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T4N5 Liposome Lotion (Dimericine)


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#1 Eva Victoria

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Posted 29 January 2008 - 08:39 AM


The AGI Dermatics lead compound is T4N5 Liposome Lotion, known as Dimericine. This drug encapsulates the DNA repair enzyme T4 endonuclease V in a liposome engineered to deliver the enzyme into cells of the skin. Studies in cell cultures and animals indicate T4N5 liposomes increased repair of DNA damage caused by UV. In clinical testing in xeroderma pigmentosum (XP), a genetic disease predisposing to skin cancer, Dimericine reduced the incidence of pre-malignant actinic keratosis and basal cell carcinoma (The Lancet 357:926, 2001).

The drug is currently in clinical testing in the reduction of skin cancer in organ transplant patients, and in patients with a history of skin cancer or pre-malignant skin cancer.

Edit: removed commercial content.

Edited by niner, 31 January 2008 - 03:57 AM.


#2 niner

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Posted 30 January 2008 - 03:56 AM

This drug encapsulates the DNA repair enzyme T4 endonuclease V in a liposome engineered to deliver the enzyme into cells of the skin. Studies in cell cultures and animals indicate T4N5 liposomes increased repair of DNA damage caused by UV. In clinical testing in xeroderma pigmentosum (XP), a genetic disease predisposing to skin cancer, Dimericine reduced the incidence of pre-malignant actinic keratosis and basal cell carcinoma (The Lancet 357:926, 2001).
The drug is currently in clinical testing in the reduction of skin cancer in organ transplant patients, and in patients with a history of skin cancer or pre-malignant skin cancer.

An interesting development. I wonder if it will really make much difference to people with normal DNA repair mechanisms, as opposed to XP patients with compromised repair. From the name, I'm guessing that this enzyme goes after thymine-thymine dimers. Is there any evidence that TT dimers hang around a long time? It seems like the market for this product would be existing damage, as you could avoid new damage by judicious use of sunscreens. It also seems like something that would be more expensive gram for gram than gold...

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#3 Eva Victoria

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Posted 30 January 2008 - 08:31 AM

This drug encapsulates the DNA repair enzyme T4 endonuclease V in a liposome engineered to deliver the enzyme into cells of the skin. Studies in cell cultures and animals indicate T4N5 liposomes increased repair of DNA damage caused by UV. In clinical testing in xeroderma pigmentosum (XP), a genetic disease predisposing to skin cancer, Dimericine reduced the incidence of pre-malignant actinic keratosis and basal cell carcinoma (The Lancet 357:926, 2001).
The drug is currently in clinical testing in the reduction of skin cancer in organ transplant patients, and in patients with a history of skin cancer or pre-malignant skin cancer.

An interesting development. I wonder if it will really make much difference to people with normal DNA repair mechanisms, as opposed to XP patients with compromised repair. From the name, I'm guessing that this enzyme goes after thymine-thymine dimers. Is there any evidence that TT dimers hang around a long time? It seems like the market for this product would be existing damage, as you could avoid new damage by judicious use of sunscreens. It also seems like something that would be more expensive gram for gram than gold...


Even healthy DNA cannot repair all the damage that is caused by every day sun-exposure :( Even if it is not more than 2 minutes!
This drug is actually called the "day after" which will allow you to repair the damage from UV-rays ;)
Since it will be an RX drug in countries where the state pays most of the cost (like in Europe) this drug will not cost more than £5,5/item (appr. $8) :)
The question is: how long the FDA will sit on the decision? :)

#4 edward

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Posted 31 January 2008 - 12:20 AM

Even healthy DNA cannot repair all the damage that is caused by every day sun-exposure :( Even if it is not more than 2 minutes!
This drug is actually called the "day after" which will allow you to repair the damage from UV-rays ;)
Since it will be an RX drug in countries where the state pays most of the cost (like in Europe) this drug will not cost more than £5,5/item (appr. $8) :)
The question is: how long the FDA will sit on the decision? :)


Our FDA can sit on things for a looooonnnnngggg time. Especially if it is purely cosmetic and doesn't have clinical applications for an actual life threatening disease (we are not talking prevention here we are talking about after you have full blown skin cancer or something)

So all Europeans will have beautiful flawless skin with there $8 miracle drug while us heathen Americans will wrinkle and spot like prunes or pay an arm and a leg to import the stuff on the "grey" market....doesnt seem fair. :(

#5 Eva Victoria

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Posted 04 February 2008 - 05:20 PM

Even healthy DNA cannot repair all the damage that is caused by every day sun-exposure :( Even if it is not more than 2 minutes!
This drug is actually called the "day after" which will allow you to repair the damage from UV-rays :)
Since it will be an RX drug in countries where the state pays most of the cost (like in Europe) this drug will not cost more than £5,5/item (appr. $8) ;)
The question is: how long the FDA will sit on the decision? ;)


Our FDA can sit on things for a looooonnnnngggg time. Especially if it is purely cosmetic and doesn't have clinical applications for an actual life threatening disease (we are not talking prevention here we are talking about after you have full blown skin cancer or something)

So all Europeans will have beautiful flawless skin with there $8 miracle drug while us heathen Americans will wrinkle and spot like prunes or pay an arm and a leg to import the stuff on the "grey" market....doesnt seem fair. :(


Nope :( Maybe a new HealthCare system will help? With state subsidiaries in health care, maybe a state owned health care insurance policy and not giving so much cut to the pharm. industry would be a try ;)
See Michael More: Sicko
Sicko - Michael Moore Cut This Scene (No One Would Believe) /And it is true! I am from Norway and it is how it is HERE!!!:)/


#6 dannov

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Posted 27 February 2008 - 08:35 AM

Even healthy DNA cannot repair all the damage that is caused by every day sun-exposure :( Even if it is not more than 2 minutes!
This drug is actually called the "day after" which will allow you to repair the damage from UV-rays :)
Since it will be an RX drug in countries where the state pays most of the cost (like in Europe) this drug will not cost more than £5,5/item (appr. $8) :)
The question is: how long the FDA will sit on the decision? :p


Our FDA can sit on things for a looooonnnnngggg time. Especially if it is purely cosmetic and doesn't have clinical applications for an actual life threatening disease (we are not talking prevention here we are talking about after you have full blown skin cancer or something)

So all Europeans will have beautiful flawless skin with there $8 miracle drug while us heathen Americans will wrinkle and spot like prunes or pay an arm and a leg to import the stuff on the "grey" market....doesnt seem fair. :(


Nope :( Maybe a new HealthCare system will help? With state subsidiaries in health care, maybe a state owned health care insurance policy and not giving so much cut to the pharm. industry would be a try :)
See Michael More: Sicko
Sicko - Michael Moore Cut This Scene (No One Would Believe) /And it is true! I am from Norway and it is how it is HERE!!!:)/


We're $57 trillion in debt, the last thing we need is forced healthcare. Where is that money coming from? Before Nixon got HMOs involved to rob Americans, prescriptions were cheap, doctors would negotiate prices with patients, and nobody was punked around by pharmaceuticals with threats to lose funding should they not reach a certain quota of prescriptions of x and y drug to patient. National Healthcare in America would just be corporate welfaritism. Free Market Capitalism is already under a great enough attack in the medical community.

I'd be perfectly content paying a few bucks ($8 is nothing) for the cream from another country.




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