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How to live to 150: The 3 horizons of longevity tech with Sergey Young

sergey young longevity horizons

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#1 Engadin

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Posted 23 September 2020 - 08:16 AM


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S O U R C E :   The ChalkBoard Magazine

 

 

 

 

 

 

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SERGEY YOUNG plans to live to the age of 200. And he’s not the first. Wellness is buzzing with the kinds of bio-hacks and breakthroughs that have health researchers like Sergey and the likes of Bulletproof’s Dave Asprey planning on a longer lifespan than many of us ever dreamed.  
 
As a longevity investor, meaning he invests in the kind of technologies designed to extend the quality and quantity of our lives, Sergey is on the cutting edge of many fascinating and, frankly, mind-boggling medical technologies.
 
We asked Sergey to talk to us about the top tech in each of the three longevity “horizons”, which he breaks down below. His mission? To help one billion people extend their healthy lifespans by making longevity affordable and accessible. The Longevity Vision Fund is his personal passion project, built to fund and accelerate life extension breakthroughs and to make them affordable and accessible to all. Sergey is one of few investors in the category globally and some of his investments might surprise you …
 
 
 
 
The 3 Horizons of Longevity
 
The three horizons of longevity provide a ‘map’ of breakthrough longevity innovations that Sergey and team use as a model:
 
HORIZON 1 – technology already available that has the potential to expand our lifespans to 100 years.
 
HORIZON 2 – technology available over the next 5-10 years with the potential to expand our lifespans to 150 years.
 
HORIZON 3 – technology available over the next 10-20 years with the potential to expand our lifespans to 200 years.
 
 
 
 
 
HORIZON 1
 
 
AI-BASED EARLY DIAGNOSTICS AND DISEASE DETECTION
 
 Studies of autopsies suggest doctors misdiagnose fatal illnesses around 20% of the time, including diagnoses that were simply delayed.
 
 Artificial Intelligence is helping doctors make earlier and more accurate diagnoses. Early diagnostics are crucial, as they can mean recovery rates of over 90% from certain types of cancer.
 
 AI is also helping doctors to save time during diagnostics, which can enable more patients to be seen. For example, it takes just 4 seconds to analyze a patient’s heart function on a cardiac RI scan using AI, while a human doctor without AI requires 13 minutes on average.
 
 Freenome, a Longevity Vision Fund portfolio company, is working on early non-invasive diagnostics of colon cancer using blood tests. It has demonstrated 100% sensitivity (the ability to correctly classify an individual as ′diseased′) for colorectal cancer testing using its multiomics platform, whereas the current standard test (fecal immunochemical test) only achieved 67% sensitivity.
 
 Doctors using Google’s AI tool LYNA are better at detecting advanced breast cancer (99% accuracy) than human doctors alone (as low as 38% accuracy) – even when looking for
extremely small metastases human pathologists might miss.
 
 
 
WEARABLES
 
 About 60% of consumers agree that wearables put them in control of their health and lead to healthier lifestyles.
 
 Growing adoption of wearables at relatively accessible prices and advanced functions resulted in the development of a whole new area of preventive healthcare.
 
 AppleWatch can save lives by monitoring your heart health via an ECG or calling an ambulance if it registers a hard fall.
 
 FitBit can help manage stress by tracking your HRV (heart rate variability) and reminding you to take a break and walk around every hour.
 
 Amazon’s new health & wellness band HaloBand can help control your weight by measuring your body fat percentage using a 3D body scan, which is considered ‘a better indicator of health than weight or BMI alone’.
 
 
 
TELEMEDICINE
 
 Telemedicine allows caring for patients remotely via video conference tools. It is helping to bridge the gap between people and doctors across different geographies and income levels, and facilitates access to healthcare for people who are symptomatic or disabled.
 
 Coronavirus has accelerated the adoption of telemedicine by helping to reduce the spread of the virus and protect medical staff. Hospitals are quickly adopting telehealth to treat quarantined patients. At the onset of the pandemic, The White House even lifted Medicare telemedicine restrictions, allowing more providers to accept Medicare payments for virtual visits.
 
 Teladoc Health, now used by more than 40% of Fortune 500 employers, is becoming a crucial feature in corporate health & wellness programs at companies such as Accenture.
 
 Microsoft Teams enables telemedicine by providing secure collaboration solutions via chat, voice, and video between medical professionals in a single hub that supports key compliance requirements (in addition to remote appointments with patients).
 
 
 
PERSONALIZED SUPPLEMENTS
 
 Health supplements can now be customized according to your dietary needs, beliefs, and preferences with the help of companies offering 3D-printing technology, online subscriptions, and online quizzes to tailor the pills you take.
 
 Not only can the nutritional content of pills be personalized, but so can the time when each component is released. For example, people who skip breakfast as part of their intermittent fasting routine and go to bed early can design a capsule that delivers some caffeine and essential nutrients in the morning, and a blend of relaxing and sleep-promoting herbs in the early evening.
 
 Multiply Labs uses 3D-printing technology to personalize not only the nutritional content of the pills, but also the time when each component is released.
 
 The time-release factor is achieved by 3D-printing a capsule with separate compartments of varying thickness. For example, a compartment with a thin wall might release the product within 30 minutes, while another thicker compartment in the same capsule, but is capable of containing the supplement for at least two hours.
 
 Nourish3d is another 3D supplement-printing company, which provides customizable vegan, sugar-free, made-to-order “stacks” (that look and taste like fruit gummies) on a flexible subscription basis and with delivery to home and work addresses.
 
 Bioniq starts you off with a comprehensive blood assessment that not only assesses your nutritional requirements to build your personalized daily vitamin formula. Monthly blood tests allow to modify nutritional content of your pack to satisfy your body’s changing needs.

 

 

 

HORIZON 2
 
 
AI IN DRUG DISCOVERY
 
 The development of a new drug is estimated at $2.6B. A lot of that money is effectively wasted, as it is spent on the 9 out of 10 candidate therapies that fail somewhere between phase I trials and regulatory approval.
 
 Artificial intelligence is transforming drug discovery, making the search for new pharmaceuticals quicker, cheaper and more effective.
 
 Insilico Medicine, a Longevity Vision Fund portfolio company specializing in AI-based drug discovery, is capable of designing, synthesizing and identifying a new drug target in just 46 days – in comparison to 2-3 years typically required using big pharma’s standard approach without the support of this technology.
 
 Insilico Medicine also demonstrated its ability to identify thousands of new molecules targeting the key coronavirus protein in just 4 days, which could serve as potential medications.
 
 Schrodinger is another drug discovery company that is helping to advance COVID-19 drug discovery efforts. In has partnered with Google Cloud, which is giving Schrödinger access to its powerful computing capacity to accelerate discovery for its commercial partners and its internal pipeline.
 
 
GENE THERAPY AND EDITING
 
 Gene therapies alter an organism’s DNA by allowing therapeutic genetic material to be added, altered or removed. Given the abundance of diseases where improper functioning of genes plays an important role, gene therapy is a game changer and has already proved to be lifesaving.
 
 Novartis is one of the companies pioneering gene therapy space. Its Zolgensma is one of the first gene therapies to be approved and is the first and only gene therapy for children with spinal muscular atrophy. Zolgensma was approved in 2019 and is already helping to save lives.
 
 4DMT (another Longevity Vision Fund portfolio company) is a gene therapy company developing next-generation gene therapies, more safe and effective. It is using ‘directed evolution’ technology – a method, which mimics the process of natural selection towards a certain goal, without waiting for random variations to occur over thousands of generations.
 
 
CELL THERAPIES
 
 Cell therapy is a treatment where viable cells are injected or implanted into the patient’s body to achieve a therapeutic effect – for example, by transplanting immune cells capable of fighting cancer cells or grafting stem cells to regenerate diseased tissues.
 
 Approved therapies include Kymriah (by Novartis) and Yescarta (by Gilead), which help treat hematologic cancers in children.
 
 Sigilon Therapeutics (a Longevity Vision Fund portfolio company) develops an encapsulated cell therapy platform based on a new class of therapeutics.
 
 It can produce a wide range of proteins to treat serious chronic disorders in a durable, controllable, and safe way without generating immune rejection or fibrosis.
 
 
 
Horizon 3
 
 
REPLACEABLE BODY PARTS
 
 The need for human organs far outpaces their availability, with more than 20 people dying each day awaiting a transplant. There are over 110,000 people on waiting lists in the U.S alone.

 



#2 Rocket

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Posted 24 September 2020 - 02:33 AM

Early diagnosis of cancer is good and bad; its a double sided sword.
Many cancers come and go without ever being a blip on the radar as the body can effectively protect itself. Now then suppose technology is good enough to detect a rogue cancer cell and you start undergoing chemo or start having body part cut out in surgery when the rogue cancer cell would have been eliminated had it been left alone.... That's a very real problem. Some men have their prostates removed or worse yet go onto androgen deprivation therapy or even physical castration (either way goodbye to being a man) for prostate cancer they could have lived their entire life with.

Is the human brain even capable of operating for 150 or 2 years??? There is finite space to store memories and learned skills. What happened when space runs out? That's not a philosophy question, that's real world nuts and bolts of what you will face.

What happens when you you can no longer recall entire decades of life or you lose your skills to do simple math or forget how to make breakfast because memory space is being written over, to use a computer analog.

As humans have never lived to be 200 its unlikely the brain evolved the capability to store memories and skills for 200 years.

How many times have you already looked through a photo album and been totally unable to recall the images you are looking at??? That will only worsen with the very advanced years you are looking to live.

If to live to be 200 you have to lose all your memories before 60 years of age, what's the point? Are you even you anymore?


The are so many problems and so much hand waving. The loss of growth hormone is detrimental to the body and the immune system.... But if you go on hgh therapy, eventually parts of your body that youndidnt want to grow WILL grow... like your heart and your prostate will DEFINITELY grow into bph. The loss of growth hormone is another double sided sword as on one hand you do not want youthful levels forever for the reasons outlined, but losing it means frailty and loss of the immune system.

Edited by Rocket, 24 September 2020 - 02:45 AM.

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#3 bosharpe

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Posted 24 September 2020 - 01:08 PM

Excellent post @Rocket 

Most refreshing. This is the side of the longevity I rarely see discussed in depth. Our psychology & capacity: are we capable, is it desirable, what would be have to transform into? We won't know until we get there I guess but we know we have limits.


Edited by bosharpe, 24 September 2020 - 01:09 PM.


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#4 Rocket

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Posted 25 September 2020 - 01:32 AM

Any way you look at the issues of living past 150, your life is a game of whack-a-mole. You will. Have to go onto hormone therapy for useful levels of sex hormones, but the sex hormones like testosterone cause issues with blood production, prostate issues... Estrogen isn't innocent either and is implicated in cancers. Hgh will renew the immune system and fend off frailty but you will get a bigger heart and other organs. So every therapy you take causes detrimental side effects that have to be countered. Your teeth also gradually wear out despite all the cleaning in the world. I don't think humans are built out of the right stuff for a life of 200 years; our physiology doesn't support it. Even if in 100 years you could transplant your brain in a new body, your brain isn't built to retain memories indefinitely. Likely there will be mental health issues not yet imagined associated with prolonging life to those unnatural numbers. Seems like if we want to double our lifespan we will need to roughly double our brain volume to some kind of organism with a very large head.

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#5 bosharpe

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Posted 26 September 2020 - 04:05 PM

I don't disagree. However, I would just say that those are current road blocks. Those limitations might be addressed in future.







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