Finally got my new rig up and running. These were the specs (I went with the EVGA 790i for a motherboard instead though as I could pop in a 3rd card down the road)
Here are the guts. (Those video cards are heavy as a brick!). This snapped together pretty easily in under an hour though getting that giant heat sink atop the cpu was a bit of a bitch.
Hooking up 3 monitors was a breeze with Vista64. 2 plug into the first card, 1 the second.
Both GX2 cards are blazing through WUs now. The instructions for getting the GPU clients working at Stanford's site were very good so getting it configured was fairly easy. These temps seem pretty high but I hear they run hot so not worried as it's helping to heat my house
CPU utilization is around 26% (13% per core), 2 GB or RAM is being used (firefox, iTunes and other junk open) and performance of the system is excellent despite these running in the background.
I had no problems getting drivers and all of the above hardware up and running with Vista 64. I had heard lots of horror stories and was fence sitting 'til now but it seems like Microsoft and most of the hardware manufacturers have worked out a majority of the kinks. Next weekend I'll play around with overclocking the video cards after seeing how they do this week on the PPD.