I'm looking for a way to upregulate the production of diamine oxidase. I have some issues that my be attributable to excess histamine and want to experiment. I've worked with mast cell stablizers (PEA and quercetin mainly), but it seems to me that if you have genetic polymorphism that causes you to produces less endogenous DAO, mast cells stablizers may not suffice. Mast cells that are functioning normally will release histamine and if you have no DAO to mop that up you're going to have issues.
The only things I've seen that are purported to raise endogenous DAO production are certain fats and copper supplementation if you are low or borderline low. Copper is one of those supplements that it's very easy to over supplement and the consequences are not benign. I'm willing to supplement copper if I can either determine that my levels are low or there is a dose that is unlikely to raise my copper excessively. Anyone ever convince a doctor to test for copper? That said, if there's another way to increase DAO production I'd be very interested in that.
