I was just about to post this, then saw your thread.
We can conclude from this study, assuming it's accurate, that humans need much more resveratrol to achieve clinically significant results than many had hoped, at least in a relatively short time frame, and at least as regards diabetes treatment.
5 grams daily is a lot, and extremely expensive at present. That's a bottle every 6 days of 500 mg 99% potency caps w/ 60 to a bottle, and 5 bottles monthly.
Is anyone even selling t-res at 99% potency above 1 gram per capsule?
The capsule would be more than a little large. One gram would just about fit into a size "000" capsule, which is too big for a significant portion of the population to swallow without difficulty.
Using a powder can bring the cost down considerably, especially purchasing a kilogram at a time.
Powder can be taken with milk or with whey protein, which bring it into solution in a liquid. The binding is not a problem for bioavailability.
Miralax (PEG3350) an also be used as a dispersant to solublize resveratrol. This is more effective if the resveratrol is first stirred into some alcohol, Everclear or vodka or whiskey. Not for everyone. The SRT501 formulations that have been published in the Methods section in one of Sinclair's papers, all use HPMC as a dispersant in liquid. I am currently taking several grams of resveratrol at a time in half a cup of water using HPMC as a dispersant. It doesn't take much, just a smidgeon (less than 1/64th of a teaspoon, about 120 milligrams.) HPMC dissolves better in cold water. I stir it in first, then add resveratrol powder and stir.
There are different kinds of HPMC; the degree of polymeriation is indicated by a numerical suffix. HPMC 4000 is used as a thikener for low-fat salad dressing. HPMC 15 is used as a food coating, and to prevent sugar crystalization in sugar coatings. HPMC 4000 works, but I found HPMC 05 dissolves more readily than 4000. The 4000 tended to form a gel, but still worked. HPMC-05 was easier to stir in. Anthony suggested HPMC 50.
You guys are all demented! You have no clue of what is scientific reasearch or how to interpret a scientif article. You can not distinguish between science and a money making company like Sirtris. Just stop for one moment and THINK!!! Do not take the word of the people directly involved in the business....
Informative note: I buy resveratrol from Sigma for my experiments. That I'm sure it is 99% pure. It has an usable life of 1 year and it has to be kept at -20°C. The lab pays 100Euros for 100mg!!
100Euros for 100mg...
Holy cow!
If you absolutely don't trust the US Lab Tested 99% natural product ... Why don't you try Clariant International Ltd in Muttenz/Switzerland, they have a much better deal on synthetic (>99.5% pure)
...or you can always try Mr. Mulchandani he is always looking for people to pay through the nose... (yes, that last one was an inside joke)
A
Edited by Anthony_Loera, 05 May 2008 - 04:07 AM.
