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Stem cells and plastic surgery...


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#1 Mind

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Posted 25 June 2008 - 04:11 PM


Stem cells could replace plastic surgery

This is great news. If stem cell therapy works and keeps hollywood stars and other rich vain people looking young (even if it is only superficial) it could really boost research and investment in the field.

#2 forever freedom

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Posted 25 June 2008 - 06:43 PM

Heh, yes even for such purposes (ok which actually arent bad at all, most older people want to look younger after all), more research on stem cells is always a positive.

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#3 lunarsolarpower

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Posted 26 June 2008 - 01:25 AM

I wonder what fraction of plastic surgeons are now aware that you make people look younger by restoring the fat to their faces, not by stretching their skin like the head of a drum. I could see advances in this area allowing quite inexpensive cosmetic surgery ($500 or so) that would knock off 10-20 visual years if it's possible to simply inject enriched autologous stem cells into a few predetermined areas and allow natural proliferation to do the rest.

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#4 caston

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Posted 26 June 2008 - 02:21 AM

What would be even better is using stem cells to help people that really do need them like those with childhood leukemia.
Sometimes the stemcells in a childs bone marrow becomes cancerous and the child requires chemotherapy. In such a case if we can make stem cells available
to them for an autologus infusion then we can replace their cancerous bone marrow cells with patient specific and non-cancerous ones.

Of course there might be much better ways than to have treated the child than with chemotherapy (we are hopefully just leaving the dark ages right about now) but there will be many situations where very young people require stem cell transplants as at this stage they are probably the best people suited to them.

http://ouroboros.wor...tial-solutions/

It is very difficult for a right-wing religious group to argue (at least without looking dogmatic) that a stem cell be it placenta, embryonic or SCNT in origin should not be used when it is to save the life of a very young child. Of course all life (be it young or old) is important but lets not start that debate in this thread.

The same technology used to save the lives of the very young can eventually be re purposed to save the rest of us as well.

Of course what we do with our fat cells is our business but I'd like to see more emphasis on rejuvenation of the cardio vascular and neuro muscular skeletal system than cosmetic looks.

Edited by caston, 26 June 2008 - 08:27 AM.


#5 Luna

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Posted 26 June 2008 - 03:43 AM

And how long should we expect those new type of cosmetics to arrive?

#6 Mind

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Posted 28 July 2008 - 06:48 PM

And how long should we expect those new type of cosmetics to arrive?


Not for sure, but I would think stem cell research will be sped up by this type of entry into the field. There is a lot of money in plastic surgery.

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#7 Ethan

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Posted 04 November 2008 - 12:06 AM

I haven't heard the follow-up, but this is defiinetly the beginning of a good trend

http://cosmeticsurge...g-breakthrough/

#8 Mind

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Posted 04 November 2008 - 12:18 AM

Well, that didn't take too long.

#9 lunarsolarpower

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Posted 04 November 2008 - 04:15 AM

I could see advances in this area allowing quite inexpensive cosmetic surgery ($500 or so)


this procedure will cost approximately $5,000


I guess I was only off by one order of magnitude :)

#10 niner

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Posted 04 November 2008 - 04:34 AM

I could see advances in this area allowing quite inexpensive cosmetic surgery ($500 or so)


this procedure will cost approximately $5,000


I guess I was only off by one order of magnitude :)

Not really... $500 probably IS what it costs, just not what they charge you for it.

#11 Luna

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Posted 04 November 2008 - 08:32 AM

The woman in the article looks scary @@..

#12 Gerald W. Gaston

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Posted 04 November 2008 - 02:17 PM

The woman in the article looks scary @@..


Really? To me it seemed like a pretty good looking pic of Marilyn Monroe. I guess to each their own.

#13 Ethan

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Posted 05 November 2008 - 10:06 AM

I don't believe wanting to look young is at all a trival concern. I was out to dinner with my grandparents last week, both of whom are in their 90's and there were some people there who were afraid to look at them or had a slight hesitation in shaking their hands. Most people treat senior citizens like second class citizens. They are a reminder of our own mortality. That must take a huge toll on a person. Wanting to look young, say at least 65 years old or younger is a very healthy mindset.

#14 manofsan

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Posted 29 March 2009 - 04:27 AM

Doctors have announced their ability to take fat cells from a woman's stomach, and turn them into stem cells which can then be implanted in breast tissue for breast enlargement:

http://www.timesonli...icle5993187.ece

The procedure should be available within 6 months.

Ironically, while this procedure is cosmetic rather than lifesaving, I'd predict that the market demand would be so large that it could result in a lot of activity that would boost stem cell knowledge.

#15 niner

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Posted 29 March 2009 - 04:42 AM

Wow. Smaller stomach and bigger boobs? Talk about win-win.

The same technique has been used in Japan for six years, initially to treat women with breast deformities caused by cancer treatment and, more recently, for cosmetic breast augmentation in healthy women.

Hmm. how 'bout that? More evidence that Bush "helped" stem cell research in America?

#16 Hedgehog

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Posted 29 March 2009 - 04:44 AM

Wow. Smaller stomach and bigger boobs? Talk about win-win.

The same technique has been used in Japan for six years, initially to treat women with breast deformities caused by cancer treatment and, more recently, for cosmetic breast augmentation in healthy women.

Hmm. how 'bout that? More evidence that Bush "helped" stem cell research in America?



Will that work on me? =)

#17 valkyrie_ice

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Posted 29 March 2009 - 05:52 AM

OOOOOOOOOOOOOOOOOOHHHHHHHHHH

Val wants!

Seriously, one of the main reasons I have not seriously applied again for sex reassignment is because I don't want to be a barbie doll girl. I'm waiting for true full reassignment with fully functional organs. At forty, I also am hoping rejuvenation arrives at the same time XD. (what can I say, I AM a succubus after all XP )

Still, this is definitely a wonderful step in the right direction. If this truly works well, it shouldn't interfere with breast milk production at all.

And I agree with Manofsan. I lay you odds this will make a huge impact, and not only for breast augmentation. Being able to redistribute fat cells will lead to the first stages of body sculpting. If they can do it for breasts, why not hips, lips, thighs, buttocks, etc? Why be stuck with flabby thighs when you can get rounder hips, bigger tits, and a nice ass instead?

Looks like the New You Salon and The Body Shoppe weren't so far fetched ideas after all, :) :) :-D

#18 manofsan

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Posted 29 March 2009 - 07:39 AM

Wow. Smaller stomach and bigger boobs? Talk about win-win.


I guess nobody's heard of Estradiol then :)

#19 prometheandream

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Posted 03 April 2009 - 12:56 AM

I think this is absolutely one of the most important areas for popularizing life extension among the public. I think cosmetic surgery will be one of the first markets for "legitimate" life extension. Customers of cosmetic surgeons are a natural market for "life extension," both for products and for non-profit solicitations by groups like Methusalah Foundation and ImmInst.

#20 sentrysnipe

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Posted 03 April 2009 - 01:43 AM

They've been doing it in China for years:

Posted Image
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Posted Image

So the Bush "helping" the ban is irrelevant.

Edited by sentrysnipe, 03 April 2009 - 01:45 AM.


#21 TianZi

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Posted 05 April 2009 - 09:11 AM

Sentry,

As a resident of Taiwan, I'm interested in your above post. Please post a link to the site from which you obtained this information. Thanks.

#22 Boondock

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Posted 13 June 2009 - 11:08 PM

A link for the China results would be good. This is the first I've heard of it. With regard to the general idea, the market demand is huge and growing, and the progress so far already seems to be significant. I expect that, as it becomes more available and more effective, social attitudes towards plastic surgery will change. Who now condemns people for having their wonky teeth straightened?

#23 Mind

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Posted 17 August 2009 - 05:27 PM

Stem cell growth factors used to regrow hair.

HSC is a proprietary formulation of naturally secreted embryonic proteins, growth factors and contains the first naturally stabilized, bioactive solution of Wnt proteins and their cofactors, which have been implicated in the induction of new hair follicle formation and growth.

The five-month double-blind, placebo-controlled clinical trial was focused on evaluation of safety in the clinical application of Histogen's Hair Stimulating Complex (HSC), formerly known as ReGenica. The 24 subject clinical trial was designed to examine the safety and efficacy of a single injection of HSC alone, as well as in combination with three different perturbation methods. Quantitative analysis of clinical macrophotography and subject biopsies were utilized to evaluate treatment safety and efficacy.

84.6% of the patients receiving one injection of Histogen's serum-free HSC showed an increase in terminal hair 12 weeks post-injection, with a statistically significant (p<0.05) increase in the number of terminal hairs, cumulative hair thickness density and hair thickness mean. Perturbation did not enhance the results seen with HSC. There were no adverse reactions seen in any of the treated 24 patients at baseline, 12 weeks, or the 22 week endpoint.


More valuable research that could eventually be applied to aging.

#24 Ghostrider

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Posted 21 August 2009 - 06:22 PM

Stem cell growth factors used to regrow hair.

HSC is a proprietary formulation of naturally secreted embryonic proteins, growth factors and contains the first naturally stabilized, bioactive solution of Wnt proteins and their cofactors, which have been implicated in the induction of new hair follicle formation and growth.

The five-month double-blind, placebo-controlled clinical trial was focused on evaluation of safety in the clinical application of Histogen's Hair Stimulating Complex (HSC), formerly known as ReGenica. The 24 subject clinical trial was designed to examine the safety and efficacy of a single injection of HSC alone, as well as in combination with three different perturbation methods. Quantitative analysis of clinical macrophotography and subject biopsies were utilized to evaluate treatment safety and efficacy.

84.6% of the patients receiving one injection of Histogen's serum-free HSC showed an increase in terminal hair 12 weeks post-injection, with a statistically significant (p<0.05) increase in the number of terminal hairs, cumulative hair thickness density and hair thickness mean. Perturbation did not enhance the results seen with HSC. There were no adverse reactions seen in any of the treated 24 patients at baseline, 12 weeks, or the 22 week endpoint.


More valuable research that could eventually be applied to aging.


Yup, I have been watching Histogen's progress and they appear to be the most promising company so far. Intercyex produced similar results with their phase 2 clinical trials, but are having funding issues. Follica is another company working on the same solution, but I have not seen their results. Histogen already sells a skin care rejuvenation lotion for around $100. I asked about it here on the skin care forum a few weeks ago. I have good hair thickness back and sides and getting regrowth to the front. But would definitely like to return to my 15 year old hair line.

Note, if I had money to invest, I would definitely look at Histogen. Hundreds of thousands (millions?) of guys would be willing to pay over $10k-20k (average cost of hair transplant) for a little more hair. The first company that succeeds will become very wealthy.

Edited by Ghostrider, 21 August 2009 - 06:24 PM.


#25 Mind

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Posted 10 December 2012 - 08:13 PM

Coming back to this thread. Even if C60 does not help lengthen human lifespan or healthspan, it does regrow hair, so their might be another market for the product to at least make people look superficially younger.

...and cosmetic surgery strikes again - in a positive way. Researchers recently used a cosmetic surgery filler to restore the skin's extra-cellular matrix (ECM). This caused skin cells to rejuvenate. The question for serious anti-aging researchers is what causes the ECM to "break down" in the first place. Is it the evil glucosepane?

In the new study, scientists from the U-M Department of Dermatology injected the skin of 21 volunteers in their 80s with a filler often used cosmetically to reduce facial wrinkles. The filler bolsters the ECM, filling in the spaces left by aging.
The researchers did not receive funding from the product's manufacturer, nor did they get input on the design or results from the company. Rather, they were using the product as a way to increase the mechanical forces within the volunteers' skin.

They also didn't focus on the face, where skin takes a beating over a lifetime of exposure to ultraviolet light and other insults that break down collagen. Instead, they focused on skin that had almost never seen the light of day -- the buttocks.

The result: over three months, the fibroblasts began expressing collagen-related genes, producing more collagen, and connecting better to the ECM. The entire layer of skin grew thicker, and more blood vessels, which nourished the cells were seen.

"Fragmentation of the extracellular matrix plays an important role in skin aging, but by altering the matrix using an external filler and increasing the internal pressure, we've shown that we can essentially trigger a signal for cells to wake up," says Gary Fisher, Ph.D., the Harry Helfman Professor of Molecular Dermatology and senior author of the new study, published in the Journal of Investigative Dermatology.


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#26 reason

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Posted 11 December 2012 - 12:13 PM

The visible signs of skin aging are reflected by a similar loss of elasticity and function in important tissues inside the body, driven by declining function in stem cells that support these tissues, a steep growth in the number of senescent cells that hamper maintenance of tissue integrity, the accumulation of AGEs - largely glucosepane - and the other mechanisms that cause aging.

These root causes must be dealt with, but comparatively few scientists are trying to tackle them directly. The more usual research focuses on ways to try to patch over consequences by making use of other mechanisms - somewhat akin to trying to deal with a broken dam by bailing rather than fixing the holes. Here researchers manage to reverse a fraction of the effects of skin aging:

[The] extracellular matrix, or ECM, acts like the scaffold that skin cells roost in. It's made of tiny fibrils of collagen, produced by the cells (fibroblasts). Over time, as skin ages, the ECM becomes fragmented, which causes cells to lose their connections to that scaffold - and the lack of support accelerates their decline further. The same thing may happen in other types of tissue.

[Scientists] injected the skin of 21 volunteers in their 80s with a filler often used cosmetically to reduce facial wrinkles. The filler bolsters the ECM, filling in the spaces left by aging. The researchers did not receive funding from the product's manufacturer, nor did they get input on the design or results from the company. Rather, they were using the product as a way to increase the mechanical forces within the volunteers' skin. The result: over three months, the fibroblasts began expressing collagen-related genes, producing more collagen, and connecting better to the ECM. The entire layer of skin grew thicker, and more blood vessels, which nourished the cells were seen.

"Fragmentation of the extracellular matrix plays an important role in skin aging, but by altering the matrix using an external filler and increasing the internal pressure, we've shown that we can essentially trigger a signal for cells to wake up. This shows that skin cells in elderly people have the capacity to respond robustly in a very positive way to alterations in the mechanical property of their environment. We still need to know more about how cells sense their environment, but in general it appears we have made a real difference in the structural integrity of skin."

Link: http://www.scienceda...21210101351.htm


&lt;br&gt; &lt;br&gt;View the full article

#27 pleb

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Posted 13 December 2012 - 05:48 PM

i found this very interesting i will look into this much closer i had intended having a mini S face lift after moving to Mexico,

Mainly so i can chat up the good looking 40 year old women rather than the 60 year old wrinklies that i'm stuck with now, !!! :>)

#28 Mind

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Posted 19 May 2013 - 06:11 PM

We might be able to find out a little more about cutting-edge cosmetic surgery. I have an interview with Cindy Jackson coming up soon.

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#29 Mind

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Posted 26 May 2013 - 01:09 PM

The podcast with Cindy Jackson is now available.

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