1 reply to this topic

[Danniel]

My big questions are:

1. can one get similar results by employing only a breathing technique? I am experimenting with the Wim Hof method.

2. has anyone experience with HBOT, HBO2 and eventually, mixing with CR or CR mimetics?

 

 

 

Was reading this: https://www.popularm...ging-in-humans/

 

Which was presenting this: https://pubmed.ncbi....h.gov/33206062/

 

To save you a click:

Abstract

Introduction: Aging is characterized by the progressive loss of physiological capacity. At the cellular level, two key hallmarks of the aging process include telomere length (TL) shortening and cellular senescence. Repeated intermittent hyperoxic exposures, using certain hyperbaric oxygen therapy (HBOT) protocols, can induce regenerative effects which normally occur during hypoxia. The aim of the current study was to evaluate whether HBOT affects TL and senescent cell concentrations in a normal, non-pathological, aging adult population.

Methods: Thirty-five healthy independently living adults, aged 64 and older, were enrolled to receive 60 daily HBOT exposures. Whole blood samples were collected at baseline, at the 30^th and 60^th session, and 1-2 weeks following the last HBOT session. Peripheral blood mononuclear cells (PBMCs) telomeres length and senescence were assessed.

Results: Telomeres length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT. The most significant change was noticed in B cells which increased at the 30^th session, 60^th session and post HBOT by 25.68%±40.42 (p=0.007), 29.39%±23.39 (p=0.0001) and 37.63%±52.73 (p=0.007), respectively. There was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT (P<0.0001). T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59 (p=0.0004) post-HBOT. In conclusion, the study indicates that HBOT may induce significant senolytic effects including significantly increasing telomere length and clearance of senescent cells in the aging populations.

 

[manofsan]

So is it reasonable to say that Hyperbaric Oxygen Therapy is  hypercaloric and also hypertrophic? If we think of a net reaction between fuel+O2, then does increasing the O2 reagent then mean more energy yield, and more metabolic activity, leaning toward anabolic processes?

 

I'd read that HBOT not only improves telomere length, but also causes stem cells to multiply. To me, both of these things are associated with a pro-anabolic shift.

 

So I'd imagine that you don't want to take Senolytics, or Rapamycin, or Metformin, etc with HBOT, because they'd work at cross purposes with it.  Maybe you'd want to take that stuff a few hours before undergoing HBOT.

 

I'm thinking you want to take lots of anti-oxidants along with HBOT, as well as stuff like NAD/NR/NMN  because those would help the stem cells.

 

What do you all think?

 

PS: I don't know why you've posted this thread topic under Senolytics, since HBOT is probably the opposite of senolytic.

Edited by manofsan, 20 March 2021 - 04:53 PM.