4 replies to this topic

[RubiksKid]

Is there any consensus regarding the efficacy of CR mimetics? I know there used to be a lot of hype surrounding resveratrol. Did it ever pan out? 

[rodentman]

CR mimetics are a really broad concept.  When discussing mTOR, AMPK and SIRTs, etc... these are all pathways that are potentially mimicking mechanisms that CR activates.

 

So metformin, for example is thought to mimic CR by activating AMPK (among other things)

resveratrol is thought to mimic CR by activating SIRT1.

Rapamycin ..... mTOR

etc etc

 

Which ones work?  the jury is still out, but there's some pretty good data on Rapamycin, NAD+ precursors, and metformin.

 

But my personal favorite CR mimetic is intermittent fasting. 

[RubiksKid]

Which ones work?  the jury is still out, but there's some pretty good data on Rapamycin, NAD+ precursors, and metformin.

 

But my personal favorite CR mimetic is intermittent fasting. 

 

I'm fairly maxed out in terms of supplement funds right now, but I'll do some research on the ones you listed. My finances will only improve in the future.

 

And intermittent fasting isn't really a viable option for me. I'm already underweight. I'm trying to gain weight. :(

[rodentman]

I'm fairly maxed out in terms of supplement funds right now, but I'll do some research on the ones you listed. My finances will only improve in the future.

 

And intermittent fasting isn't really a viable option for me. I'm already underweight. I'm trying to gain weight. :(

 

A lot of the mTOR, AMPK and SIRTs, etc activators don't seem to be a big help for younger people, not until you hit your 40s or 50s.  This includes both NMN and Rapamycin.   I'm assuming your on the younger side, so if that's the case, I would hold off on them.

[RubiksKid]

 

A lot of the mTOR, AMPK and SIRTs, etc activators don't seem to be a big help for younger people, not until you hit your 40s or 50s.  This includes both NMN and Rapamycin.   I'm assuming your on the younger side, so if that's the case, I would hold off on them.

 

 

Oh, I see! Thank you for letting me know! I appreciate it.