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Topical antioxidant solution protects human skin against UV damage


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#1 Fredrik

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Posted 09 July 2008 - 10:12 AM


This is exciting. Another real, albeit small, in vivo study on humans showing substantial UV-protection (2-10 MEDs) from topical C + E +ferulic acid. Not in cell culture or the backs of shaved rats. Does anyone have access to this new paper please? Would love to study it in full.

J Am Acad Dermatol. 2008 Jul 4.

A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.


Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR. Division of Dermatology, Duke University Medical CenterDurham, North Carolina.

BACKGROUND: Skin cancer and photoaging changes result from ultraviolet (UV)-induced oxidative stress. Topical antioxidants may protect skin from these effects.


OBJECTIVE: We sought to determine whether a stable topical formulation of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid (CEFer) could protect human skin in vivo from substantial amounts of solar-simulated UV radiation.


METHODS: CEFer and its vehicle were applied to separate patches of normal-appearing human skin for 4 days. Each patch was irradiated with solar-simulated UV, 2 to 10 minimal erythema doses, at 2-minimal erythema dose intervals. One day later, skin was evaluated for erythema and sunburn cells, and immunohistochemically for thymine dimers and p53. UV-induced cytokine formation, including interleukin (IL)-1alpha, IL-6, IL-8, and IL-10, and tumor necrosis factor-alpha, were evaluated by real-time polymerase chain reaction.


RESULTS: CEFer provided significant and meaningful photoprotection for skin by all methods of evaluation. LIMITATIONS: The number of patients evaluated was relatively small.


CONCLUSION: CEFer provided substantial UV photoprotection for skin. It is particularly effective for reducing thymine dimer mutations known to be associated with skin cancer. Its mechanism of action is different from sunscreens and would be expected to supplement the sun protection provided by sunscreens.

PMID: 18603326


http://www.ncbi.nlm....Pubmed_RVDocSum

Edited by Fredrik, 09 July 2008 - 10:24 AM.

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