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treatment of mice w/ NMN increased precancerous and cancerous lesions, and pro-inflammatory cytokines

nmn nad

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#1 Phoebus

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Posted 11 July 2020 - 02:22 PM


https://doi.org/10.1...2255-019-0047-6
 

Nacarelli et al. took advantage of a mouse model in which expression of oncogenic KRasG12D is restricted to the pancreas. These mice develop PanINs, which progress into PDAC under stress. Remarkably, the authors demonstrated that interventions that altered the NAD+/NADH ratio affected the SASP and disease progression: treatment of mice with NMN increased precancerous and cancerous lesions, and upregulated immune-cell infiltration as well as the expression of pro-inflammatory cytokines3 . In contrast, pharmacological NAMPT inhibition with FK866 suppressed the induction of pro-inflammatory cytokines and senescence markers in the pancreas without decreasing immune infiltration or the acinar area. These findings confirm that the pro-inflammatory SASP contributes to the progression of pancreatic cancer, and this effect is aggravated by increasing NAD+ levels with NMN treatment (Fig. 1).

 
 
The blame this on NAD+ levels, but in reality the only thing they can say is the NMN did this. We don't know if NMN raising NAD had anything to do with this or not. We can only say NMN itself raised inflammation levels and increased precancerous and cancerous lesions in mice.

Edited by Michael, 11 July 2020 - 05:42 PM.

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#2 Michael

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Posted 11 July 2020 - 05:49 PM

Phoebus, others: again, please do not post links to sites providing back doors through paywalls: you're putting Longecity at risk of paratrooping lawyers and takedown bombardment.



#3 MikeDC

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Posted 11 July 2020 - 06:48 PM

This study used model mice that develop senescent cells by design. It is garbage.
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#4 bosharpe

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Posted 11 July 2020 - 06:51 PM

Worrying...


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#5 Phoebus

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Posted 11 July 2020 - 07:56 PM

This study used model mice that develop senescent cells by design. It is garbage.

 

and yet FK866 suppressed the induction of pro-inflammatory cytokines and senescence markers 

 

why didn't NMN do that? There has been claims NMN is anti inflammatory, at least in this situation it certainly was not 


Edited by Phoebus, 11 July 2020 - 07:59 PM.


#6 able

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Posted 11 July 2020 - 09:59 PM

Looks like this was published Feb 2019.  Interesting, but nothing definitive.  Doesn't seem like it scared researchers or investors away when it came out last year.

 



#7 MikeDC

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Posted 12 July 2020 - 10:38 AM

and yet FK866 suppressed the induction of pro-inflammatory cytokines and senescence markers

why didn't NMN do that? There has been claims NMN is anti inflammatory, at least in this situation it certainly was not

Because the mice was generally modified. NR was shown to decrease IL-6 significantly in a human study. Two papers have shown increasing NAD+ reduces cancer growth. Similar in effectiveness as FDA approved drugs. It also increases drugs effectiveness by a few fold.

#8 Phoebus

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Posted 12 July 2020 - 12:13 PM

Because the mice was generally modified. NR was shown to decrease IL-6 significantly in a human study. Two papers have shown increasing NAD+ reduces cancer growth. Similar in effectiveness as FDA approved drugs. It also increases drugs effectiveness by a few fold.

 

 

which two papers show increasing nad reduces cancer growth? 



#9 MikeDC

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Posted 12 July 2020 - 04:12 PM

which two papers show increasing nad reduces cancer growth?

https://www.fiercebi...ht-glioblastoma
https://www.biorxiv.....03.21.001123v1

Edited by MikeDC, 12 July 2020 - 04:24 PM.

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