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Help Me Obi-Wan: Zinc Ionophores

coronavirus

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#31 Dorian Grey

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Posted 08 December 2022 - 09:54 PM

Glad to hear you're back on an even keel & having pleasant side effects Mr S. 

 

Never knew different forms of zinc could produce such a range of results, but I'll be looking for these with my different zinc supps now.  

 

Best Wishes for Better Health, & Cheers!  


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#32 Mr Serendipity

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Posted 09 December 2022 - 01:39 AM

Glad to hear you're back on an even keel & having pleasant side effects Mr S. 

 

Never knew different forms of zinc could produce such a range of results, but I'll be looking for these with my different zinc supps now.  

 

Best Wishes for Better Health, & Cheers!  

 

Cheers, I'm hoping my OCD and hypomania continues to improve, too early to tell if it's a cure, but there's definitely been improvement calmness of mind.

 

I think I must have had scurvy of the brain or something, the zinc deficiency only made sense after I tried everything under the sun to try and heal this lesion behind my ear for a year, until I started experimenting with higher doses of vitamin c and zinc and dropped the NAC, and it finally started to heal. In fact this is probably the reason why when I got covid it kicked my ass for a month even though I was taking supplements i.e. my body didn't have much zinc to fight it off with because it was being chelated by the NAC.

 

Also the benefits I got today are probably from the Good State Ionic Zinc (the big bottle not the dropper one) rather than the Zinc Biglycinate. I ended up taking 200mg (4 capsules) of the Zinc Biglycinate a couple of hours ago to see if it would do anything for my hardness (apologies for being crass) like Zinc Picolinate would give me, but don't see any effects. I then checked another brand (Peak Supplements) for 50mg Zinc Biglycinate, and they advertise the 50mg elemental zinc is actually from 180mg of Zinc Bisglycinate, while properly stating the elemental zinc is 500% of the RDA. While the brand I bought (Healthy Origins), advertises only the 50mg of Zinc Biglycinate, which means I was getting much much less elemental zinc than I thought, even though they still falsely state it's 455% of the daily value. To add to the confusion, Now Foods says 30mg elemental zinc is from 150mg of Zinc Bisglycinate (20%), which would not equate to 50mg of Zinc from 180mg of Zinc Biglycinate (27.77%) that Peak Supplements advertises. But then I found Zinc Biglycinate powder being advertised with 20% or 28% Zinc in it, which answers the discrepancy.

 

https://nutraceutica...on-grade-20-zn/

https://vitaactives....te-powder-28-zn

 

Basically all I'm trying to say is, maybe Zinc Bisglycinate might have had more observable effects like I noticed with zinc picolinate, had I known the 50mg of the brand I was taking was really equivalent to 10mg (20%) or 14mg (28%) of elemental zinc, which is not considered a high dose.

 

Just something to keep in mind when looking into Zinc supplements and how brands advertise.

 

I'm sending mine back to amazon (as I bulk bought 6), and getting the other brand. Funnily enough it will save me a ton of money, as healthy origins was £16 a bottle for 120 capsules for less elemental zinc (10-14mg), while peak supplements is £20 for 360 capsules with more elemental zinc (50mg). I've already bought 4 different brands of zinc now within a week (picolinate, bisglycinate, ionic, and now a better bisglycinate), thank God for amazon making returns so easy, I'll still keep the ionic zinc though as it seems to work with a little bit of nausea.

 

PS. I can't tell these days whether this post is a result of my hypomania, or I'm just being detailed and informative. I guess it could be a mixture of hypomania with better clarity of thought perhaps.

 

 

 

 

14.jpg

 

71A1ixvSdnS._AC_SL1500_.jpg

Zinc120Right_1296x.png?v=1622774313


Edited by Mr Serendipity, 09 December 2022 - 01:44 AM.

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#33 Mr Serendipity

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Posted 11 December 2022 - 03:49 AM

https://pubmed.ncbi....h.gov/24619814/

 

The bioavailability of different zinc compounds used as human dietary supplements in rat prostate: a comparative study

 

Abstract

The normal human prostate accumulates the highest levels of zinc (Zn) of any soft tissue in the body. The pool of zinc available to the body is known to significantly decrease with age. It is suggested that dietary Zn supplementation protects against oxidative damage and reduces the risk of cancer. Zinc sulfate and zinc gluconate were the most frequently mentioned in per os administration in studies on Zn supplementation. The major aim of the study was to compare the bioavailability of different Zn compounds (sulfate, gluconate and citrate) in the prostate after their daily administration to male rats at three different doses (3.0; 15.0; and 50.0 mg Zn/kg b.w.) for 30 days. The results show that bioavailability in the prostate differs significantly between individual zinc preparations. A significantly elevated Zn concentration in the dorso-lateral lobe of the prostate, compared to controls, was found in the rats supplemented with two compounds only: zinc gluconate and zinc citrate. However, after administration of zinc gluconate, this effect occurred even at the lowest dose. The lowest zinc bioavailability in the prostate was found in the rats administered zinc sulfate: no significant Zn increase was seen in particular zones of the prostate. To sum up, the use of zinc gluconate is worth considering as a possible means of zinc supplementation in men.

 

 

 

 

Interesting study where zinc sulphate didn’t effect zinc in rats prostate, even though we know zinc sulphate is bioavailable.

 

I wonder if this is why zinc picolinate has a noticeable effect on penile hardness I’ve observed several times in years past, which I don’t notice on other zincs.

 

I’m getting major insomnia from zinc bisglycinate currently, which I can’t understand except maybe the doses are too high, or something to do with the glycine. This is why I’m looking up studies on other bioavailable zincs.

 

Zinc definitely has an effect on muscle hardness though. I haven’t worked out in years, but my biceps look defined again. I noted a similar effect on my traps years ago when I was using zinc picolinate. Also zinc bisglycinate is still working on my calmness of mind, I’m basically anxiety free at the moment. But I do have insomnia, allergies (which is odd, cause zinc usually helps here), and I’m getting diahorrea, the latter 2 I never noticed even with stupid doses of zinc picolinate.

 

So I think I’m gonna send the zinc bisglycinate back, get some zinc gluconate, and I need to experiment more with the ionic zinc, though if glyconate works well without side effects, I’d prefer my zinc in a pill vs a liquid.

 

I’m also vaguely recalling that I never had issues with ZMA either when I use to take it before bed, insomnia that is. So another option to look into. Then again it could be the 5g of vitamin c I took today, which I’ve noted has caused me insomnia in the past from even 2g, hence why it’s been in my stack 1g for a long time. Also I’m not taking my stack either currently, just experimenting with zinc and vitamin c, so there’s another factor in this.

 

I’m hoping I will find the perfect zinc. I’m going to get gluconate and Zma and test those out.


Edited by Mr Serendipity, 11 December 2022 - 04:15 AM.

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#34 Mr Serendipity

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Posted 11 December 2022 - 11:38 AM

I’ve decided to go back to zinc picolinate, since it worked so well for me except the insomnia (which I’m getting from bisglycinate anyway), and I think if I stick to the lowest dose (22mg/1 pill) rather than taking more, I might be fine. Also I’ve decided to go back down to 1g of vitamin c as that could be causing me my insomnia as well. I think my wounds will heal regardless of megadosing vitamin c as the main culprit was a zinc deficiency.


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#35 Mr Serendipity

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Posted 12 December 2022 - 01:58 PM

I will share my experience of zinc and immunity, it’s not what you’d expect.

 

Before I got COVID, I had a terrible immune system for years. I would regularly get ill and wouldn’t understand why. Back then I was also taking extra zinc in supplement form, whether it was zinc citrate with copper, or ZMA.

 

During my COVID month (March 2020), where I was taking zinc, vitamin c, NAC, etc… and then eventually hydroxychloroquine, kung flu was kicking my ass more than anyone else I knew who had it, even my wife, and I was the supplement guy. After that I thought the NAC (the culprit again), had exacerbated a selenium deficiency because it is a cofactor of NAC and I wasn’t taking any selenium.

 

After my COVID experience, I added selenium to my stack, and since I did that, my immune system has been pretty much rock solid coming up 3 years. The change was night and day. I went from a bad immune system for years, to one that felt like a great immune system.

 

What makes my experience interesting to me, was I was taking extra zinc previous to March 2020 and still had a bad immune system. Over a year I’ve developed a severe zinc deficiency (an inability to heal a wound on my ear for over a year), and while this deficiency manifested symptoms in several ways, a poor immune system wasn’t one of them, which has been pretty much rock solid regardless.

 

Obviously I’m not discounting zincs importance in immunity. All I’m saying is it’s interesting my immune system still felt rock solid on a severe zinc deficiency but with selenium supplementation, then when it was horrible before with zinc supplementation but without selenium supplementation.


Edited by Mr Serendipity, 12 December 2022 - 01:59 PM.

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#36 Mr Serendipity

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Posted 12 December 2022 - 07:38 PM

Cheers, I'm hoping my OCD and hypomania continues to improve, too early to tell if it's a cure, but there's definitely been improvement calmness of mind.

 

I think I must have had scurvy of the brain or something, the zinc deficiency only made sense after I tried everything under the sun to try and heal this lesion behind my ear for a year, until I started experimenting with higher doses of vitamin c and zinc and dropped the NAC, and it finally started to heal. In fact this is probably the reason why when I got covid it kicked my ass for a month even though I was taking supplements i.e. my body didn't have much zinc to fight it off with because it was being chelated by the NAC.

 

Also the benefits I got today are probably from the Good State Ionic Zinc (the big bottle not the dropper one) rather than the Zinc Biglycinate. I ended up taking 200mg (4 capsules) of the Zinc Biglycinate a couple of hours ago to see if it would do anything for my hardness (apologies for being crass) like Zinc Picolinate would give me, but don't see any effects. I then checked another brand (Peak Supplements) for 50mg Zinc Biglycinate, and they advertise the 50mg elemental zinc is actually from 180mg of Zinc Bisglycinate, while properly stating the elemental zinc is 500% of the RDA. While the brand I bought (Healthy Origins), advertises only the 50mg of Zinc Biglycinate, which means I was getting much much less elemental zinc than I thought, even though they still falsely state it's 455% of the daily value. To add to the confusion, Now Foods says 30mg elemental zinc is from 150mg of Zinc Bisglycinate (20%), which would not equate to 50mg of Zinc from 180mg of Zinc Biglycinate (27.77%) that Peak Supplements advertises. But then I found Zinc Biglycinate powder being advertised with 20% or 28% Zinc in it, which answers the discrepancy.

 

https://nutraceutica...on-grade-20-zn/

https://vitaactives....te-powder-28-zn

 

Basically all I'm trying to say is, maybe Zinc Bisglycinate might have had more observable effects like I noticed with zinc picolinate, had I known the 50mg of the brand I was taking was really equivalent to 10mg (20%) or 14mg (28%) of elemental zinc, which is not considered a high dose.

 

Just something to keep in mind when looking into Zinc supplements and how brands advertise.

 

I'm sending mine back to amazon (as I bulk bought 6), and getting the other brand. Funnily enough it will save me a ton of money, as healthy origins was £16 a bottle for 120 capsules for less elemental zinc (10-14mg), while peak supplements is £20 for 360 capsules with more elemental zinc (50mg). I've already bought 4 different brands of zinc now within a week (picolinate, bisglycinate, ionic, and now a better bisglycinate), thank God for amazon making returns so easy, I'll still keep the ionic zinc though as it seems to work with a little bit of nausea.

 

PS. I can't tell these days whether this post is a result of my hypomania, or I'm just being detailed and informative. I guess it could be a mixture of hypomania with better clarity of thought perhaps.

 

 

 

 

14.jpg

 

71A1ixvSdnS._AC_SL1500_.jpg

Zinc120Right_1296x.png?v=1622774313

 

 

Also people should ignore my post on dosages as it might be totally wrong. I read a couple of comments on Reddit that labelling laws require the amount of elemental zinc to be listed in the dose, so the dosage advertised is probably entirely accurate.



#37 Mr Serendipity

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Posted 09 January 2023 - 01:47 AM

(myo)-Inositol is very popular for OCD, and quite benign.  My gal takes it for sleep.  Doesn't make you drowsy, but clears your head of those "thought loops" that can drive you crazy and/or keep you awake. I expect adding an ionophore to zinc when recovering from deficiency would expedite the process, but I really don't know.  I would think daily dosing of a good zinc supplement would accomplish the same thing in just a week or so time.  

Quick update. I ended up buying 15mg zinc gluconate because I thought the higher doses (50mg zinc bisglycinate) were giving me terrible insomnia and sleep quality. But even when I didn’t take any supplements I still had insomnia/bad sleep quality. I’ve sort of suffered from insomnia or bad sleeping times all my life (going to bed late, waking up late), but usually my sleep quality once I’ve awakened, at least in recent years, has been fine. I’ve also quit smoking 17 days straight now, so I wonder if sleep quality issues can be anything to do with nicotine withdrawal. I’ve also been waking up with the worst stuffy nose. Who would have thought after quitting smoking I’d be feeling worse.

 

Anyway I was clearing out a load of old supplements into the trash, and I found a 365 bottle of inositol (1g). I added one pill to my stack to try it out, and I swear the last couple of days it’s made falling asleep easier and improved my ocd thoughts. I also found inositol powder that I never ended up using, but because I think if I’m doing well with 1g, I might just trash the power and not mess with higher dosages.

 

Anyway inositol is defo up there for me as interesting atm. IP6 I trashed though, I couldn’t deal with its chelation previously, and after my NAC chelation zinc deficiency issue, I’m off chelation for awhile.

 

Also for the first time in my life I’m losing my appetite to meat, and I’m sort of naturally becoming vegetarian. No idea why, might be a phase. But I’m finding meat a bit repulsive to eat. I feel like lots of weird things happening to me psychologically since I stopped taking NAC.


Edited by Mr Serendipity, 09 January 2023 - 01:51 AM.

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#38 Dorian Grey

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Posted 09 January 2023 - 06:43 AM

Hey Mr S, & so glad you're getting some relief from the inositol.  Insomnia is a wicked affliction.  I've also found dimming the lights way down about an hour before I want to go to bed helps stimulate melatonin secretion from pineal gland.  I also dim my computer screen down, & use the "night light" feature (shifts bright blue screen light towards red) & dark mode formatting changes white boarders to black), which helps a lot.  

 

Hope this helps.







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