NMN promotes Wallerian degeneration.
https://www.research..._fig5_267043651
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
https://www.nature.c...cles/cdd2014164
Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria
https://pubmed.ncbi....h.gov/26686637/
Some of these talk about "Axon degeneration"
"Axon degeneration is a major contributor to the pathology of several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, traumatic axonal injury, and chemotherapy-induced peripheral neuropathy 1, 2. Genetic studies support the notion that preserving axon integrity and function is a viable therapeutic strategy for many of these neurological disorders 1, 2. Understanding the mechanism of axon degeneration is, of course, crucial for this endeavor. In a recent issue of Current Biology, a study by Di Stefano et al. presents data supporting a new model for axon degeneration [3]."
Last paragraph in this one:
https://www.scienced...960982217302294
And this sentence:
Based on previous studies, the authors hypothesized that NMNd protects against Wallerian degeneration in vivo by decreasing NMN levels.
Look, I don't understand this one:
https://www.scienced...960982217302294
It sounds like they're saying they gave them NMN to decrease NMN levels (?) which protected them.
The site here says it's protecting (but it's nmn.com, so...)
https://www.nmn.com/...eration-neurons
The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila
https://elifescience.../articles/80245
Potent activation of SARM1 by NMN analogue VMN underlies vacor
neurotoxicity
https://www.biorxiv....4261v1.full.pdf