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Resveratrol, DMSO and the mole


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#1 Hedgehog

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Posted 22 February 2008 - 01:50 AM


I was wondering if some of you who use DMSO + Resveratrol could do a little experiment. I was wondering if you could add your DMSO + Resveratrol to a mole that you have on your body. It would be great if you could take a B4 and after pic. I was wondering if the mole will lose its color. Maybe try it for a few weeks?

Edited by hedgehog_info, 22 February 2008 - 02:10 AM.


#2 edward

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Posted 22 February 2008 - 02:46 AM

Posted Image

After topical application of 99% t-res in DMSO. Definite reduction in color.

Note also the more youthful energetic appearance

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#3 edward

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Posted 22 February 2008 - 02:51 AM

Sorry I couldn't resist. :) Playful sense of humor, side effect of life extending lifestyle, also a key to longevity in my opinion :)

On a serious note it does look like an interesting experiment. What is your theory hedgehog?

edit: glaring word choice mistake had to change it

Edited by edward, 22 February 2008 - 06:29 AM.


#4 Hedgehog

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Posted 22 February 2008 - 03:34 AM

Ha ha


Well some anti cancer drugs will change the color of the mole. Resveratrol may or may not. Just thought that if ppl are already using DMSO + Res they could try this one out.

#5 lucid

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Posted 22 February 2008 - 03:38 AM

Moles are benign neoplasms, meaning they lacked a critical component to become malignant. Mitochondrial disfunction is critical for neoplasm survival. Sirtuins have been shown to restore mitochondiral function allowing apoptosis to occur. It should have an anit-'mole' response in a very similiar manner to how it may have an anti-cancerous tumor response.

Resveratrol Induces Extensive Apoptosis by Depolarizing Mitochondrial Membranes and Activating Caspase-9 in Acute Lymphoblastic Leukemia Cells1
Jan Dörrie, Harald Gerauer, Yvonne Wachter and Susan J. Zunino2

The Chair of Genetics, Friedrich-Alexander University of Erlangen-Nürnberg, D91058 Erlangen, Germany

Resveratrol, a plant antibiotic, has been found to have anticancer activity and was recently reported to induce apoptosis in the myeloid leukemia line HL60 by the CD95-CD95 ligand pathway. However, many acute lymphoblastic leukemias (ALLs), particularly of B-lineage, are resistant to CD95-mediated apoptosis. Using leukemia lines derived from patients with pro-B t(4;11), pre-B, and T-cell ALL, we show in this report that resveratrol induces extensive apoptotic cell death not only in CD95-sensitive leukemia lines, but also in B-lineage leukemic cells that are resistant to CD95-signaling. Multiple dose treatments of the leukemic cells with 50 µM resveratrol resulted in >=80% cell death with no statistically significant cytotoxicity against normal peripheral blood mononuclear cells under identical conditions. Resveratrol treatment did not increase CD95 expression or trigger sensitivity to CD95-mediated apoptosis in the ALL lines. Inhibition of CD95-signaling with a CD95-specific antagonistic antibody indicated that CD95-CD95 ligand interactions were not involved in initiating resveratrol-induced apoptosis. However, in each ALL line, resveratrol induced progressive loss of mitochondrial membrane potential as measured by the dual emission pattern of the mitochondria-selective dye JC-1. The broad spectrum caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone failed to block the depolarization of mitochondrial membranes induced by resveratrol, further indicating that resveratrol action was independent of upstream caspase-8 activation via receptor ligation. However, increases in caspase-9 activity ranged from 4- to 9-fold in the eight cell lines after treatment with resveratrol. Taken together, these results point to a general mechanism of apoptosis induction by resveratrol in ALL cells that involves a mitochondria/caspase-9-specific pathway for the activation of the caspase cascade and is independent of CD95-signaling.

http://cancerres.aac...ract/61/12/4731

#6 Hedgehog

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Posted 22 February 2008 - 03:46 AM

Moles are benign neoplasms, meaning they lacked a critical component to become malignant. Mitochondrial disfunction is critical for neoplasm survival. Sirtuins have been shown to restore mitochondiral function allowing apoptosis to occur. It should have an anit-'mole' response in a very similiar manner to how it may have an anti-cancerous tumor response.

yep thus changing the mole back to its original color.

#7 zoolander

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Posted 22 February 2008 - 05:09 PM

a guy name ps2huang use to use the avatar that you are using hedgehog

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#8 Hedgehog

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Posted 22 February 2008 - 05:42 PM

a guy name ps2huang use to use the avatar that you are using hedgehog


Cool, if he is from imminst he probably got it from the imminist avator gallery




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