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elastic fibers causes skin wrinkles in sun-damaged human skin


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#1 Brainbox

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Posted 23 June 2008 - 08:16 AM


Loss of elastic fibers causes skin wrinkles in sun-damaged human skin.Lee JY, Kim YK, Seo JY, Choi CW, Hwang JS, Lee BG, Chang IS, Chung JH.
Skin Research Institute, Amorepacific Corporation/R&D Center, Yongin-si, Gyeonggi-do, Republic of Korea.

BACKGROUND: Although wrinkling is the most obvious sign of aged skin, the detailed pathomechanism of wrinkle development has not been elucidated. OBJECTIVES: In this study, we investigated the role of elastic fibers in the formation of skin wrinkles. METHODS: Loss of elastic fibers was measured quantitatively in the facial skins of subjects representing seven decades, and then compared with wrinkle severities. We also investigated whether topical retinoic acid treatment to photoaged human skin can restore destroyed elastic fiber, and the correlation between wrinkle improvement with increase in elastic fibers in RA-treated facial skin. RESULTS: We found a significant correlation between decreases in the length, width, number and total area of oxytalan fibers and wrinkle severity. Furthermore, we found that topical application of retinoic acid (0.025%) to chronically photodamaged skin regenerated and restored elastic fibers, and that there was a significant positive correlation between the amount of newly regenerated elastic fiber and the wrinkle improvement caused by retinoic acid. CONCLUSIONS: Our results provide an objective insight into the role of elastic fibers in skin wrinkle formation by providing a quantitative correlation between changes in oxytalan fibers and the severity of skin wrinkling.

PMID: 18201872 [PubMed - indexed for MEDLINE]



#2 luminous

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Posted 24 June 2008 - 12:39 AM

Great find, BB! It's amazing that retinoic acid can actually regenerate and restore elastic fibers. This stuff is worth its weight in gold.

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