7 replies to this topic

[MikeDC]

People thought NR and NMN are better than NAM as NAD+ precursor. In reality NAM is more efficient than NR and NMN.
NR is degraded by BST1 in the small intestine. Some of the NAM is transported to liver and some are transported to large intestine and converted to NA. NAM increases liver NAD+ more than NR even on equal molar basis. https://www.nature.c...467-021-27080-3

[Harkijn]

Mike , thanks for  drawing our attention to this important research. I must say that as you did before you draw a conclusion that , at first sight, cannot be found in the report.

[Learner056]

Would any of you know the difference between taking Ribose alone vs taking both Ribose + Nicotinamide together

 

Its hard to measure each time:  I get too much energy by taking Ribose alone vs I get depleted of energy (when taking NMN - which should be the expected outcome).  I have not yet measured the combination, but other people verify this energy depletion with Ribose, Nicotinamide combination.   My point being, why Ribose alone gives energy? when the combination does not. 

[SearchHorizon]

Thanks for a great find! The researchers seem to have done a ton of work to obtain the results. It is funny, however, that the authors didn't point out that oral NAM >>> oral NR. 

 

I wonder how oral NAM compares with oral lipsomal NMN. Any thoughts on this? 

[MikeDC]

Part of oral NAM is converted to niacin path in the intestine. The liver can also convert small amount of NAM to NR. So oral NAM is better than liposome NAM

[Jesus Evola]

Would any of you know the difference between taking Ribose alone vs taking both Ribose + Nicotinamide together

 

Its hard to measure each time:  I get too much energy by taking Ribose alone vs I get depleted of energy (when taking NMN - which should be the expected outcome).  I have not yet measured the combination, but other people verify this energy depletion with Ribose, Nicotinamide combination.   My point being, why Ribose alone gives energy? when the combination does not. 

 

Can you detail the dosing structure of your use of all the materials?

[MikeDC]

Ribose contribute to ATP production so ribose increases energy. Too much NAM will consume ATP and Ribose.

[Jesus Evola]

Ribose contribute to ATP production so ribose increases energy. Too much NAM will consume ATP and Ribose.

 

Ribose enhances the dose response of NAM and produces an effect coined "D-Ribose-driven-NAM-recruitment".  D-ribose not only enhances NAD+ production, but it also produces a reducing equivalent that converts NAD+ further into NADH and NADPH.