Hello everyone. Serial intermittent faster (16:8), prolonged faster (7 days fasts), and Caloric Restriction person here....... Have been doing this all for roughly 7 years.
Upon all of my reading, I have come to the conclusion that the data in humans for CR is promising which is great. However, it seems for those who do not like CR, IF of course, could be an option to try to reap some of the benefits for longevity.... well it seems 16:8 in mice is great, but that is because a 16:8 in mice is like a 102 hour fast for humans. So the data showing benefits for 16:8 in humans may only be because of the naturally lower intake of calories one human would eat during an 8 hour window.... What I am trying to see is the hormetic benefits for humans doing 16:8 is less due to the actual time that has been restricted (16 hours), and more because the human being is only, even eating as much as they want in an 8 hour window, eating a lower total number of calories than if they ate all day for every 24 hours....... This may mean that 16 hour fasts in humans are too short to produce hormetic effects, but long enough that the human, when eating in an 8 hour window, still eats a low amount of calories, and that 16:8 for humans is only helpful due to the lower amount of calories they eat, rather than actual hormetic shifts....
What does everyone think? The first few studies here seem promising, but you have to dig further in the later links to see the not so awesome results we were hoping for in ters of actual hormetic changes in humans in 16:8
https://www.ncbi.nlm...gov/pmc/arti...
https://www.ncbi.nlm...gov/pmc/arti...
https://pubmed.ncbi....ih.gov/31808...
https://www.cochrane...CD013496/VAS...
https://www.ncbi.nlm...gov/pmc/arti...
https://www.ncbi.nlm...gov/pmc/arti...
In conclusion, just like everyone here I will continue CR... but fear anything less than a 100 hour fast will not help hormetically in humans...... So I am guessing IF is possibly useless in humans and perhaps the only good move is prolonged fasting plus CR.