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The Dawn of a New Era


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#1

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Posted 18 September 2006 - 06:29 AM


On rare occasions we come across a news item that is not controversial, damning or otherwise based on negative sensationalism. Today is one such day. The accouncement of the MitoSENS project and funding for SENS research and the Methuselah Foundation is inspiring news indeed and not just for Immortalists, Transhumanists and other fringe movements and sub-cultures but for all of humanity. I don't think I am overstating the case if I suggest that we are witnessing the dawn of a new era in how science may transcend the chains of traditional grant-based funding and enable individuals to take greater responsibility for theirs' and their loved one's future by participating in donor-based research funding. The time has arrived when a non-scientist or non-millionaire can participate in guiding the scientific progress of humanity by choosing what project to donate and subsequently participate in funding and founding.

In the case of SENS, with two of the strands now being investigated by benchwork rather than opinion, namely LysoSENS and now MitoSENS, the debates can cease whilst experimental work will reveal, in due course, the veracity of those hypotheses. More importantly, with two of the seven strands being actively researched it means that SENS need no longer be constrained by how it positions itself in respect to the opinion of the scientific or press community, enabling its constitutents to adopt new strategies or alter investigative approaches without fear of castigation. That means more science and less PR, and that is good news too.

#2 Mind

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Posted 18 September 2006 - 06:58 AM

I agree....great news all around! The amount of money donated to Mprize seems to be accelerating. Research directly targeted at reversing aging is moving forward. I get the feeling that it is not such a taboo subject anymore. In the past everyone wanted to just "cure disease". Now more efforts are aimed at doing both, curing disease AND reversing aging.

#3 eternaltraveler

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Posted 18 September 2006 - 07:09 AM

Now more efforts are aimed at doing both, curing disease AND reversing aging.


the same thing if you ask me :))

#4 Brainbox

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Posted 18 September 2006 - 07:29 AM

I hope this means that the paradigm shift towards (improving general quality of life => curing disease => reverse aging) within the biological research community is actually starting to take place. :)

#5 Mind

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Posted 18 September 2006 - 02:35 PM

I hope this means that the paradigm shift towards (improving general quality of life => curing disease => reverse aging) within the biological research community is actually starting to take place.


I think it is taking place. MitoSENS and LysoSENS are exciting research avenues and very challenging. Bright young minds are attracted to such challenges and are probably more open to the idea of reversing aging.

#6 Mind

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Posted 18 September 2006 - 06:10 PM

Any idea what the next SENS effort will be named (possibly related to WILT or other nuclear gene issues)?

#7 jaydfox

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Posted 19 September 2006 - 02:55 AM

Any idea what the next SENS effort will be named (possibly related to WILT or other nuclear gene issues)?

Well, we've got LysoSENS, MitoSENS... Why not TeloSENS, the initial research for WILT?

Or how about SeneSENS, to deal with cellular senescence? [lol]

#8 jaydfox

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Posted 19 September 2006 - 03:06 AM

I don't think I am overstating the case if I suggest that we are witnessing the dawn of a new era in how science may transcend the chains of traditional grant-based funding and enable individuals to take greater responsibility for theirs' and their loved one's future by participating in donor-based research funding. The time has arrived when a non-scientist or non-millionaire can participate in guiding the scientific progress of humanity by choosing what project to donate and subsequently participate in funding and founding.

What I really like about this latest announcement is that Thiel isn't some eccentric, out-of-touch millionaire who inherited his wealth. He made his fortune because he's intelligent, rational, calculating, visionary... He's no fool, and his support for SENS research speaks volumes of the legitimacy of the SENS approach, critics in the scientific community notwithstanding.

And Prometheus, you're right that this signals a new paradigm, where people can fund research that wouldn't ordinarily be funded by the establishment. If people could look objectively at trying to intervene in the aging process, this research would be heavily funded. But there is so much philosophical, social, and religious resistance (leading inevitably to political resistance), that the establishment is virtually incapable of funding this type of research at this time. That would be fine if this research were being pursued for knowledge's sake, for the sake of finding things out because it's fun. But lives are at stake, hundreds of millions of them.

I only hope that other people will see Thiel's vision, trust his calculation and rationality, and follow in his footsteps, by donating. We need $6 million in donations in order for Thiel to make good on his $3 million in matching funds.

#9 John Schloendorn

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Posted 19 September 2006 - 03:58 AM

Heh Jay, these are great names. I can't wait to see them printed all over the web.

#10 Mind

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Posted 19 September 2006 - 06:58 AM

SeneSENS...hmmm...interesting how it comes out sounding a lot like "senescence".

#11 Mark Hamalainen

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Posted 19 September 2006 - 05:25 PM

I agree with you too Prometheus, this definitely feels like a paradigm shift. And in a way that the previous big donation didn't, mainly, I think, because it was anonymous.

Well, we've got LysoSENS, MitoSENS... Why not TeloSENS, the initial research for WILT?

Or how about SeneSENS, to deal with cellular senescence?


Heh Jay, these are great names. I can't wait to see them printed all over the web.


Sounds like a good idea for a contest, or at least another poll!

hmm.. nucleoSENS for chromosomal mutation
stemSENS for cell depletion
I like seneSENS, as if Strategies for Engineered Negligible Senescence wasn't tongue twisting enough!
neuroSENS for neurodegenerative plaques/aggregates
crossSENS or linkSENS for crosslinks?

#12 JonesGuy

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Posted 19 September 2006 - 05:40 PM

That anonymous donor, I think, did have an effect. It did on me, anyway.

#13 MichaelAnissimov

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Posted 21 September 2006 - 05:23 PM

Well, we've got LysoSENS, MitoSENS... Why not TeloSENS, the initial research for WILT?

Or how about SeneSENS, to deal with cellular senescence? [lol]


You heard it here first, folks.

crossSENS or linkSENS for crosslinks?


I'm actually using a crosslink breaker on myself today... it's only experimental but I'm using it. About 100X more potential than nootropics or supplements. Anyone hazard to guess which chemical it is?

#14 John Schloendorn

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Posted 21 September 2006 - 05:45 PM

Anyone hazard to guess which chemical it is?

The one that breaks a crosslink which has never been shown to occur in you? Hey, are you blinding yourself to whether or not you take it?




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