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Do women experience less anxiety than men?


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#1 kurdishfella

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Posted 29 March 2021 - 10:52 AM

Women have twice as much progesterone levels

A hormone called Allopregnanolone which is synthesized from progesterone is an potent agonist on GABA-A, and we know how important GABA is in anxiety and women have twice as much! Not only that there are many more anti-anxiety benefits from progesterone alone and some other derivatives. Women make over 20mg daily and men around 10mg.

Women have higher Cortisol

Why is this good for anxiety you say? Well cortisol cuts of ACTH & CRH release in a negative feedback loop, so these two can never get out of hand. Also a derivative from cortisol down the path, called THDOC, is an potent agonist on GABA-A also.

Women have fewer CRH receptors

CRH means corticotropin-releasing hormone, which is your body primary stress hormone, it is mainly produced in the PVN but also in the hippocampus, amygdala and PFC to name a few. Women having less of these means they have less binding/activity = less anxiety

Women have higher glutathione levels

Glutathione is your body main antioxidant, women have more of this than men, this is beneficial becuase it gets rid of toxins and inflammation which can cause anxiety and lots of other bad things.

Women have smaller Amygdala

Need I say more? Men also have bigger cortex (more thinking more anxiety) & hypothalamus which has a huge role in fear processing/social defeat.

Women have higher growth hormone

To repair and heal their body if damaged. It regulates immune system and Cholesterol levels.

Women have smaller brain stem

Brain stem regulates the central nervous system, and is pivotal in maintaining consciousness. Having smaller means you don't understand and can't grasp stress the same and your CNS is less activated. Smaller locus coeruleus. On average, the BSTc is twice as large in men as in women and contains twice the number of somatostatin neurons(BNST).



They do worry more than men (emotional) yes, but don´t feel the physical anxiety as much, the type of anxiety that causes health problems. also Females tend to have a greater basal capacity to exert inhibitory control over undesired or habitual behaviors and respond differently to modulatory environmental contextual factors relative to males. Which means they can react less to stress and which means less anxiety. And ''Study demonstrates sex differences in CRF receptor 1 and 2 mRNA changes within unique subnuclei of the dorsal raphe nucleus and the posterior ventral tegmental area'' https://www.ncbi.nlm...pubmed/26696011 . they have smaller hippocampus.  women release dopamine when they talk thus they have higher levels of it which is anti-anxiety. But they do have higher rate of depression and i think its because they are smarter.

  they have higher dopamine and dopamine / or its analogues are weak agonists on CB1 which has calming effects..
they also have higher antioxidants activity in their brain / CNS etc
Not to mention the social construct, women are ''protected'' so to say and men are challenging other men and women dont in the way men do which gives a relaxing safe feeling in women but men not.most mental problems and more so among women are self inflicted. they have better immune system because they have lower testosterone which means healthier thymus and the healthier you are the more protected from real anxiety and not fake.

Edited by kurdishfella, 29 March 2021 - 10:58 AM.

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