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Arthritis - Osteoarthritis


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#1 shpongled

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Posted 19 August 2003 - 01:09 AM


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Guggulipid (an extract from commiphora mukul) is a natural anti-inflammatory agent which is effective against osteoarthritis. Because a recent JAMA report found that guggul may slightly increase LDL cholesterol (in contrast to many earlier findings which indicated a reduction in LDL), it should not be used to lower cholesterol until more data is available. It should also not be used by anyone with a thyroid disorder without medical supervision.
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Altern Ther Health Med. 2003 May-Jun;9(3):74-9.


The effectiveness of Commiphora mukul for osteoarthritis of the knee: an outcomes study.

Singh BB, Mishra LC, Vinjamury SP, Aquilina N, Singh VJ, Shepard N.

Southern California University of Health Sciences, USA.

CONTEXT: Ayurveda, the traditional system of healthcare in India, has many remedies for Osteoarthritis (OA). One of the ingredients most commonly found in Ayurvedic arthritis formulas is guggul, an oleoresin of the herb Commiphora mukul (CM). The authors have conducted both preclinical and clinical investigations of guggul for reduction of pain, stiffness, and improved function, and to determine tolerability in older patients with a diagnosis of OA of the knee. METHODS: The study was conducted using an outcome, quasi-experimental, model. Thirty male and female participants meeting the inclusion/exclusion criteria, with a score of 2 or more on the Kellegran-Lawrence scale for at least 1 knee, were admitted in the study. CM was administered in capsule form (500 mg concentrated exact delivered TID) along with food. The WOMAC Total Score was used as a primary outcome measure. VAS scales, 6-minute walk-test, and WOMAC subscales were used as outcome measures. RESULTS: At the end of treatment, there was a significant difference in the scores of the primary and secondary outcome measures. On the primary measure, WOMAC total score, participants were significantly improved (P < 0.0001) after taking the supplement for 1 month and continued to improve at the 2-month marker and follow-up. Secondary measures of pain in the VAS format demonstrated participant improvement; however, mood state, and current pain were not significantly different (P < 0.05) than baseline until the 2 month assessment (P < 0.001). CONCLUSIONS: Overall data indicate significant improvement for participants during the trial in both scales and objective measures used for assessment purposes. There were no side effects reported during the trial. CM appears to be a relatively safe and effective supplement to reduce symptoms of OA.
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Myrrhanol A is the antiinflammatory agent in guggul, being more potent than hydrocortisone. Ideally, a guggul extract used for arthritis would contain only the acidic fraction (which would not contain the guggulsterones, responsible for effecting cholesterol levels) but I do not think such a product is commercially available.
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Bioorg Med Chem Lett. 2001 Apr 23;11(8):985-9.


New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice.

Kimura I, Yoshikawa M, Kobayashi S, Sugihara Y, Suzuki M, Oominami H, Murakami T, Matsuda H, Doiphode VV.

Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan. ikukokim@ms.toyama-mpu.ac.jp

Myrrhanol A, a new triterpene isolated from guggul (Balsamodendron or Commiphora mukul Hook.)-gum resin, displays a potent anti-inflammatory effect on exudative pouch fluid, angiogenesis, and granuloma weights in adjuvant-induced air-pouch granuloma of mice. Its effects were more marked than those of hydrocortisone and the 50% aqueous methanolic extract of the crude drug. Myrrhanol A is a plausible candidate for a potent anti-inflammatory agent.
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An early animal study
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Arzneimittelforschung. 1977 Jul;27(7):1455-7.


Comparison of the anti-inflammatory activity of Commiphora mukul (an indigenous drug) with those of phenylbutazone and ibuprofen in experimental arthritis induced by mycobacterial adjuvant.

Sharma JN, Sharma JN.

In the present investigation a method of induction of experimental arthritis in animals was modified to provide a better model replica of human arthritis. Inflammatory syndrome, resembling rheumatoid arthritis in man, was induced in the right hock joint of albino rabbits by intra-articular injection of the killed mycobacterial adjuvant in liquid paraffin. Development of this arthritic syndrome was studied from a period of five months with and without drugs. Anti-inflammatory agents such as phenylbutazone, ibuprofen and fraction "A" of gum-guggual from Commiphora mukkul were administered orally at a daily dose of 100, 100 and 500 mg/kg, respectively, for a period of five months. All three drugs decreased the thickness of the joint swelling during the course of drug treatment. These results indicate the beneficial role of phenylbutazone, ibuprofen and fraction "A" of gum-guggul in experimental arthritis.

#2 rgvandewalker

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Posted 01 January 2004 - 04:17 AM

www.lef.org has a quite comprehensive arthritis protocol; it includes chondroitin, glucosamine, nettle, MSM, and an ayurvedic herb whose name I've forgotten. Supposedly, nettle supresses one inflammatory pathway, the herb the other. MSM, gluscosamine and chondroitin accelerate joint healing.

Taking all of the above, (except the ayurvedic herb...), for the last two years, both my wife and I have become asymptomatic. We also take arginine and ornithine for a month or so every six months, to get some human growth hormone. Her plantar fascitis and sciatica also healed, which we did not expect, since they had become chronic.

The doctor told both of us "There is no cure. You'll have to get used to it." and prescribed NSAIDs. He seems to have been mistaken. Admittedly, we had mild cases.

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