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SIRT1 Activation Can Suppress Tumor Formation and Growth


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#1 VP.

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Posted 21 February 2008 - 06:30 AM


This PR notice came out from Sirtris this morning. The stock was down today so I don't know how important it is.

Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical company focused on discovering and developing small molecule drugs to treat diseases of aging, announced that Sirtris co-founder David Sinclair, PhD, Harvard Medical School Associate Professor of Pathology, will present data showing that SIRT1 activation can suppress tumor formation and growth in the intestine and colon in a preclinical model of colon cancer. These are the first in-vivo data showing that SIRT1 overexpression can suppress tumor formation and growth. These data are the work of Sirtris Scientific Advisory Board co-chairs Sinclair and Leonard Guarente, PhD, the Novartis Professor of Biology at the Massachusetts Institute of Technology.

The presentation will be held on Thursday, February 28 at the J. David Gladstone Institutes, an independent, non-profit biomedical research organization affiliated with the University of California, San Francisco.


http://www.businessw...amp;newsLang=en

#2 VP.

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Posted 21 February 2008 - 03:57 PM

Another PR release this morning and once again the stock is down.

Sirtris... announced today that it will collaborate with the National Cancer Institute to test the anti-cancer impact of Sirtris’ SIRT1 enzyme activators in numerous models of cancer.
“By providing the resources for this study, the National Cancer Institute is accelerating the testing of our compounds in both solid and hematological models of cancer,” said Sirtris Pharmaceuticals Chief Executive Officer and Vice Chair Christoph Westphal, MD, PhD. “Cancer is the second leading cause of age-related mortality, and this study will advance our understanding of SIRT1 activation and its potential anti-cancer properties.”

The study will include SRT501, a proprietary formulation of resveratrol, and multiple compounds from different chemical classes of Sirtris’ new chemical entities, which are 1000 times more potent than resveratrol in in-vitro studies. All of the compounds activate SIRT1, an enzyme that has been shown to have anti-cancer properties in previous preclinical testing.

“I am proud to be teaming again with Tom Sayers, the study’s lead investigator at the National Cancer Institute,” said Peter Elliott, Senior Vice President and Head of Development at Sirtris Pharmaceuticals. “Several years ago Tom and I worked successfully together on the development of the anti-cancer drug Velcade, and now we are exploring an exciting new opportunity for targeting cancers using SIRT1 activators.”

The National Cancer Institute will test the compounds in well-established cancer cell lines which were previously used in the development of novel and existing chemo-therapeutics. The cell lines to be tested include some of the most common cancer types. The program will also test Sirtris’ compounds using in-vivo mouse tumor models to determine if the compounds reduce or limit the growth of the tumor cells.
Previous studies have shown that calorie restriction—a method which has been shown to increase SIRT1 activation—can exert strong tumor suppressor effects in mammals and increase lifespan in organisms. Through direct activation of the SIRT1 enzyme with Sirtris’ compounds, researchers in this study will be able explore the enzyme’s role in tumor suppression along multiple pathways.

http://biz.yahoo.com...05157.html?.v=1

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#3 malbecman

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Posted 21 February 2008 - 05:41 PM

Overall market is down, too, I wouldnt read too much into it. Rising tide lifts all ships, etc, etc.

It will be interesting to hear what data they do present. Sounds like they are starting the publicity music machine to push into other potential benefits from SIRT-1/SRT501/NCE activation......




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