Unless I missed it, this has not been discussed
https://newsramp.com...690aed4eec003a8
Any idea at all what the drug might be? No mention of what it is, what MOA it has and what the mode of administration is...
Posted 23 August 2024 - 11:17 AM
Unless I missed it, this has not been discussed
https://newsramp.com...690aed4eec003a8
Any idea at all what the drug might be? No mention of what it is, what MOA it has and what the mode of administration is...
Posted 04 September 2024 - 12:51 PM
I found this
https://www.pharmain...maceuticals-inc
and
https://www.sec.gov/...696/forms-1.htm
See https://www.google.c...r-1 ingredients
Edited by simon007, 04 September 2024 - 12:57 PM.
Posted 11 September 2024 - 08:39 PM
Thanks a ton
In the first link you provided, he first talks how Telomir-1 extends telomeres and then says this too
Telomir-1 reversibly binds to essential metals preventing the ionization of those metals due to the Fenton reaction and therefore limiting their biological effects. Age-related diseases such as osteoarthritis, senile dementia, macular degeneration, hemochromatosis, and muscle wasting are just some of the potential applications. Although metal reactivity is required for eukaryotic organisms to reach healthy maturity, continued elevated and unregulated metal-induced enzymatic activity contributes to oxidation and inflammation. It has long been recognized that enzymatic reactions also play a key role in the formation of cancerous mutations and the development of diseases like hemochromatosis. By limiting available metals, thus inhibiting metal-induced enzymatic activity, Telomir-1 may prove to be an effective platform for treating a variety of diseases.
So does this drug do 2 totally unrelated things -as in extend telomeres and bind to metals???
Posted 11 September 2024 - 08:42 PM
So do we know what the ingredient is?
BTW it says orally dosed...
Posted 13 September 2024 - 09:10 AM
Thanks a ton
In the first link you provided, he first talks how Telomir-1 extends telomeres and then says this too
Telomir-1 reversibly binds to essential metals preventing the ionization of those metals due to the Fenton reaction and therefore limiting their biological effects. Age-related diseases such as osteoarthritis, senile dementia, macular degeneration, hemochromatosis, and muscle wasting are just some of the potential applications. Although metal reactivity is required for eukaryotic organisms to reach healthy maturity, continued elevated and unregulated metal-induced enzymatic activity contributes to oxidation and inflammation. It has long been recognized that enzymatic reactions also play a key role in the formation of cancerous mutations and the development of diseases like hemochromatosis. By limiting available metals, thus inhibiting metal-induced enzymatic activity, Telomir-1 may prove to be an effective platform for treating a variety of diseases.
So does this drug do 2 totally unrelated things -as in extend telomeres and bind to metals???
Annoyingly, the article make certain claims about telomere lengthening and telomerase activity increases, but it is rather vague and no plots are given. If it increases telomerase activity, then what is this bench marked against, given they are examining telomerase negative cells?
Given the claimed mechanism of action, it appears whatever benefit this substance may have on cells, it is not via telomerase activation. The whole thing smells of BS (this is the first substance that increases telomerase, etc, etc.).
But it is worth keeping a watching brief on in case I am wrong...
Posted 30 September 2024 - 01:06 PM
The CEO reportedly died with no mention of cause. There are two reports about miraculous changes in old dogs, one with terminal cancer.
Any chance somebody could get us some?
Posted 01 October 2024 - 10:08 AM
I just don't get this company - google is absolutely full of new stories about it, but there is not one piece of data for us to find out more details, for example, what is the evidence for their claims that it turns on telomerase (in stem cells)?
I am not revising my view that this is BS, but I will maintain a watching brief...
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