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resveratrol sounds like the only supplement worth taking


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#1 wootwoot

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Posted 30 December 2007 - 09:29 PM


Resveratrol seems to have the most tangible results and even then I am not too sure what they are... Too many supplements seem to have little to no effect other than for a few people. Am I just missing the good supplements?

#2 missminni

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Posted 30 December 2007 - 10:06 PM

Resveratrol seems to have the most tangible results and even then I am not too sure what they are... Too many supplements seem to have little to no effect other than for a few people. Am I just missing the good supplements?


ITA
My dad says the same.
My friend who just started a couple weeks ago agrees.
At first, I stopped all other supplements entirely, but after about
a week, I started working them back in. I still want to cover those bases,
and I actually missed glucosamine.
Nothing has as fast or positive effect as Res.
Especially trans dermaly w/DMSO. I had a stiff neck this morning
and rubbed some on the back of my neck, and I don't know if it is
the Res or the DMSO, but my neck felt mentholated for a moment and then
the pain was gone.


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#3 HaloTeK

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Posted 30 December 2007 - 10:39 PM

VITAMIN D during winter also seems crucial!

Don't fall for puny RDAs - prudent to supplement at least 1000-2000iu unless you are willing to get a vitamin D level test

#4 rabagley

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Posted 31 December 2007 - 12:48 AM

VITAMIN D during winter also seems crucial!

Don't fall for puny RDAs - prudent to supplement at least 1000-2000iu unless you are willing to get a vitamin D level test

I concur. Vitamin D3 at levels of 2000IU-8000IU day (higher levels in winter) are extremely beneficial for heart health, stroke, cancer, depression (seasonal affective disorder), etc. All sorts of things all over your body. There are more than 200 receptors all over your body for the active Vitamin D hormone. The exact level you should supplement should be checked by a vitamin D blood test (the goal level for healthy people is >50 ng/ml of 25(OH)D -- 60-100 ng/ml is an excellent range to maintain).

Also, be careful of how you get it. First, you only want calciferol (D3). The Vitamin D2 added to milk is about 20% as effective as D3. Second, it has to be in a softgel. Powdered Vitamin D, like that usually found in multivitamin capsules and tablets goes right through without any absorption. Cod liver oil is advertised as being a natural source of Vitamin D, which it is. It's also very high in Vitamin A, and in order to get 4000IU's of Vitamin D3 daily, you would have to take enough cod liver oil to get toxic levels of Vitamin A within a few weeks.

Carlson's makes a 2000IU softgel that's quite affordable.

#5 maxwatt

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Posted 31 December 2007 - 03:09 AM

VITAMIN D during winter also seems crucial!

Don't fall for puny RDAs - prudent to supplement at least 1000-2000iu unless you are willing to get a vitamin D level test

I concur. Vitamin D3 at levels of 2000IU-8000IU day (higher levels in winter) are extremely beneficial for heart health, stroke, cancer, depression (seasonal affective disorder), etc. All sorts of things all over your body. There are more than 200 receptors all over your body for the active Vitamin D hormone. The exact level you should supplement should be checked by a vitamin D blood test (the goal level for healthy people is >50 ng/ml of 25(OH)D -- 60-100 ng/ml is an excellent range to maintain).

Also, be careful of how you get it. First, you only want calciferol (D3). The Vitamin D2 added to milk is about 20% as effective as D3. Second, it has to be in a softgel. Powdered Vitamin D, like that usually found in multivitamin capsules and tablets goes right through without any absorption. Cod liver oil is advertised as being a natural source of Vitamin D, which it is. It's also very high in Vitamin A, and in order to get 4000IU's of Vitamin D3 daily, you would have to take enough cod liver oil to get toxic levels of Vitamin A within a few weeks.

Carlson's makes a 2000IU softgel that's quite affordable.


I think that gamma-tocopheral rich vitamin E is worthwhile, but not the 400 mg capsules that seem to be standard. I think 200 mg is actually closer to the peak level of the inverted U-shaped dose-response curve. It's hard to get even the "recommended" 30 mg/day even with a relatively healthy diet.

Individual requirements can vary all over the board for some things. Frequently northern-European peoples need many times the RDA of certain B vitamins. Others may have adverse reactions to megadoses of these (I am one.)

I think bilberry or blueberry extract and curcumin are worthwhile, as are r-alpha lipoic acid (in the proper stabilized form) and possibly acetyl-l-carnitine for those over 30 or 40 years old. Omega-3 in the form of EPA/DHA is good in moderation, if one is not getting a dietary source. This is easy to do with some salmon, tuna, herring, other cold-water fish, or wild game, venison; not all easy to add. Too much of anything is not good. Too much EPA may be pro-cancer.

I'm sure this isn't exhaustive, and other things are certainly beneficial, but may not be necessary optimal health.

#6 rabagley

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Posted 31 December 2007 - 03:55 AM

Too much of anything is not good. Too much EPA may be pro-cancer.

Now that's an interesting statement. A quick google, pubmed, and imminst search turned up nothing to mention any increased risk of cancer for any known dose (even "eskimo" doses).

Any references?

#7 maxwatt

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Posted 31 December 2007 - 06:01 AM

Too much of anything is not good. Too much EPA may be pro-cancer.

Now that's an interesting statement. A quick google, pubmed, and imminst search turned up nothing to mention any increased risk of cancer for any known dose (even "eskimo" doses).

Any references?


The double bond is prone to oxidation, and some have inferred that too much in body tissues leads to oxidation of these membranes, with various adverse effects; susceptibility to viral invasion, toxic oxidation by-products, etc. One thing that is formally known of too high an EPA intake is increased bleeding time. A little is good, it prevents clotting and ischemic strokes. Too much is not so good; increased bleeding can lead to hemolytic stroke.

Cancer Causes Control. 2007 Dec;18(10):1107-21. Epub 2007 Aug 29. Links
A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden).Wallström P, Bjartell A, Gullberg B, Olsson H, Wirfält E.
Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malmo, Sweden. peter.wallstrom@med.lu.se

OBJECTIVE: To study the associations between intake of various types of fat and risk of prostate cancer (PCa) in a population-based cohort. METHODS: We have studied 10,564 initially cancer-free men of the Malmö Diet and Cancer cohort, aged 45-73 years. Diet was assessed by a modified diet history method. Cases and clinical characteristics were ascertained via national and regional registry data. RESULTS: During a mean follow-up of 11.0 years, 817 incidental PCa cases were diagnosed. Out of these, 281 were classified as advanced. There were 202 cases occurring before 65 years of age. After adjustment for age and energy intake, there was no association between intake of any types of fat and risk of PCa, or between fat intake and advanced PCa or PCa occurring in persons aged <65 years. However, we observed positive associations between intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and risk of PCa. After adjustment for multiple confounders, the latter associations were weakened, but the results were otherwise virtually unchanged. CONCLUSIONS: This large study, with high-validity dietary data, does not support an association between intake of total, saturated, or mono-unsaturated fat and PCa risk. The observed associations between EPA/DHA intakes and PCa are difficult to interpret.

PMID: 17726648

#8 rabagley

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Posted 31 December 2007 - 07:17 AM

A quick google, pubmed, and imminst search turned up nothing to mention any increased risk of cancer for any known dose (even "eskimo" doses).

Any references?


The double bond is prone to oxidation, and some have inferred that too much in body tissues leads to oxidation of these membranes, with various adverse effects; susceptibility to viral invasion, toxic oxidation by-products, etc. One thing that is formally known of too high an EPA intake is increased bleeding time. A little is good, it prevents clotting and ischemic strokes. Too much is not so good; increased bleeding can lead to hemolytic stroke.

Cancer Causes Control. 2007 Dec;18(10):1107-21. Epub 2007 Aug 29. Links
A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden).Wallström P, Bjartell A, Gullberg B, Olsson H, Wirfält E.
Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malmo, Sweden. peter.wallstrom@med.lu.se

Pretty interesting. I had heard about the risk of stroke from extremely high, or "eskimo" doses of EPA (that's actually where I got the word that I used in my original question). Also, I do fully support the idea that Omega-3 supplementation follows a hormetic dose curve (inverted-U curve) with increasing benefits to a point and then reduced benefits beyond that point. Based on the low-confidence language in the last few sentences of the abstract ("difficult to interpret"), I think I'll stay with my moderate dosage (2400mg EPA, 1500mg DHA daily) until they can work out more detail on that relationship.

Thanks for the informative response.

#9 ikaros

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Posted 31 December 2007 - 01:26 PM

It might sound worth taking, but there are a lot of BUTs.

BUT nr. 1 - There are conflicting studies with Dr. Sinclairs research on resveratrol and life-extension. If it's truly life-extending there shouldn't be mixed results.
BUT nr. 2 - Most studies done indeed shown ample positice effects on cellular level, but because they are all in vitro studies, they almost become meaningless as what are the real effects in vivo.
BUT nr. 3 - Resveratrol's metabolism is way too problematic, that in practice all evidence points to the fact that it doesn't stick around in the body long enough to do any good.
BUT nr. 4 - The French paradox could be explained by other polyphenolic compunds in red wine, not solely by resveratrol.
BUT nr. 5 - Never underestimate the power of placebo in resveratrol users raving reports.

#10 missminni

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Posted 31 December 2007 - 02:09 PM

It might sound worth taking, but there are a lot of BUTs.

BUT nr. 1 - There are conflicting studies with Dr. Sinclairs research on resveratrol and life-extension. If it's truly life-extending there shouldn't be mixed results.
BUT nr. 2 - Most studies done indeed shown ample positice effects on cellular level, but because they are all in vitro studies, they almost become meaningless as what are the real effects in vivo.
BUT nr. 3 - Resveratrol's metabolism is way too problematic, that in practice all evidence points to the fact that it doesn't stick around in the body long enough to do any good.
BUT nr. 4 - The French paradox could be explained by other polyphenolic compunds in red wine, not solely by resveratrol.
BUT nr. 5 - Never underestimate the power of placebo in resveratrol users raving reports.



I'm a great believer in the placebo effect, so I am not saying that it's not possible, however, my dad and my friends parents who
were both extremely cynical about using it have had noticeable improvement after taking it and continue to use it with continued
improvement. Maybe you have to have age related issues in order to feel the difference when you take it. I don't know, but everyone I
personally know who is taking it from ages 39 to 92 has had noticeable all over improvement in regards to pain and just feeling good.
Maybe if nothing is wrong with you, you don't feel the effect of it. ??


#11 david ellis

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Posted 31 December 2007 - 04:09 PM

Oxidation of Omega3's can occur in two places, outside the body, and inside the body. What has occurred here is not clear, but from my experience with fish oil I would not be surprised that the association is due to the fish oil being oxidized before it is consumed. Not from oxidation in the body. Stale fish oil is very common.

QUOTE (maxwatt @ 31-Dec 2007, 01:01 AM) *
CONCLUSIONS: This large study, with high-validity dietary data, does not support an association between intake of total, saturated, or mono-unsaturated fat and PCa risk. The observed associations between EPA/DHA intakes and PCa are difficult to interpret.

PMID: 17726648

Edited by david ellis, 31 December 2007 - 04:10 PM.


#12 maxwatt

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Posted 31 December 2007 - 04:23 PM

It might sound worth taking, but there are a lot of BUTs.

BUT nr. 1 - There are conflicting studies with Dr. Sinclairs research on resveratrol and life-extension. If it's truly life-extending there shouldn't be mixed results.
BUT nr. 2 - Most studies done indeed shown ample positice effects on cellular level, but because they are all in vitro studies, they almost become meaningless as what are the real effects in vivo.
BUT nr. 3 - Resveratrol's metabolism is way too problematic, that in practice all evidence points to the fact that it doesn't stick around in the body long enough to do any good.
BUT nr. 4 - The French paradox could be explained by other polyphenolic compunds in red wine, not solely by resveratrol.
BUT nr. 5 - Never underestimate the power of placebo in resveratrol users raving reports.


reBUT#1: Can you cite the references, PMID would help. I am aware of a study in round worms that did not replicate his results. I also know of a study that found caloric restriction was not life extending in wild-type genetic strain of mice. Some are still disputing that caloric restriction works either.
reBUT#2 Not meaningless per se but warranting further study
reBUT#3 resveratrol only has to be present long enough, in sufficient concentration to activate sirtuin genes. Once activated, the affect 053 deacetlase, nfKappa_B PPAR and a host of other genes and enzymatic expressions. Some research has shown a plausible delivery mechanism via blood lipo-proteins. In vitro human studies have shown a peak serum level within two hours of oral administration, and a secondary peak six hours later due to hepatic biliary recycling.
reBUT#4 The French paradox has little to do with life-extension, I think, and more to do with prevention of death from coronary events. It has been known since the 1950's that a modest alcohol intake from any source will have this effect, but our puritanical cultural could never admit this as a matter of public policy as a health recommendation. BTW, the French are getting fatter and drinking less wine, and the paradox is almost a thing of the past.
reBUT#5 Placebo typically results in generally mild positive effects for 32% + or - of those studied. The informal poll we had here on self-reported resveratrol effects showed around a 50% positive effect. This is more impressive, in that the resveratrol quality and dose were not standardized.

Whether resveratrol is significantly life extending remains an open question. I fear most of the population will find their knowledge will go through two stages: First, too soon be sure it works, and second, too late for it to do much good. It is certainly not a toxic or harmful substance in the usual meaning of the word. I see no harm in taking it. As missmini pointed out, the more age-related problems one has, the more likely one is to notice a benefit. I think the positive results reported for arthritis alone, not just by me but by many others, are far beyond something that can be attributed to a placebo effect, or to mere COX2 inhibition.

#13 DukeNukem

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Posted 31 December 2007 - 04:34 PM

>>> Resveratrol seems to have the most tangible results and even then I am not too sure what they are... Too many supplements seem to have little to no effect other than for a few people. Am I just missing the good supplements? <<<

First, if you eat really, really well, then you can definitely cut back on supplementation, especially many vitamins and minerals. However, just because RSV seems to be the MVP of supps, doesn't mean it covers all the bases, or provides all the benefits to be had from other supps. There are definitely other superstar supps, like these:

o cocoa
o pomegranate (punicalagins)
o lipoic acid
o green/white tea (epigallocatechin-3 gallate)
o melatonin (entirely underrated by most people)
o blueberry (pterostilbene specifically — still underrated)
o vitamin C (3-6g daily)
o IP-6 (severely underrated)
o vitamin D3
o (I consider several of the glycation blockers superstars, too.)

BTW, I was taking and touting resveratrol, cocoa and pomegranate back when all of these where mostly unknown and underrated in this forum. I expect some of the underrated ones above to finally get their due eventually.

#14 shuffleup

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Posted 31 December 2007 - 05:51 PM

>>> Resveratrol seems to have the most tangible results and even then I am not too sure what they are... Too many supplements seem to have little to no effect other than for a few people. Am I just missing the good supplements? <<<

First, if you eat really, really well, then you can definitely cut back on supplementation, especially many vitamins and minerals. However, just because RSV seems to be the MVP of supps, doesn't mean it covers all the bases, or provides all the benefits to be had from other supps. There are definitely other superstar supps, like these:

o cocoa
o pomegranate (punicalagins)
o lipoic acid
o green/white tea (epigallocatechin-3 gallate)
o melatonin (entirely underrated by most people)
o blueberry (pterostilbene specifically — still underrated)
o vitamin C (3-6g daily)
o IP-6 (severely underrated)
o vitamin D3
o (I consider several of the glycation blockers superstars, too.)

BTW, I was taking and touting resveratrol, cocoa and pomegranate back when all of these where mostly unknown and underrated in this forum. I expect some of the underrated ones above to finally get their due eventually.


About time for Duke's 2008 supplement list with links!

#15 DukeNukem

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Posted 31 December 2007 - 08:42 PM

What I might do instead is a top 10 exotic supps list. That might be fun.

#16 tintinet

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Posted 31 December 2007 - 09:18 PM

What I might do instead is a top 10 exotic supps list. That might be fun.


Let's see 'em!

#17 sablystone

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Posted 02 January 2008 - 01:57 AM

>>> Resveratrol seems to have the most tangible results and even then I am not too sure what they are... Too many supplements seem to have little to no effect other than for a few people. Am I just missing the good supplements? <<<

First, if you eat really, really well, then you can definitely cut back on supplementation, especially many vitamins and minerals. However, just because RSV seems to be the MVP of supps, doesn't mean it covers all the bases, or provides all the benefits to be had from other supps. There are definitely other superstar supps, like these:

o cocoa
o pomegranate (punicalagins)
o lipoic acid
o green/white tea (epigallocatechin-3 gallate)
o melatonin (entirely underrated by most people)
o blueberry (pterostilbene specifically — still underrated)
o vitamin C (3-6g daily)
o IP-6 (severely underrated)
o vitamin D3
o (I consider several of the glycation blockers superstars, too.)

BTW, I was taking and touting resveratrol, cocoa and pomegranate back when all of these where mostly unknown and underrated in this forum. I expect some of the underrated ones above to finally get their due eventually.


Duke, what kind of melatonin dosing do you recommend for a 45yo male? thanks.

Edited by sablystone, 02 January 2008 - 02:01 AM.


#18 krillin

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Posted 02 January 2008 - 03:02 AM

Duke, what kind of melatonin dosing do you recommend for a 45yo male? thanks.


If you are already sleeping well, I think that a 1 mg time release product would be a good place to start. Jarrow's is dirt-cheap. Individual variability is great, but I did find this recommendation from some people who consider themselves melatonin gurus. (Can anyone find more-detailed recommendations?)

http://www.nutrimed...._melatonin.html

Recommendations for melatonin supplementation vary from 1 mg. (age 40) to 5 mg. (over age 75) at bedtime, or the amount necessary for a good night's rest.



#19 sablystone

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Posted 02 January 2008 - 03:12 AM

Duke, what kind of melatonin dosing do you recommend for a 45yo male? thanks.


If you are already sleeping well, I think that a 1 mg time release product would be a good place to start. Jarrow's is dirt-cheap. Individual variability is great, but I did find this recommendation from some people who consider themselves melatonin gurus. (Can anyone find more-detailed recommendations?)

http://www.nutrimed...._melatonin.html

Recommendations for melatonin supplementation vary from 1 mg. (age 40) to 5 mg. (over age 75) at bedtime, or the amount necessary for a good night's rest.

Thanks!

#20 DukeNukem

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Posted 02 January 2008 - 03:21 AM

>>> Duke, what kind of melatonin dosing do you recommend for a 45yo male? thanks.

I'm 46.5, and I take LEF's 6mg (or maybe it's 7.5mg) time-released capsules. Seems like time-released is a good idea, to prolong the benefit. Whatever mg you choose, I'd go with a time-released version. 3mg is probably a good starting dosage.

#21 krillin

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Posted 02 January 2008 - 04:12 AM

Individual requirements can vary all over the board for some things. Frequently northern-European peoples need many times the RDA of certain B vitamins. Others may have adverse reactions to megadoses of these (I am one.)


Do you think it's a cholinergic effect? Cholinergic excess causes irritability, you reported anger from excessive B1 or B2, and the following papers show cholinergic effects from these vitamins. (Yeah, I admit the B2 paper is a bit of a stretch, but B1 is definitely implicated.)

I think Deprenyl tablet rage might be cholinergic too. Edward reported cholinergic symptoms like edema and jaw and neck tension accompanying his irritability.

Ann Neurol. 1993 Nov;34(5):724-6.
Evidence for a central cholinergic effect of high-dose thiamine.
Meador KJ, Nichols ME, Franke P, Durkin MW, Oberzan RL, Moore EE, Loring DW.
Department of Neurology, Medical College of Georgia, Augusta 30912-3280.

In vitro animal studies have suggested that thiamine is involved in the presynaptic release of acetylcholine. Total thiamine content in cholinergic nerve terminals is comparable with that of acetylcholine, and the phosphorylation state of thiamine changes with release of acetylcholine. Thiamine binds to nicotinic receptors and may exhibit anticholinesterase activity. Based on these observations, we investigated the effects of pharmacological doses of thiamine on the cognitive deficits induced by the anticholinergic scopolamine in healthy young adults using a randomized, double-blind, placebo-controlled, double-crossover design. Drug effects were assessed by P3 event-related potential, quantitated electroencephalography, and free recall memory. Conditions included (1) baseline, (2) thiamine 5 gm p.o. and scopolamine 0.007 mg/kg IM, and (3) lactose PO and scopolamine 0.007 mg/kg IM. Thiamine significantly reduced adverse effects of scopolamine on P3 latency, spectral components of electroencephalography, and memory recall. The results are consistent with a cholinomimetic effect of thiamine in the central nervous system. Additional studies are needed to delineate the basic mechanisms and possible therapeutic efficacy of thiamine at pharmacological dosages.

PMID: 8239567

Can J Physiol Pharmacol. 1997 May;75(5):423-30.
Decompensation of hepatic and cerebral acyl-CoA metabolism in BALB/cByJ mice by chronic riboflavin deficiency: restoration by acetyl-L-carnitine.
Rao KV, Qureshi IA.
Division of Medical Genetics, Hõpital Sainte-Justine, University of Montréal, QC, Canada.

BALB/cByJ mice have an autosomal recessive deficiency of short-chain acyl-CoA dehydrogenase (SCAD) and show elevated excretion of urinary butyrylglycine, ethylmalonate, and methylsuccinate, which resembles the SCAD deficiency disorder in children. These mice are clinically normal, perhaps because of an efficient acyl-CoA conjugation system. We attempted to decompensate the acyl-CoA metabolism in mutant mice by chronic treatment with a riboflavin-deficient diet for 3 weeks to potentiate the SCAD deficiency. We studied the urinary profiles of organic acids, acylglycines, hepatic and cerebral profiles of carnitines, and ammonia to assess the potentiation of this disorder. Cerebral activity of choline acetyltransferase (ChAT) was determined to study the effects of acyl-CoA accumulation on the cholinergic system. The results indicate that in riboflavin-deficient mutant mice, the excretion of ethylmalonate, methylsuccinate, butyrylglycine, and dicarboxylic acids was enhanced. Hepatic and cerebral free and esterified carnitines were reduced, indicating a potentiation of the secondary carnitine deficiency. Hepatic ammonia levels, but not cerebral ammonia or glutamine levels, were elevated, indicating a tendency towards secondary hyperammonemia. Brain choline acetyltransferase activity was significantly reduced in striatum, implying a reduced availability of cerebral acetyl-CoA or a decreased cerebral transport of choline: Most of these changes were partially or completely restored by a concomitant treatment with acetyl-L-carnitine (ALCAR). In summary, we conclude that BALB/cByJ mice with SCAD deficiency, but with a functional urea cycle, might have an adequate adaptive mechanism to adjust to an excessive acyl-CoA load without hyperammonemia at the cerebral level. However, any deficiency of vitamins or cofactors in the diet could disturb an adaptation to this disorder and produce an effect on the cholinergic system.

PMID: 9250376

#22 sablystone

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Posted 02 January 2008 - 01:22 PM

>>> Duke, what kind of melatonin dosing do you recommend for a 45yo male? thanks.

I'm 46.5, and I take LEF's 6mg (or maybe it's 7.5mg) time-released capsules. Seems like time-released is a good idea, to prolong the benefit. Whatever mg you choose, I'd go with a time-released version. 3mg is probably a good starting dosage.

Thanks Duke!

#23 maxwatt

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Posted 02 January 2008 - 01:36 PM

Individual requirements can vary all over the board for some things. Frequently northern-European peoples need many times the RDA of certain B vitamins. Others may have adverse reactions to megadoses of these (I am one.)


Do you think it's a cholinergic effect? Cholinergic excess causes irritability, you reported anger from excessive B1 or B2, and the following papers show cholinergic effects from these vitamins. (Yeah, I admit the B2 paper is a bit of a stretch, but B1 is definitely implicated.)

I think Deprenyl tablet rage might be cholinergic too. Edward reported cholinergic symptoms like edema and jaw and neck tension accompanying his irritability.


That's a credible explanation. I had similar effects with centrophenoxine; it was suggested this was due to an inadequacy of acetylcholine, and to remedy it by supplementing with choline. This did not help. There is still a question why others do not have such symptoms, and the nature of the metabolic differences.

This thread belongs with general supplements more than with resveratrol

#24 tintinet

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Posted 02 January 2008 - 04:24 PM

Individual requirements can vary all over the board for some things. Frequently northern-European peoples need many times the RDA of certain B vitamins. Others may have adverse reactions to megadoses of these (I am one.)


Do you think it's a cholinergic effect? Cholinergic excess causes irritability, you reported anger from excessive B1 or B2, and the following papers show cholinergic effects from these vitamins. (Yeah, I admit the B2 paper is a bit of a stretch, but B1 is definitely implicated.)

I think Deprenyl tablet rage might be cholinergic too. Edward reported cholinergic symptoms like edema and jaw and neck tension accompanying his irritability.


That's a credible explanation. I had similar effects with centrophenoxine; it was suggested this was due to an inadequacy of acetylcholine, and to remedy it by supplementing with choline. This did not help. There is still a question why others do not have such symptoms, and the nature of the metabolic differences.

This thread belongs with general supplements more than with resveratrol


I had notable jaw tension when taking Prevagen. I was also (and still am) taking centrophenoxine, but I've not experienced this symptom with centrophenoxine without Prevagen.

Edited by tintinet, 02 January 2008 - 04:25 PM.


#25 kottke

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Posted 03 January 2008 - 10:02 AM

reBUT#3 resveratrol only has to be present long enough, in sufficient concentration to activate sirtuin genes. Once activated, the affect 053 deacetlase, nfKappa_B PPAR and a host of other genes and enzymatic expressions. Some research has shown a plausible delivery mechanism via blood lipo-proteins. In vitro human studies have shown a peak serum level within two hours of oral administration, and a secondary peak six hours later due to hepatic biliary recycling.


This may be a resounding question but: how much resveratrol do i need to take to turn on my sirtuin genes? Is my 100mg (Tru-Res) Country Life pill doing anything for me?

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#26 missminni

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Posted 03 January 2008 - 02:35 PM

reBUT#3 resveratrol only has to be present long enough, in sufficient concentration to activate sirtuin genes. Once activated, the affect 053 deacetlase, nfKappa_B PPAR and a host of other genes and enzymatic expressions. Some research has shown a plausible delivery mechanism via blood lipo-proteins. In vitro human studies have shown a peak serum level within two hours of oral administration, and a secondary peak six hours later due to hepatic biliary recycling.


This may be a resounding question but: how much resveratrol do i need to take to turn on my sirtuin genes? Is my 100mg (Tru-Res) Country Life pill doing anything for me?

I don't know how much you have to take to activate the situin genes, but I was taking Jarrows 100 for almost a year (100 mg t res out of a 500 mg capsule) and felt absolutely nothing.
Not until I started using the 98% pure powder did I notice any results. You can't really up your dosage with what you are taking without having an uncomfortable laxative effect. I can't say that when I was taking the Jarrows 100 if it was doing anything or not...but i certainly didn't notice
anything. The first day I took 400 mg of 98% pure resveratrol, I noticed.





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