10 replies to this topic

[sub7]

Simply reducing your androgen levels for a period seems to regenerate the thymus

 

https://www.ncbi.nlm...les/PMC3990998/

 

It is not clear for how long one has to do this, but 4 months is a figure that has been suggested in the paper above

"Clinical trials of SSA have shown that an LHRH-agonist in a small cohort of prostate cancer patients between 60 and 77 years enhances thymic function (75).A significant increase was observed in naïve CD4+ and CD8+ T cells and NK counts 4 months after treatment."

 

Here is another studyİ
This is a direct interventional study and paints a far more complex picture that is way harder to interpret

https://www.ncbi.nlm...les/PMC3990998/
Results
33 pts were evaluable after response to ADT. The median age, PSA and T were 62 years, 2.2 ng/ml and 361 ng/dl, respectively. Median time to T recovery after a single 3-month shot of the GnRH agonist was 7 months (mos), range: 3-15 mos. Six mos after ADT, only 2 pts had more than minimal changes in thymus size (thymic index >2) on CT, however significant changes in naïve T-cell populations were detected in 20 evaluable pts.

 

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Now, injecting oneself with goserelin (a drug used to very dramatically reduce sex steroids) is an exceedingly harsh treatment and will make you very miserable. Recovery of sex steroid levels will also take very long and how long you will require to get back to normal is hard to predict.

There may be a better method, however. (If you are a male) One can get on a Trenbolone cycle or do another kind of anabolic steroid cycle. During the cycle one's natural production of sex steroids will go down to almost zero (depending on dosage) and when you stop the cycle suddenly, you will be walking around with very low (or zero) natural testosterone production for a while. There you have it...

I suggested Trenbolone because I had earlier remarked that Trenbolone increases Oxytocin production in the body up to 50-fold.  So if you wanted to carry out two back to back experiments, with one involving high Oxytocin plus whatever and the next round involving very low sex steroids, this is two birds with one stone....

 

[Believer]

It is very easy to reduce male hormone production. 4 hormone receptors in the brain controls the testicular production of male hormones. Estrogen, androgen, progesterone and prolactin receptors.

Activation of only one is sufficient to almost reduce testosterone to zero. For example high dose estrogen or high dose synthetic progesterone based hormones.

Activation of 2 hormone receptors will produce total hormone blockage.

For this purpose, in transgender women, estrogen and cyproterone acetate (progestogen) is used, which achieves total castration.

 

By using extremely high dosages of estrogen (50mg estradiol enanthate weekly), as you can see in my thread, I achieved complete abolition of spermatogenesis.

 

However, in transgender women their immune function actually declines when their testosterone is lowered and this is one of the recognized side-effects of HRT in transgender women.

I too experienced a decline in immune function.

 

You can also use androgen receptor antagonists like bicalutamide.

https://en.wikipedia...rmone_modulator

https://en.wikipedia...ki/Antiandrogen

Edited by Believer, 18 January 2021 - 11:07 PM.

[sub7]

 

By using extremely high dosages of estrogen (50mg estradiol enanthate weekly), as you can see in my thread, I achieved complete abolition of spermatogenesis.

 

 

Valuable contributions; thanks a ton.

This may or may not work -more likely it will not work, because you have to block all sex steroids (estrogen and testosterone at least) for this to work.

 

Do you mind linking to any threads you may have on this? Why did you want to do this? Only reason I can think of is prostate cancer..... (birth control is surely not worth this IMO) 

[Believer]

https://www.longecit...ogen-estradiol/

[Daniel Cooper]

It is very easy to reduce male hormone production. 4 hormone receptors in the brain controls the testicular production of male hormones. Estrogen, androgen, progesterone and prolactin receptors.

Activation of only one is sufficient to almost reduce testosterone to zero. For example high dose estrogen or high dose synthetic progesterone based hormones.

Activation of 2 hormone receptors will produce total hormone blockage.

For this purpose, in transgender women, estrogen and cyproterone acetate (progestogen) is used, which achieves total castration.

 

By using extremely high dosages of estrogen (50mg estradiol enanthate weekly), as you can see in my thread, I achieved complete abolition of spermatogenesis.

 

However, in transgender women their immune function actually declines when their testosterone is lowered and this is one of the recognized side-effects of HRT in transgender women.

I too experienced a decline in immune function.

 

You can also use androgen receptor antagonists like bicalutamide.

https://en.wikipedia...rmone_modulator

https://en.wikipedia...ki/Antiandrogen

 

Are you still taking this high dose regimen of estrogen?  If so, are you seeing feminizing effects? 

[Believer]

Are you still taking this high dose regimen of estrogen?  If so, are you seeing feminizing effects? 

Stopped after 90 days. I did become temporarily feminized but besides breast lumps and mild enlargement of my upper lip there are no lasting effects. I am back on anabolic steroids (on and off)
 

[Daniel Cooper]

Stopped after 90 days. I did become temporarily feminized but besides breast lumps and mild enlargement of my upper lip there are no lasting effects. I am back on anabolic steroids (on and off)
 

 

Everyone gets to make their own choices, but man I would not put my body on the hormonal roller coaster that you obviously are. Switching from a high dose of estrogen to presumably some testosterone analog. 

 

You're what, 25 - 26? You're running the risk of permanently damaging your ability to make testosterone naturally unless you really know what you're doing.  AASs are not to be taken lightly. It's a tightrope to walk even if you know exactly what you're doing.

 

But I am curious, what temporary feminization did you experience? That was a massive dose of estrogen you were on.

[Believer]

Everyone gets to make their own choices, but man I would not put my body on the hormonal roller coaster that you obviously are. Switching from a high dose of estrogen to presumably some testosterone analog. 

 

You're what, 25 - 26? You're running the risk of permanently damaging your ability to make testosterone naturally unless you really know what you're doing.  AASs are not to be taken lightly. It's a tightrope to walk even if you know exactly what you're doing.

 

But I am curious, what temporary feminization did you experience? That was a massive dose of estrogen you were on.

No change in sexuality (no attraction to men), which surprised me as with transgender women I know they experienced "motherly urges" and a deeper attraction to men at the 3 month mark.
 

Temporary effects were described in the thread I linked. I became much more social, talkative, positive in my affect and mindset (testosterone does the opposite). Improved hearing, vision, sense of smell. Much greater mental clarity.

[Rocket]

Androgen deprivation leads to gynocomastia, brittle bones, fat accumulation, sarcopenia and heart issues.... If you want to restore your thymus get on 1 to 2 iu of hgh...... This is old news. Doesn't anyone remember the work of Dr Greg Fahy?

[sub7]

Androgen deprivation leads to gynocomastia, brittle bones, fat accumulation, sarcopenia and heart issues.... If you want to restore your thymus get on 1 to 2 iu of hgh...... This is old news. Doesn't anyone remember the work of Dr Greg Fahy?

 

1- Androgen deprivation for only a brief period is very unlikely to do the above

 

2- Fahy's methods are extremely unproven at this point. The sample size way way too small and the entire protocol itself -how he is using DHEA to reduce the impact of GH on blood glucose for example- is very questionable.

 

3- Read his paper. As unclear and vague as his methodology is (which calls into question its value in the first place) it is still obvious that the dose used was not 1-2 iu... it is at least twice as much

[Rocket]

It is very easy to reduce male hormone production. 4 hormone receptors in the brain controls the testicular production of male hormones. Estrogen, androgen, progesterone and prolactin receptors.
Activation of only one is sufficient to almost reduce testosterone to zero. For example high dose estrogen or high dose synthetic progesterone based hormones.
Activation of 2 hormone receptors will produce total hormone blockage.
For this purpose, in transgender women, estrogen and cyproterone acetate (progestogen) is used, which achieves total castration.

By using extremely high dosages of estrogen (50mg estradiol enanthate weekly), as you can see in my thread, I achieved complete abolition of spermatogenesis.

However, in transgender women their immune function actually declines when their testosterone is lowered and this is one of the recognized side-effects of HRT in transgender women.
I too experienced a decline in immune function.

You can also use androgen receptor antagonists like bicalutamide.
https://en.wikipedia...rmone_modulator
https://en.wikipedia...ki/Antiandrogen

Estrogen therapy in men is directly related to strokes. Bad idea.

Androgen deprivation is VERY BAD for your health. if you want to grow boobs and LOSE bone and become depressed then androgen deprivation is for that person. Go read the cancer threads treated by androgen deprivation....

The OP posted thread at the top mentions trenbolone... LOL.If you like coughing and like dangerous extremely high lipids and if you enjoy sweating 3 cups of sweat every night and waking freezing and soaking wet then trenbolone is for you.

There is a reason why young healthy individuals have healthy levels of testosterone...

If you truly want to improve thymus function then A) hgh + dhea, or B) ghrp + dhea

I cant believe there is a thread on longevity about how chemically castrating yourself improves health, but hey, to each your own...

Edited by Rocket, 23 January 2021 - 02:38 AM.