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C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice

c60 c60-evoo c60-oo fullerene buckminsterfullerene

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#1 Captain Obvious

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Posted 01 November 2020 - 09:12 AM


EDIT: Sorry, i did not notice this was already posted in an old thread. However, as it's an important study, I will leave it here as a separate thread. In the light of evidence I think we can all move along now and forget about this potentially harmful chemical that does not seem to extend life even in laboratory animals.

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C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice

Grohn K., Moyer B., et al.

Published: 29 October 2020

GeroScience (2020)

 

Abstract

 
C60 is a potent antioxidant that has been reported to substantially extend the lifespan of rodents when formulated in olive oil (C60-OO) or extra virgin olive oil (C60-EVOO). Despite there being no regulated form of C60-OO, people have begun obtaining it from online sources and dosing it to themselves or their pets, presumably with the assumption of safety and efficacy. In this study, we obtain C60-OO from a sample of online vendors, and find marked discrepancies in appearance, impurity profile, concentration, and activity relative to pristine C60-OO formulated in-house. We additionally find that pristine C60-OO causes no acute toxicity in a rodent model but does form toxic species that can cause significant morbidity and mortality in mice in under 2 weeks when exposed to light levels consistent with ambient light. Intraperitoneal injections of C60-OO did not affect the lifespan of CB6F1 female mice. Finally, we conduct a lifespan and health span study in males and females C57BL/6 J mice comparing oral treatment with pristine C60-EVOO and EVOO alone versus untreated controls. We failed to observe significant lifespan and health span benefits of C60-EVOO or EVOO supplementation compared to untreated controls, both starting the treatment in adult or old age. Our results call into question the biological benefit of C60-OO in aging.

 

https://link.springe...-X9_dCxDpmVqS8U


Edited by Captain Obvious, 01 November 2020 - 09:19 AM.

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#2 Mind

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Posted 02 November 2020 - 08:21 PM

Here is the link to the other discussion: https://www.longecit...earch-at-ichor/


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Click HERE to rent this advertising spot for C60 HEALTH to support Longecity (this will replace the google ad above).




Also tagged with one or more of these keywords: c60, c60-evoo, c60-oo, fullerene, buckminsterfullerene

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