinc (2 x zma). She’s fairing better, but she’s had a better immune system than me. But she was very low energy yesterday.

 

Anyway I’ll keep everyone updated. There has been one development, a very slight sense of smell is back, only slight, i think my sense of smell has been slightly better the last 3 days than a complete absence like before, but it’s so slight.

 

Oh and the low appetite might be nausea, feeling it now after I had some juice, probably why I don’t want to eat.
 

Edit: I forgot to mention the coughs come back, but it’s like once in awhile, not continuous like it was the first 2 days.


Edited by Jesus is King, 11 April 2020 - 05:15 PM.

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#7 xEva

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Posted 11 April 2020 - 06:00 PM

I don’t have that other drug, but I’m pretty sure there were some studies or doctors who have used hydroxychloroquine alone.

 

yes, the larger arm the the French study used hydroxychloroquine alone, 200mg twice a day for 10 days.

 

Nausea is a commonly reported side effect after the initial dosing.

 

I understand that you're over 100kg, still, the half life of hydroxychloroquine is:

 

Pharmacokinetics: Following a single 200 mg oral dose of PLAQUENIL to healthy males, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours (22.4 days).

Plaquenil ® hydroxychloroquine sulfate tablets, USP. - FDA

https://www.accessda...s045s047lbl.pdf


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#8 Mr Serendipity

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Posted 11 April 2020 - 08:40 PM

Oh wow that’s a massive half life, I didn’t realize that.

 

I think I will cut down to 400mg from tomorrow, with 40mg zinc.

 

Ill probably still take it as a single dose at 12:30. 
 

Btw smell and taste are definitely coming back. I was starting to get my smell back ever so slightly, but it’s gotten better since this morning where I’m 100% sure I’m regaining it (but it’s not fully restored yet). So I’m hoping after a short while on this dose, maybe a week, I’ll be symptom free. Things are already looking better, whether this is the hydrochloriquin and zinc working, or because it’s already been 14 days I don’t know, but I’m not taking any chances and I’m going to keep using the combo until I’m symptom free.


Edited by Jesus is King, 11 April 2020 - 08:59 PM.


#9 zorba990

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Posted 11 April 2020 - 09:03 PM

Have you even tested positive for Covid?
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#10 Mr Serendipity

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Posted 11 April 2020 - 10:17 PM

No. But I’m 100% sure we have it. We work in an essential business here in the U.K., so while everyone was in lockdown/self isolation, me and my wife were interacting with many people daily. I was also hitting the gym beginning of March. And everyone has been off at least a week at one point in the last month where we work, due to a continuous cough. Me and wife both lost a complete sense of taste and smell, not partial, a complete loss. I’ve lost my sense of smell before when megadosing zinc & copper, but it returned. My wife has never lost her sense of smell or taste before, and I’ve never seen her so pale before either. Shes also never been off work sick since the last 4 years she’s been working there.

 

I don’t think you need a test if you get the worst symptoms like complete loss of sense of smell and taste, and then recurring coughs, headaches, going really pale, feeling cold, and low energy, it seems pretty evident. It’s mostly CNS for us though, and not respiratory (funnily enough we both smoke too). Also our temp seems to be in the normal range most of the time, though I did get up to 37.6c when testing early on.

 

I mean we could both just have the flu, assuming the flu can cause a complete loss of smell and taste. But with everything going on, I’m pretty sure it’s the corona.

 

 

 

 



#11 Mr Serendipity

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Posted 14 April 2020 - 11:33 AM

https://www.ncbi.nlm...les/PMC2893117/
 

Beta-thalassemia

 

Thalassemia minor is clinically asymptomatic but some subjects may have moderate anemia. Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta globin gene on chromosome 11, leading to reduced (beta+) or absent (beta0) synthesis of the beta chains of hemoglobin (Hb).

 

————————————

Posting just in case my beta thalassemia minor has anything to do with my recovery time from covid 19. There’s been some research (from China) which I’ve posted in other threads saying covid 19 attacks the beta chains causing less Hemoglobin. Beta thalassemia minor already less synthesis of these chains.

 

Last time I had a blood test (years ago) I was anemic, which is the case with beta thalassemia minor. It’s a shame I lost the card and what’s on it, it might have said whether I’m beta + or beta 0. I got the card when I had a blood test for something else when I was like 7 years old.



#12 Mr Serendipity

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Posted 15 April 2020 - 10:44 AM

Just a quick update. I had to stop this today. Last night I became more yellow and anemic looking, getting out of breath easily, and didn't feel with it.

 

So my 4 days on hydroxychloroquine went like this (all with 40mg zinc from ZMA):

 

Sat: 600mg all at once

Sun: 400mg all at once

Mon: 400mg split

Tue: 400mg split 

 

After Sunday I decided if I wanted to do this properly, I was going to have to split the dosage like the study. So I took 200mg doses many hours apart.

 

But last night gave me a bit of a scare so I've decided to stop taking it.

 

Apparently hydroxychloroquine can cause anemia:

 

 

 

Hydroxychloroquine typically is very well tolerated. ... Rarely, hydroxychloroquine can lead to anemia in some individuals. This can happen in individuals with a condition known as G6PD deficiency or porphyria.

 

I don't know whether I have either of those conditions, I only know I have beta thalassemia minor.

 

Regardless, if in the future hydroxychloroquine comes out as cure or whatever, I'd only take it now while under hospital supervision.

 

 

As for results. It's honestly a mixed bag. One thing I noticed was my energy levels became better. Also my smell slightly returned at times. But then I developed a tickly cough, and my smell would go again, and then obviously last night. So I can't really say how much it's helped me in recovery. I think it can help, because of my smell returning after dosing. But I don't know whether I'm a complex case due to by beta thalassemia minor, or I have underlying health conditions. But I'll try and ride this out again now, with or without supplements.

 

If my energy levels stay normal enough, I'll probably go back to work next Monday as they've been asking for me to come in, and the NHS website says you can go back as long as you don't have a temperature, so it doesn't matter that I still have other recurring symptoms. But low energy is the worst anyway, I couldn't work with low energy, every other symptom I get is more of a nuisance than debilitating in my opinion (cough, headaches, lack of smell and taste), so I don't mind going back to work if I have normal energy levels anyway, plus being at home is boring as hell.


Edited by Jesus is King, 15 April 2020 - 10:57 AM.


#13 Mr Serendipity

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Posted 15 April 2020 - 12:58 PM

Okay a few things:

 

1. My sense of smell has definitely partially returned. This was when I was putting my garlic pills in my pill boxes and could smell the garlic well. However other smells and tastes are still dulled.

 

2. After looking at my skin colour today after a hot bath, I think I was more jaundice than anemic.

 

3. I’ve decided to go full blitzkrieg on this virus and my health and so I will be taking supplements everyday from now on, I’ve already taken them today, this is my supplement regime for the next 2 weeks:

 

[] = Dosage of pill, not total dosage

 

Morning

 

2 x Vitamin C [1g] (Any brand is fine as long as it’s ascorbic acid)

2 x Vitamin E (Healthy Origins - E400)

2 x ZMA [Zinc 10mg, Vitamin B6 3.5mg, Magnesium 150mg] (Supplemented/Amazon)

1 x B-Complex (Higher Nature - B-Vital)

1 x Borage Oil [1g] (Supplemented) 

1 x Vitamin A [3,300 I.U.] + Vitamin D [400 I.U.] (Holland & Barrett)

1/2 x Vitamin D [5000 I.U.] (Natures Aid)

1 x Vitamin K2 [5mg MK4] (Carlson)

1 x Pycnogenol [30mg] (Natures Aid)

1 x Ginger [500mg = 4mg gingerols/shogaols] (Natures Aid)

1 x Garlic extract (Higher Nature)

1 x Turmeric/Curcumin extract (Nature’s Aid)

1 x NAC [500mg] (ProFrontal)

1/2 scoop Sulbutiamine [not sure] (eBay, seller gone)

[Drink] 2 x lumped tsps of cocoa with sugar (Cadburys Bournville)

 

Before Bed

 

1 small cap (or 1/2 a big cap) of Ionic Magnesium (Good State)


Edited by Jesus is King, 15 April 2020 - 12:59 PM.


#14 Mr Serendipity

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Posted 15 April 2020 - 01:09 PM

Just posting this in case it’s relevant to what happened to me last night. My beta thalassemia minor is inherited from my fathers side who is Asian Indian.

———————————
 

https://europepmc.or...le/med/16753851

 

Jaundice and alpha gene triplication in beta-thalassemia: association or causation?

 

Abstract 

There are few studies investigating alpha globin gene triplications in beta-thalassemia in Asian Indians and its effect on phenotype, which was the primary aim of this study. Gap-PCR was performed in order to detect common alpha thalassemia determinants (-alpha(3.7), -alpha(4.2) and alpha alpha alpha(anti 3.7) triplication). Alpha-triplication was detected in 15.4% (10/65) of patients with thalassemia intermedia, 8.8% (4/45) of those with thalassemia minor and in 2.7% (2/74) of healthy controls. The severity of jaundice was higher in thalassemia intermedia cases with alpha-triplication and two of the alpha-triplication cases had a marked increase in serum bilirubin following intercurrent illness. Thus, alpha globin gene triplication is important genetic determinant underlying thalassemia intermedia in North Indians. Patients with alpha-triplication may develop prominent jaundice with marked increase in serum bilirubin following antecedent aggravating factors.
 


#15 Mr Serendipity

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Posted 16 April 2020 - 12:25 PM

I’m on the mend. Energy levels are returning. A bit of aches and pains and no full return of smell and taste. But feeling better and more normal than I have been since the 29th March.

 

I've also dropped the high strength garlic extract from my stack, as it can cause anemia, and I’ve never felt great on it tbh.

 

Also I never got aches and pains until after I experienced that jaundice (or hypoxia/anemia) episode 2 days ago. So I think my body was slightly damaged due to lack of oxygen or something. Other than that my energy levels are coming back and I’m feeling much more normal and better again.


Edited by Jesus is King, 16 April 2020 - 12:26 PM.

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#16 Mr Serendipity

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Posted 20 April 2020 - 08:44 PM

This thing never seems to go fully away, now it’s a tickle in the throat and coughs, and my sense of smell has regressed to partial again, for example I can’t smell my lavender plant, I can still eat hot sauces easily, but I can slightly smell wrights soap after washing my hands with it (which is a pungent smelling soap).

 

As my energy levels have normalized and I’m not getting any aches or pains anymore, I’m just going to stick to my supplement regime until a cure is officially announced, I’m sure I can tick over until then. 

 

Wife is still getting bouts of paleness and low energy at times.

 

 

My daily regime stack:

 

[] = Dosage of pill, not total dosage

 

Morning

 

2 x Vitamin C [1g] (Any brand is fine as long as it’s ascorbic acid)

2 x Vitamin E (Healthy Origins - E400)

2 x ZMA [Zinc 10mg, Vitamin B6 3.5mg, Magnesium 150mg] (Supplemented/Amazon)

1 x Passiflora Complex [Passiflora, Lemon Balm & Avena Sativa: extract equivalent is 250mg of each dried plant] (Nature’s Aid)

1 x B-Complex (Higher Nature - B-Vital)

1 x Borage Oil [1g] (Supplemented) 

1 x Vitamin A [3,300 I.U.] + Vitamin D [400 I.U.] (Holland & Barrett)

1/2 x Vitamin D [5000 I.U.] (Natures Aid)

1 x Vitamin K2 [5mg MK4] (Carlson)

1 x Pycnogenol [30mg] (Natures Aid)

1 x Ginger [500mg = 4mg gingerols/shogaols] (Natures Aid)

1 x Turmeric/Curcumin extract (Nature’s Aid)

1 x NAC [500mg] (ProFrontal)

1/2 scoop Sulbutiamine [not sure] (eBay, seller gone)

 

Before Bed

 

1 small cap (or 1/2 a big cap) of Ionic Magnesium (Good State)


Edited by Jesus is King, 20 April 2020 - 08:54 PM.






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