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Homomatrix


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#1 maestro949

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Posted 26 March 2007 - 12:20 AM


Here's a company called Curidium that has developed a platform called Homomatrix which takes target research, clinical and gene expression data from microarrays and attempts to identify underlying disease mechanisms. While aging might be a bit too complex for it to digest, perhaps a modified version that targets tissue or organ specific aging would be feasible for comparing various age groups? They recently used the software to discover gene expression profiles in the blood of Schizophrenia And Bipolar Patients.

Product description from the company website...

Curidium has developed a research platform that combines and integrates target discovery research with clinical data, to determine the underlying disease mechanisms or "molecular signatures" of disease. Known as Homomatrix® , the technology has adopted principles of genetics, molecular pharmacology and epidemiology to analyse biological data from disease and control patients.

Schematic representation of the application of Homomatrix:
(IP: Intellectual Property to Curidium / ID: Identification)

Curidium applies Homomatrix® to either gene (mRNA) expression data or protein activity measurements derived from any gene, protein or pharmacologically tractable target. It is a systematic process, allowing a gene or protein to be analysed and characterised as contributing to a potential disease mechanism.

On a genome-wide scale (e.g. using gene-expression microarrays), Homomatrix® is applied to identify underlying disease mechanisms, including signalling pathways and potentially novel gene-gene associations. The combined findings, covering the whole or a large part of the human genome, segregate the patient population studied into subgroups, each with a distinct molecular signature. Although the method has strong bioinformatics and biostatistics components, its uniqueness stems from a collection of proprietary pattern recognition tools and specific sequences of mathematical algorithms and statistical methods used to analyse human biological data.

Complemented by extensive know-how developed within Curidium, Homomatrix® is operated and managed in house, in support of target discovery, diagnostic and clinical development for internal programmes and planned customised collaborations with corporate partners.



Link to Company Website

#2 maestro949

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Posted 26 March 2007 - 12:30 PM

Here's a company that provides gene expression services.

SIRS Lab - Gene Expression Service

It'll be interesting to watch the costs of these services. I suspect at some point the informatics analysis will be something we can find or develop software for.

Edited by maestro949, 28 September 2007 - 08:22 PM.





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