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nmn and Wallerian degeneration

nmn

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#1 ironfistx

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Posted 09 January 2023 - 06:59 AM


I read something that NMN contributes to Wallerian degenration (basically damaging brain problems).

 

When I googled this I found ALL KINDS OF STUFF EITHER WAY; saying it causes it, and saying it protects against it.

 

Does anyone have more information on this?

 

If true, this is evidence to stop nmn and not take it again.


Edited by ironfistx, 09 January 2023 - 07:00 AM.


#2 ironfistx

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Posted 10 January 2023 - 02:12 AM

NMN promotes Wallerian degeneration.

https://www.research..._fig5_267043651

 

 

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

https://www.nature.c...cles/cdd2014164

 

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria

https://pubmed.ncbi....h.gov/26686637/

 

Some of these talk about "Axon degeneration"

"Axon degeneration is a major contributor to the pathology of several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, traumatic axonal injury, and chemotherapy-induced peripheral neuropathy 1, 2. Genetic studies support the notion that preserving axon integrity and function is a viable therapeutic strategy for many of these neurological disorders 1, 2. Understanding the mechanism of axon degeneration is, of course, crucial for this endeavor. In a recent issue of Current Biology, a study by Di Stefano et al. presents data supporting a new model for axon degeneration [3]."

 

 

Last paragraph in this one:

https://www.scienced...960982217302294

And this sentence:

Based on previous studies, the authors hypothesized that NMNd protects against Wallerian degeneration in vivo by decreasing NMN levels.

 

Look, I don't understand this one:

https://www.scienced...960982217302294

It sounds like they're saying they gave them NMN to decrease NMN levels (?) which protected them.

 

The site here says it's protecting (but it's nmn.com, so...)

https://www.nmn.com/...eration-neurons

 

 

The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila

https://elifescience.../articles/80245

 

Potent activation of SARM1 by NMN analogue VMN underlies vacor
neurotoxicity

https://www.biorxiv....4261v1.full.pdf



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