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Sirtris Diabetes Study


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#1 Anthony_Loera

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Posted 07 January 2008 - 09:52 PM


I got this from a Scottrade email:

Cheers!
A

CAMBRIDGE, Mass., Jan 07, 2008 (BUSINESS WIRE) -- Sirtris Pharmaceuticals, Inc.
(NASDAQ: SIRT), a biopharmaceutical company focused on discovering and
developing small molecule drugs to treat diseases of aging such as Type 2
Diabetes, announced today that the Company's first product to enter the clinic,
SRT501, was found to be safe and well-tolerated, and was found to significantly
lower glucose in an oral glucose tolerance test conducted as part of a 28 day
Phase 1b clinical study in patients with Type 2 Diabetes. These data were
presented at the 26th Annual JPMorgan Healthcare Conference on Monday, January
7th 2008 at 1:30 pm PST in San Francisco.

This 28-day Phase 1b study was designed to assess the safety, tolerability and
pharmacokinetics of once-daily, orally administered doses of either 2.5 g or 5 g
of SRT501 in patients with Type 2 Diabetes who were naive to other diabetes drug
treatments. Both doses of SRT501 were found to be safe and well-tolerated, and
pharmacokinetics, a measure of drug levels in the blood, were identical at days
one and 28, suggesting no drug accumulation. There were no serious adverse
events and no dose-related adverse events. Importantly, SRT501 showed a
statistically significant improvement in an oral glucose tolerance test on day
28 at two hours and a trend towards lower fasting plasma glucose levels.

SRT501 is also being tested in patients with Type 2 Diabetes in a Phase 1b BID
(twice daily administration) study and in a Phase 2a study in combination with
metformin, the current first-line therapy for Type 2 Diabetes. SIRT1 is the
founding member of the human sirtuin family of enzymes which control the aging
process. Specifically, SRT501 acts by increasing mitochondrial activity and
therefore is targeted to address metabolic diseases, such as Type 2 Diabetes.

"This is the first time that a small molecule targeting sirtuins, the genes
which control the aging process, has shown efficacy in a disease of aging," said
Peter Elliott, Ph.D., Senior Vice President of Development at Sirtris. "These
Phase 1b study results are an important step forward for Sirtris because they
represent significant progress in our clinical development of sirtuin
therapeutics. We are very pleased to see the safety profile observed in
preclinical studies translate into a well-tolerated drug molecule in patients,
and we are very encouraged by the glucose lowering effects measured in the oral
glucose test."

Christoph Westphal, M.D., Ph.D., CEO and Vice Chair of Sirtris added, "Effective
treatment for Type 2 Diabetes, a disease of aging, is an unmet medical need and
sirtuin therapeutics may offer significant potential. SRT501 may represent a
promising treatment option for these patients. We look forward to obtaining the
results from our other Phase 1b clinical trial and the results from our Phase 2a
clinical trial later this year."



#2 Hedgehog

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Posted 07 January 2008 - 11:36 PM

I got this from a Scottrade email:

Cheers!
A

CAMBRIDGE, Mass., Jan 07, 2008 (BUSINESS WIRE) -- Sirtris Pharmaceuticals, Inc.
(NASDAQ: SIRT), a biopharmaceutical company focused on discovering and
developing small molecule drugs to treat diseases of aging such as Type 2
Diabetes, announced today that the Company's first product to enter the clinic,
SRT501, was found to be safe and well-tolerated, and was found to significantly
lower glucose in an oral glucose tolerance test conducted as part of a 28 day
Phase 1b clinical study in patients with Type 2 Diabetes. These data were
presented at the 26th Annual JPMorgan Healthcare Conference on Monday, January
7th 2008 at 1:30 pm PST in San Francisco.

This 28-day Phase 1b study was designed to assess the safety, tolerability and
pharmacokinetics of once-daily, orally administered doses of either 2.5 g or 5 g
of SRT501 in patients with Type 2 Diabetes who were naive to other diabetes drug
treatments. Both doses of SRT501 were found to be safe and well-tolerated, and
pharmacokinetics, a measure of drug levels in the blood, were identical at days
one and 28, suggesting no drug accumulation. There were no serious adverse
events and no dose-related adverse events. Importantly, SRT501 showed a
statistically significant improvement in an oral glucose tolerance test on day
28 at two hours and a trend towards lower fasting plasma glucose levels.

SRT501 is also being tested in patients with Type 2 Diabetes in a Phase 1b BID
(twice daily administration) study and in a Phase 2a study in combination with
metformin, the current first-line therapy for Type 2 Diabetes. SIRT1 is the
founding member of the human sirtuin family of enzymes which control the aging
process. Specifically, SRT501 acts by increasing mitochondrial activity and
therefore is targeted to address metabolic diseases, such as Type 2 Diabetes.

"This is the first time that a small molecule targeting sirtuins, the genes
which control the aging process, has shown efficacy in a disease of aging," said
Peter Elliott, Ph.D., Senior Vice President of Development at Sirtris. "These
Phase 1b study results are an important step forward for Sirtris because they
represent significant progress in our clinical development of sirtuin
therapeutics. We are very pleased to see the safety profile observed in
preclinical studies translate into a well-tolerated drug molecule in patients,
and we are very encouraged by the glucose lowering effects measured in the oral
glucose test."

Christoph Westphal, M.D., Ph.D., CEO and Vice Chair of Sirtris added, "Effective
treatment for Type 2 Diabetes, a disease of aging, is an unmet medical need and
sirtuin therapeutics may offer significant potential. SRT501 may represent a
promising treatment option for these patients. We look forward to obtaining the
results from our other Phase 1b clinical trial and the results from our Phase 2a
clinical trial later this year."


SRT501, a reformulated version of resveratrol with improved bioavailability (11% bioavailability, terminal t1/2 of Posted Image 1 h and an AUC of 10,524 ng h-1 ml-1).

Click HERE to rent this advertising spot to support LongeCity (this will replace the google ad above).

#3 VP.

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Posted 08 January 2008 - 01:35 PM

That settles it then. Resveratrol works in humans. It's something many of us on this board have known for some time. WTG Sirtris!

#4 maxwatt

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Posted 08 January 2008 - 03:16 PM

That settles it then. Resveratrol works in humans. It's something many of us on this board have known for some time. WTG Sirtris!


It's like global warming; now the question is no longer "IF", but "HOW MUCH?"

#5 mike250

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Posted 08 January 2008 - 04:34 PM

would this also apply to people with type-1 Diabetes?

#6 lucid

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Posted 08 January 2008 - 04:42 PM

would this also apply to people with type-1 Diabetes?

People with type one diabetes do not produce insulin and must take insulin everyday inorder to process blood sugars. Arguably, the increased insulin sensitivity found in Resveratrol fed rats would slightly benefit those with type one diabetes over the general population. However, Resveratrol wouldn't help people with type one much more than it helps people without any form of diabetes.

Edited by lucid, 08 January 2008 - 04:43 PM.


#7 inawe

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Posted 08 January 2008 - 07:10 PM

I was trying to find more information on the Sirtris diabetes study. In particular what glucose lowering effect do they see. At about 2 gr/day RSV didn't lower my glucose at all. I don't remember that anybody posting in this forum ever mentioned s/he noticed any glucose lowering either. So, does it only work on diabetics?.
I'll quote a couple of things I did find.
"Although encouraging, this was only a 28-day study of pills to deliver a control, 2.5 gram or five grams of SRT501 each to roughly 30 patients with Type 2 Diabetes in India."
Sirtris is a US company, so why India? It goes with the general trend in outsourcing, I suppose. Outsourcing diabetes in this case.
Also <<Dr Christoph Westphal, CEO and Vice Chair of Sirtris added, ...""We look forward to obtaining the results from our other Phase 1b clinical trial and the results from our Phase 2a clinical trial later this year." If all goes well, SIRT1 activator drugs could be available on the market as early as 2012 or 2013, he estimates.>>
Is this a strategy specially designed for "patients with Type 2 Diabetes who were naive"?
For my part I'll continue to take RSV straight, as the Auwerx mice (well, dissolved in red wine actually). Because I think it does provide some benefits. I'll just have to figure out what's the optimum dosage and how best to handle the laxative effect.

#8 maxwatt

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Posted 08 January 2008 - 09:19 PM

I was trying to find more information on the Sirtris diabetes study. In particular what glucose lowering effect do they see. At about 2 gr/day RSV didn't lower my glucose at all. I don't remember that anybody posting in this forum ever mentioned s/he noticed any glucose lowering either. So, does it only work on diabetics?.
I'll quote a couple of things I did find.
"Although encouraging, this was only a 28-day study of pills to deliver a control, 2.5 gram or five grams of SRT501 each to roughly 30 patients with Type 2 Diabetes in India."
Sirtris is a US company, so why India? It goes with the general trend in outsourcing, I suppose. Outsourcing diabetes in this case.
Also <<Dr Christoph Westphal, CEO and Vice Chair of Sirtris added, ...""We look forward to obtaining the results from our other Phase 1b clinical trial and the results from our Phase 2a clinical trial later this year." If all goes well, SIRT1 activator drugs could be available on the market as early as 2012 or 2013, he estimates.>>
Is this a strategy specially designed for "patients with Type 2 Diabetes who were naive"?
For my part I'll continue to take RSV straight, as the Auwerx mice (well, dissolved in red wine actually). Because I think it does provide some benefits. I'll just have to figure out what's the optimum dosage and how best to handle the laxative effect.


The 2.5 and 5 gram doses of SRT501 they were taking are equivalent to two to 4 times as much much of the kind of resveratrol anyone here has been taking (depending on how it is taken.)

The study did "show a trend" toward lower glucose, according to the reports; hard to tell what this means, but likely it was not statistically significant for this trial, but worth further study.

The cheap glucose meters we have access to are designed for diabetics, and are accurate at the high end of the scale, but I doubt if any of them, especially the ones that require minimal blood to be drawn. are accurate at the low end. Probably none of them will register under 120. I also suspect if your glucose is already low, there is nothing to fix. It isn't surprising no one has reported lowered blood glucose.

If you are taking a quality 98 or 99% pure product, you should not have a problem with a laxative effect.

#9 health_nutty

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Posted 08 January 2008 - 09:34 PM

That settles it then. Resveratrol works in humans. It's something many of us on this board have known for some time. WTG Sirtris!


It shows that it is bioavailable anyhow. We have yet to prove that it activates SIRT1 for humans (in vivo).

#10 inawe

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Posted 09 January 2008 - 12:10 AM

I was trying to find more information on the Sirtris diabetes study. In particular what glucose lowering effect do they see. At about 2 gr/day RSV didn't lower my glucose at all. I don't remember that anybody posting in this forum ever mentioned s/he noticed any glucose lowering either. So, does it only work on diabetics?.
I'll quote a couple of things I did find.
"Although encouraging, this was only a 28-day study of pills to deliver a control, 2.5 gram or five grams of SRT501 each to roughly 30 patients with Type 2 Diabetes in India."
Sirtris is a US company, so why India? It goes with the general trend in outsourcing, I suppose. Outsourcing diabetes in this case.
Also <<Dr Christoph Westphal, CEO and Vice Chair of Sirtris added, ...""We look forward to obtaining the results from our other Phase 1b clinical trial and the results from our Phase 2a clinical trial later this year." If all goes well, SIRT1 activator drugs could be available on the market as early as 2012 or 2013, he estimates.>>
Is this a strategy specially designed for "patients with Type 2 Diabetes who were naive"?
For my part I'll continue to take RSV straight, as the Auwerx mice (well, dissolved in red wine actually). Because I think it does provide some benefits. I'll just have to figure out what's the optimum dosage and how best to handle the laxative effect.


The 2.5 and 5 gram doses of SRT501 they were taking are equivalent to two to 4 times as much much of the kind of resveratrol anyone here has been taking (depending on how it is taken.)

The study did "show a trend" toward lower glucose, according to the reports; hard to tell what this means, but likely it was not statistically significant for this trial, but worth further study.

The cheap glucose meters we have access to are designed for diabetics, and are accurate at the high end of the scale, but I doubt if any of them, especially the ones that require minimal blood to be drawn. are accurate at the low end. Probably none of them will register under 120. I also suspect if your glucose is already low, there is nothing to fix. It isn't surprising no one has reported lowered blood glucose.

If you are taking a quality 98 or 99% pure product, you should not have a problem with a laxative effect.

I'm taking a product that scored better than 99% of trans-RSV, both in China and at a US lab.
My fasting glucose is in the 90s and I'll like it to be lower. I check it twice a year at a local lab for $10. The RSV I take didn't move it.
I remember some other Imminst members mentioned the laxative effect. And according to some researchers it's to be expected:
-----------------------------------------------------------------------
Clin Cancer Res. 2005 Aug 1;11(15):5651-6.
The chemopreventive agent resveratrol stimulates cyclic AMP-dependent chloride secretion in vitro.Blumenstein I, Keserü B, Wolter F, Stein J.
Division of Gastroenterology and Clinical Nutrition, 1 Department of Medicine, ZAFES, J.W. Goethe-Universität, Theodor-Stern-Kai 7, Frankfort on the Main, Germany.

Resveratrol and its analogs are promising cancer chemoprevention agents, currently under investigation in clinical trials. However, patients administered other plant polyphenols experienced severe diarrhea, likely due to an increase in intracellular cyclic AMP (cAMP). Resveratrol itself raises intracellular cAMP levels in breast cancer cells in vitro. Its future use as a cancer chemopreventive agent could therefore be compromised by its severe side effects. The aim of the study was (a) to define the influence of resveratrol on intestinal Cl(-) secretion and (b) to elucidate possible intracellular transduction pathways involved. Resveratrol caused a dose- and time-dependent increase in DeltaIsc in T(84) cells. The specificity of resveratrol was confirmed by using piceatannol 100 mumol/L, the hydroxylated resveratrol analog, which did not alter DeltaIsc. A significant elevation of [cAMP](i) by resveratrol was assessed in T(84) cells. In mouse jejunum, resveratrol induced a time- and dose-dependent increase in DeltaIsc as well. In bilateral Cl(-)-free medium, as well as after inhibition of protein kinase A, resveratrol-induced DeltaIsc was reduced significantly. Preincubation of T(84) cells with butyrate 2 mmol/L (24 and 48 hours) significantly inhibited resveratrol as well as forskolin-induced Cl(-) secretion. In summary, the main mechanism of action of resveratrol in intestinal epithelia is cAMP-induced chloride secretion which can be suppressed by butyrate. It can therefore be suggested that in cancer chemoprevention, both agents should be combined to reduce an undesired side effect such as diarrhea and to benefit from the known agonistic effect of both agents on differentiation of colon cancer cells.

PMID: 16061885 [PubMed - indexed for MEDLINE]
---------------------------------------------------------------
From what I read and the little I understood, it seems to me that RSV acts positively on several different pathways (except the intestinal epithelia cAMP-induced chloride secretion). All of these effects are slight (if one was large Sirtris would be enforcing its patent and making a fortune). So my view is that RSV is not a cure all or a youth elixir, but it's worth taking.

#11 maxwatt

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Posted 09 January 2008 - 01:02 PM

....In summary, the main mechanism of action of resveratrol in intestinal epithelia is cAMP-induced chloride secretion which can be suppressed by butyrate. It can therefore be suggested that in cancer chemoprevention, both agents should be combined to reduce an undesired side effect such as diarrhea and to benefit from the known agonistic effect of both agents on differentiation of colon cancer cells.

PMID: 16061885 [PubMed - indexed for MEDLINE]
---------------------------------------------------------------
From what I read and the little I understood, it seems to me that RSV acts positively on several different pathways (except the intestinal epithelia cAMP-induced chloride secretion). All of these effects are slight (if one was large Sirtris would be enforcing its patent and making a fortune). So my view is that RSV is not a cure all or a youth elixir, but it's worth taking.


That abstract clears up a lot of things. A few people have reported consistent diarrhea on pure resveratrol, more have reported inconsistent effects, including myself. The abstract suggests a remedy: butyrate. There are some butyrate supplements available, but I've no idea of the dosage or the best form. I know an herbalist who has come up with a combination of herbs to combat this effect in herself, but I do not know what herbs she is using.

#12 inawe

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Posted 09 January 2008 - 05:03 PM

....In summary, the main mechanism of action of resveratrol in intestinal epithelia is cAMP-induced chloride secretion which can be suppressed by butyrate. It can therefore be suggested that in cancer chemoprevention, both agents should be combined to reduce an undesired side effect such as diarrhea and to benefit from the known agonistic effect of both agents on differentiation of colon cancer cells.

PMID: 16061885 [PubMed - indexed for MEDLINE]
---------------------------------------------------------------
From what I read and the little I understood, it seems to me that RSV acts positively on several different pathways (except the intestinal epithelia cAMP-induced chloride secretion). All of these effects are slight (if one was large Sirtris would be enforcing its patent and making a fortune). So my view is that RSV is not a cure all or a youth elixir, but it's worth taking.


That abstract clears up a lot of things. A few people have reported consistent diarrhea on pure resveratrol, more have reported inconsistent effects, including myself. The abstract suggests a remedy: butyrate. There are some butyrate supplements available, but I've no idea of the dosage or the best form. I know an herbalist who has come up with a combination of herbs to combat this effect in herself, but I do not know what herbs she is using.

I have been taking Butyrate for a while, since I read that paper. I'm taking the BodyBio, Calcium/Magnesium Butyrate complex, www.e-lyte.com. They recommend to take 6 capsules a day for a total of 3.6 gr of Butyric acid. I don't like to overdue things so I'm taking half of that, but it didn't completely solve the problem. Guess I'll have to go for the full 6 cap/day.

#13 Hedgehog

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Posted 13 January 2008 - 07:08 PM

I was trying to find more information on the Sirtris diabetes study. In particular what glucose lowering effect do they see. At about 2 gr/day RSV didn't lower my glucose at all. I don't remember that anybody posting in this forum ever mentioned s/he noticed any glucose lowering either. So, does it only work on diabetics?.
I'll quote a couple of things I did find.
"Although encouraging, this was only a 28-day study of pills to deliver a control, 2.5 gram or five grams of SRT501 each to roughly 30 patients with Type 2 Diabetes in India."
Sirtris is a US company, so why India? It goes with the general trend in outsourcing, I suppose. Outsourcing diabetes in this case.
Also <<Dr Christoph Westphal, CEO and Vice Chair of Sirtris added, ...""We look forward to obtaining the results from our other Phase 1b clinical trial and the results from our Phase 2a clinical trial later this year." If all goes well, SIRT1 activator drugs could be available on the market as early as 2012 or 2013, he estimates.>>
Is this a strategy specially designed for "patients with Type 2 Diabetes who were naive"?
For my part I'll continue to take RSV straight, as the Auwerx mice (well, dissolved in red wine actually). Because I think it does provide some benefits. I'll just have to figure out what's the optimum dosage and how best to handle the laxative effect.


The 2.5 and 5 gram doses of SRT501 they were taking are equivalent to two to 4 times as much much of the kind of resveratrol anyone here has been taking (depending on how it is taken.)

The study did "show a trend" toward lower glucose, according to the reports; hard to tell what this means, but likely it was not statistically significant for this trial, but worth further study.

The cheap glucose meters we have access to are designed for diabetics, and are accurate at the high end of the scale, but I doubt if any of them, especially the ones that require minimal blood to be drawn. are accurate at the low end. Probably none of them will register under 120. I also suspect if your glucose is already low, there is nothing to fix. It isn't surprising no one has reported lowered blood glucose.

If you are taking a quality 98 or 99% pure product, you should not have a problem with a laxative effect.



"This 28-day Phase 1b study was designed to assess the safety, tolerability and pharmacokinetics of once-daily, orally administered doses of either 2.5 g or 5 g of SRT501"


We still don't know how much Resveratrol is in a gram of their formulation? If you assume it is lecithin you have to account its formula weight and mole ratio to resveratrol they are using. So maybe it it is 2 moles lecithin to 1 mole resveratrol

lecithin 825g/mol
Resveratrol 230g/mol

So if you assume you need 2 parts lecithin to 1 part resveratrol for a 1.8g dose of you are getting only 230mg of resveratrol! Dose anybody know the mol ratios that are needed?

#14 edward

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Posted 14 January 2008 - 01:05 AM

I was trying to find more information on the Sirtris diabetes study. In particular what glucose lowering effect do they see. At about 2 gr/day RSV didn't lower my glucose at all. I don't remember that anybody posting in this forum ever mentioned s/he noticed any glucose lowering either. So, does it only work on diabetics?.
I'll quote a couple of things I did find.
"Although encouraging, this was only a 28-day study of pills to deliver a control, 2.5 gram or five grams of SRT501 each to roughly 30 patients with Type 2 Diabetes in India."
Sirtris is a US company, so why India? It goes with the general trend in outsourcing, I suppose. Outsourcing diabetes in this case.
Also <<Dr Christoph Westphal, CEO and Vice Chair of Sirtris added, ...""We look forward to obtaining the results from our other Phase 1b clinical trial and the results from our Phase 2a clinical trial later this year." If all goes well, SIRT1 activator drugs could be available on the market as early as 2012 or 2013, he estimates.>>
Is this a strategy specially designed for "patients with Type 2 Diabetes who were naive"?
For my part I'll continue to take RSV straight, as the Auwerx mice (well, dissolved in red wine actually). Because I think it does provide some benefits. I'll just have to figure out what's the optimum dosage and how best to handle the laxative effect.


The 2.5 and 5 gram doses of SRT501 they were taking are equivalent to two to 4 times as much much of the kind of resveratrol anyone here has been taking (depending on how it is taken.)

The study did "show a trend" toward lower glucose, according to the reports; hard to tell what this means, but likely it was not statistically significant for this trial, but worth further study.

The cheap glucose meters we have access to are designed for diabetics, and are accurate at the high end of the scale, but I doubt if any of them, especially the ones that require minimal blood to be drawn. are accurate at the low end. Probably none of them will register under 120. I also suspect if your glucose is already low, there is nothing to fix. It isn't surprising no one has reported lowered blood glucose.

If you are taking a quality 98 or 99% pure product, you should not have a problem with a laxative effect.



"This 28-day Phase 1b study was designed to assess the safety, tolerability and pharmacokinetics of once-daily, orally administered doses of either 2.5 g or 5 g of SRT501"


We still don't know how much Resveratrol is in a gram of their formulation? If you assume it is lecithin you have to account its formula weight and mole ratio to resveratrol they are using. So maybe it it is 2 moles lecithin to 1 mole resveratrol

lecithin 825g/mol
Resveratrol 230g/mol

So if you assume you need 2 parts lecithin to 1 part resveratrol for a 1.8g dose of you are getting only 230mg of resveratrol! Dose anybody know the mol ratios that are needed?


This is a good point:

"This 28-day Phase 1b study was designed to assess the safety, tolerability and pharmacokinetics of once-daily, orally administered doses of either 2.5 g or 5 g of SRT501"


This 2.5 g or 5 g or SRT501 could only mean 1 or 2 grams of the actual Resveratrol component while the rest of the mass could be the lecithin or Tween or PEG or whatever... therefore the doses may not be as high as we think.

No I don't know the molar ratio of Res to Surfactant. BTW I thought the surfactant they were using was Tween 80 not lecithin, regardless the same concept applies.

#15 edward

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Posted 14 January 2008 - 01:08 AM

I also find it interesting that they are using once daily dosing for this study. Comments?

#16 sUper GeNius

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Posted 14 January 2008 - 01:25 AM

I also find it interesting that they are using once daily dosing for this study. Comments?


I remember reading in Sirtris literature that later they would experiment with other daily dosing regimens. It seems they don't really know just how many doses per day is best.

#17 Hedgehog

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Posted 14 January 2008 - 06:18 AM

BTW I thought the surfactant they were using was Tween 80 not lecithin, regardless the same concept applies.


Tween? Maybe... have you ever used that stuff? It is super viscous and sticky at room temperature. At work we HATE using this stuff, you have to wait at least 30mins for it to dissolve in warm water. However, after you dissovle Tween 80 I think it stays in solution so I guess you could then add Resveratrol after it cools.


If anybody knows anything about patents could you please PM me. Thanks.

~Hedgehog

PS, if you hear anything about the Hedgehog Pathway that is how I got my SN.

#18 edward

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Posted 15 January 2008 - 03:46 AM

BTW I thought the surfactant they were using was Tween 80 not lecithin, regardless the same concept applies.


Tween? Maybe... have you ever used that stuff? It is super viscous and sticky at room temperature. At work we HATE using this stuff, you have to wait at least 30mins for it to dissolve in warm water. However, after you dissovle Tween 80 I think it stays in solution so I guess you could then add Resveratrol after it cools.


If anybody knows anything about patents could you please PM me. Thanks.

~Hedgehog

PS, if you hear anything about the Hedgehog Pathway that is how I got my SN.


No I haven't used Tween 80, here is where we discussed the surfactant used in SRT501 and the conclusion was that it was Tween 80 (polysorbate 80)... Take a look at the thread and see what you think:

http://www.imminst.o...mp;#entry174523

A couple people tried to use Tween 80 but I don't think they knew how to use it properly (neither do I) plus it apparently tasted disgusting so it was abandoned for the easy to mix and virtually tasteless PEG (and the harder to mix but also not disgusting lecithin). I was interested in getting Tween but ended up not ordering it after reading this thread.

Hedgehog, how would you go about using Tween 80? If it stays in solution could one make up a large batch and then store it in a bottle and pour out the needed amount each day to be mixed with Resveratrol, or would one have to make up a fresh batch each day? Personally I could deal with the "disgusting taste" if I knew how to use it properly and didnt have to make a new batch each day.

#19 Hedgehog

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Posted 15 January 2008 - 04:01 AM

Hedgehog, how would you go about using Tween 80? If it stays in solution could one make up a large batch and then store it in a bottle and pour out the needed amount each day to be mixed with Resveratrol, or would one have to make up a fresh batch each day? Personally I could deal with the "disgusting taste" if I knew how to use it properly and didnt have to make a new batch each day.

well if I had to explain what Tween is like at room temp I would say it's like cold syrup!
Typical you would want to heat up some water (hot to the touch) and add your Tween and then stir the hell out of it. I personally have never tasted it. After you make your "stock" solution you could add it to a larger volume if needed. I don't know how long it will last. I would say make a new batch once a week or maybe once every two weeks. As long as you are clean it shouldn't go bad. If you kept it cold I would even say maybe 2mo. Add your res everyday.

#20 bixbyte

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Posted 07 February 2008 - 06:09 AM

SRT501, a reformulated version of resveratrol with improved bioavailability (11% bioavailability, terminal t1/2 of Posted Image 1 h and an AUC of 10,524 ng h-1 ml-1).



Hh do you think it is posible to make a better resveratrol formula?

#21 bixbyte

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Posted 10 February 2008 - 03:50 AM

Christoph Westphal, M.D., Ph.D., CEO and Vice Chair of Sirtris added, "Effective
treatment for Type 2 Diabetes, a disease of aging, is an unmet medical need
and
sirtuin therapeutics may offer significant potential. SRT501 may represent a
promising treatment option for these patients. We look forward to obtaining the
results from our other Phase 1b clinical trial and the results from our Phase 2a
clinical trial later this year."[/quote]
[/quote]

Anthony,

How about educating Diabetes type IIers about Exercise and Diet?
Lose a certain amount of weight and Type II just goes away.
Save a fortune on medical bills.

so simple,

Bix

#22 Anthony_Loera

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Posted 10 February 2008 - 04:35 AM

I know Bix,

But I don't really exercise at all, so who would listen to me about exercise? :D

Besides, I figure most people who have seen the "Biggest loser" would get the message about exercise, but for some reason it still doesn't click or people simply find it difficult to create new healthy habits. I think most people try, and then fall back on old habits.

I hate to say it, but many people will buy a pill before making a healthy change in their lifestyle.

A

#23 dehbleh

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Posted 10 February 2008 - 04:37 AM

Anthony,

How about educating Diabetes type IIers about Exercise and Diet?
Lose a certain amount of weight and Type II just goes away.
Save a fortune on medical bills.

so simple,

Bix


So naive,

The problem doesn't simply "vanish" when you lose the weight (and do the exercise). It is something that needs to be controlled for the rest of one's life. Yes, I'll agree the symptoms of Type-2 Diabetes can be controlled to a large extent, but for many the underlying damage is still there.

#24 niner

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Posted 10 February 2008 - 06:26 AM

Christoph Westphal, M.D., Ph.D., CEO and Vice Chair of Sirtris added, "Effective
treatment for Type 2 Diabetes, a disease of aging, is an unmet medical need
and
sirtuin therapeutics may offer significant potential. SRT501 may represent a
promising treatment option for these patients. We look forward to obtaining the
results from our other Phase 1b clinical trial and the results from our Phase 2a
clinical trial later this year."


How about educating Diabetes type IIers about Exercise and Diet?
Lose a certain amount of weight and Type II just goes away.
Save a fortune on medical bills.

I'm not sure if Sirtris really cares that much about diabetes. They would be going up against a number of other drugs for that indication. I think the real hope is that they will have an aging drug. You can't presently get a drug approved for aging, as it's not considered a disease. (Changing this mindset would be nice...) So if Sirtris can get it approved for Diabetes, or MELAS, or whatever, then doctors can prescribe it "off label" for aging, or athletic performance, toenail fungus or whatever. And if it turned out to be a great diabetes drug, well, so much the better.

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#25 bixbyte

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Posted 10 February 2008 - 10:08 PM

I'm not sure if Sirtris really cares that much about diabetes. They would be going up against a number of other drugs for that indication. I think the real hope is that they will have an aging drug. You can't presently get a drug approved for aging, as it's not considered a disease. (Changing this mindset would be nice...) So if Sirtris can get it approved for Diabetes, or MELAS, or whatever, then doctors can prescribe it "off label" for aging, or athletic performance, toenail fungus or whatever. And if it turned out to be a great diabetes drug, well, so much the better.



Sirtris is attempting to gain FDA approval their secret Resveratrol formula for Diabetes:

The development of SRT501, a proprietary formulation of resveratrol. We believe that resveratrol lacks the stability and bioavailability necessary to produce optimal therapeutic effects. We are developing SRT501 as a stable and bioavailable formulation of resveratrol that we believe is suitable for pharmaceutical development. Using SRT501 in mice, we are able to achieve an average of almost four times the level of resveratrol in the blood compared with administration of unformulated resveratrol, after adjusting for differences in

dosage levels. In animal models of Type 2 Diabetes, SRT501 reduces weight gain, fasted glucose levels, and fed insulin levels, although these results have not been shown, and may not be achieved, in humans. In 2006, we completed two Phase 1a studies in healthy male volunteers using SRT501, and, based upon favorable results, initiated two Phase 1b studies in Type 2 diabetics using SRT501. SRT501 has also demonstrated an ability to increase the function of intracellular structures called mitochondria in mouse skeletal muscle, and may be suitable as a therapy for rare mitochondrial diseases, such as MELAS.




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