Read this one:
http://www.imminst.o...;hl=mebendazole
I wrote a little bit about mebendazole and its action in melanoma, but it was also tested in lung cancer. (1)
Mebendazole was tested in following cells of the human non-small cell lung cancer cell line A549, WI38normal fibroblasts (American Type Culture Collection, Rockville, MD), and human lung cancer cell lines H1299 and H460. It was selective for cancer cells the authors say:
The growth-inhibitory effect was not restricted to lung cancer cells, because MZ also profoundly inhibited the growth of breast, ovary, and colon carcinomas and osteosarcomas, producing IC50s that varied from 0.1 to 0.8 µM (data not shown).
So it would be perhaps also an option in SCLC. In addition with Cimetidine and an oily solution (coconut oil) you could reach higher plasma values needed for this effect. Combined with MJ or derivatives it is an interesting option.
(1)
Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo.
Mukhopadhyay T, Sasaki J, Ramesh R, Roth JA.
Clin Cancer Res. 2002 Sep;8(9):2963-9.
look here:
http://clincancerres...eprint/8/9/2963
I've read the links. I have SCLC, so we don't really know if this research would have any impact.
There's this for NSLC: http://mct.aacrjourn.../full/1/13/1201
Microtubules have a critical role in cell division, and consequently various microtubule inhibitors have been developed as anticancer drugs. In this study, we assess mebendazole (MZ), a microtubule-disrupting anthelmintic that exhibits a potent antitumor property both in vitro and in vivo. Treatment of lung cancer cell lines with MZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release. MZ induces abnormal spindle formation in mitotic cancer cells and enhances the depolymerization of tubulin, but the efficacy of depolymerization by MZ is lower than that by nocodazole. Oral administration of MZ in mice elicited a strong antitumor effect in a s.c. model and reduced lung colonies in experimentally induced lung metastasis without any toxicity when compared with paclitaxel-treated mice. We speculate that tumor cells may be defective in one mitotic checkpoint function and sensitive to the spindle inhibitor MZ. Abnormal spindle formation may be the key factor determining whether a cell undergoes apoptosis, whereas strong microtubule inhibitors elicit toxicity even in normal cells.
Might it be effective for SLC as well?