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C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice

c60 c60-evoo c60-oo fullerene buckminsterfullerene

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#1 Captain Obvious

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Posted 01 November 2020 - 09:12 AM

EDIT: Sorry, i did not notice this was already posted in an old thread. However, as it's an important study, I will leave it here as a separate thread. In the light of evidence I think we can all move along now and forget about this potentially harmful chemical that does not seem to extend life even in laboratory animals.


C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice

Grohn K., Moyer B., et al.

Published: 29 October 2020

GeroScience (2020)



C60 is a potent antioxidant that has been reported to substantially extend the lifespan of rodents when formulated in olive oil (C60-OO) or extra virgin olive oil (C60-EVOO). Despite there being no regulated form of C60-OO, people have begun obtaining it from online sources and dosing it to themselves or their pets, presumably with the assumption of safety and efficacy. In this study, we obtain C60-OO from a sample of online vendors, and find marked discrepancies in appearance, impurity profile, concentration, and activity relative to pristine C60-OO formulated in-house. We additionally find that pristine C60-OO causes no acute toxicity in a rodent model but does form toxic species that can cause significant morbidity and mortality in mice in under 2 weeks when exposed to light levels consistent with ambient light. Intraperitoneal injections of C60-OO did not affect the lifespan of CB6F1 female mice. Finally, we conduct a lifespan and health span study in males and females C57BL/6 J mice comparing oral treatment with pristine C60-EVOO and EVOO alone versus untreated controls. We failed to observe significant lifespan and health span benefits of C60-EVOO or EVOO supplementation compared to untreated controls, both starting the treatment in adult or old age. Our results call into question the biological benefit of C60-OO in aging.



Edited by Captain Obvious, 01 November 2020 - 09:19 AM.

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#2 Mind

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Posted 02 November 2020 - 08:21 PM

Here is the link to the other discussion: https://www.longecit...earch-at-ichor/

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Click HERE to rent this advertising spot for C60 HEALTH to support Longecity (this will replace the google ad above).

Also tagged with one or more of these keywords: c60, c60-evoo, c60-oo, fullerene, buckminsterfullerene

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