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any drug that stops mind?


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#1 desperate788

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Posted 25 December 2008 - 01:57 PM


I don't want to think about anything I just want my brain stop. İs there any way of doing this?

#2 Guacamolium

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Posted 25 December 2008 - 03:18 PM

I don't want to think about anything I just want my brain stop. İs there any way of doing this?


Well, you can induce death or to a lessor degree a coma through overdosing on various things to "stop" your brain. Are you actually meaning that you want to slow down and govern the incidence of your thoughts? If so, then you can look into mantra meditation which uses breathing techniques and mental discipline to better control rampant thought generation. Medication-wise you could take benzodiazepines to create a lot of delta wave activity in your brain, but the riskiness of that class of drugs is really high due to dependence and tolerance issues. They also tend to obliterate memory encoding. Meditation has been shown to actually do the opposite.

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#3 bgwithadd

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Posted 25 December 2008 - 04:07 PM

theanine, gotu kola, kava kava, stims in high doses.

#4 medicineman

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Posted 25 December 2008 - 04:13 PM

I don't want to think about anything I just want my brain stop. İs there any way of doing this?


Well, you can induce death or to a lessor degree a coma through overdosing on various things to "stop" your brain. Are you actually meaning that you want to slow down and govern the incidence of your thoughts? If so, then you can look into mantra meditation which uses breathing techniques and mental discipline to better control rampant thought generation. Medication-wise you could take benzodiazepines to create a lot of delta wave activity in your brain, but the riskiness of that class of drugs is really high due to dependence and tolerance issues. They also tend to obliterate memory encoding. Meditation has been shown to actually do the opposite.


what you mean stop your brain? are you having racing thoughts??? have you been on stimulants for a while, or were you on GHB or something similar??? or have you been diagnosed with mania before???? id like to help, but i really don't know what you exactly want... you can't have your brain just stop, thats death. otherwise, if you are looking for halting racing thoughts, and you feel they are acute in nature that they are debilitating your life, you might try, as the gentleman above said, a benzo, but you will want to go on something less functionally debilitating such as valproate. if you are suffering from DA rebound post long term GHB usage, than, this is an extremely tough situation, and you really need medical assisstance for it.

if you are long term stim user, than you have to somehow alter or taper down your stim dosage. I remember being on ephedrine for a while for purposes of exercise, and after using it for a while, i noticed that i would get racing thoughts constantly, and i just wished something would slow my brain down. i think i still get these racing thoughts, and i blame long term stimulant use for it.

extreme cases, your looking at NMDA antagonists . i will refrain from mentioning names since this is an inappropriate forum for it, but if you feel going down that route, than you need medical help.

Edited by medicineman, 25 December 2008 - 04:19 PM.


#5 meursault

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Posted 25 December 2008 - 06:37 PM

meditation will allow you to control and settle your thoughts...a healthy and valuable power

#6 Lufega

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Posted 25 December 2008 - 08:10 PM

Increase magnesium, lower calcium.

#7 desperate788

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Posted 26 December 2008 - 05:16 PM

I don't want to think about anything I just want my brain stop. İs there any way of doing this?


Well, you can induce death or to a lessor degree a coma through overdosing on various things to "stop" your brain. Are you actually meaning that you want to slow down and govern the incidence of your thoughts? If so, then you can look into mantra meditation which uses breathing techniques and mental discipline to better control rampant thought generation. Medication-wise you could take benzodiazepines to create a lot of delta wave activity in your brain, but the riskiness of that class of drugs is really high due to dependence and tolerance issues. They also tend to obliterate memory encoding. Meditation has been shown to actually do the opposite.


Thanks, I always think about something in an obsessive manner. İs it so or the other way this dilemma is always on my mind, causing a mental decline. About meditation all ı can do is simple breathing meditation, does it help? I have intention to upgrage to mindfullness meditation.

#8 desperate788

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Posted 26 December 2008 - 05:23 PM

I don't want to think about anything I just want my brain stop. İs there any way of doing this?


Well, you can induce death or to a lessor degree a coma through overdosing on various things to "stop" your brain. Are you actually meaning that you want to slow down and govern the incidence of your thoughts? If so, then you can look into mantra meditation which uses breathing techniques and mental discipline to better control rampant thought generation. Medication-wise you could take benzodiazepines to create a lot of delta wave activity in your brain, but the riskiness of that class of drugs is really high due to dependence and tolerance issues. They also tend to obliterate memory encoding. Meditation has been shown to actually do the opposite.


what you mean stop your brain? are you having racing thoughts??? have you been on stimulants for a while, or were you on GHB or something similar??? or have you been diagnosed with mania before???? id like to help, but i really don't know what you exactly want... you can't have your brain just stop, thats death. otherwise, if you are looking for halting racing thoughts, and you feel they are acute in nature that they are debilitating your life, you might try, as the gentleman above said, a benzo, but you will want to go on something less functionally debilitating such as valproate. if you are suffering from DA rebound post long term GHB usage, than, this is an extremely tough situation, and you really need medical assisstance for it.

if you are long term stim user, than you have to somehow alter or taper down your stim dosage. I remember being on ephedrine for a while for purposes of exercise, and after using it for a while, i noticed that i would get racing thoughts constantly, and i just wished something would slow my brain down. i think i still get these racing thoughts, and i blame long term stimulant use for it.

extreme cases, your looking at NMDA antagonists . i will refrain from mentioning names since this is an inappropriate forum for it, but if you feel going down that route, than you need medical help.


Yes racing thoughts is my problem, and I try to understand things, think about them but always a dilemma is conclusion, resulting in a mental decline. Benzodiapines are prescribed here, and doctors usually don't want to prescribe them but valproate. It's an anticonvulsant like Phenytoin. İs Phenytoin okey? I think its cheaper. Can you tell me a bit about the mechanism how an antiepileptic may help with racing thoughts?

#9 desperate788

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Posted 26 December 2008 - 05:24 PM

Increase magnesium, lower calcium.


Yes I'm taking magnesium 200mg with 250mg b6, b1. May ı take more magnesium?

#10 rwac

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Posted 26 December 2008 - 05:42 PM

Increase magnesium, lower calcium.


Yes I'm taking magnesium 200mg with 250mg b6, b1. May ı take more magnesium?


You could easily bump it up to 600-800mg Magnesium

Make sure thats an absorbable form, like Citrate, Orotate, Malate, Taurate or Chelate but not Oxide

Edited by rwac, 26 December 2008 - 05:51 PM.


#11 Lotus

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Posted 26 December 2008 - 07:04 PM

Breathing meditation is fine. It's the type of meditation I started with. If that works for you, that's great. There's also using things that make you feel serene, like a picture of something you feel is sacred, listening to soothing music or bird song, being out in nature. I think it's really about is to use different methods or tools that help us let go, in order to really see things as they are, that they're fine as they are and that we don't need to control them. We don't even need to understand them. The sky, or music, or art, or gravity, or trees - they're all perfect and fine whether we understand them or not. Reading zen stuff i find is pretty relaxing too - stuff by Shunryu Suzuki is great.

#12 medicineman

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Posted 26 December 2008 - 08:51 PM

valproate is a mood stabilizer class of drugs. it is used for epilepsy, and seems to work on neuropathic pain. but, i know it is prescribed for people with racing thoughts that is functionally debilitating. Valproate and lamictal, or lamotrigine. Phenytoin is too problematic. It causes liver enzyme derangement, can cause vitb12 depletion, and other problems you dont want.

i would much rather you had a consult with a doctor, and chances are, you will get valproate, or lamictal if your health insurance are of the generous type. i have witnessed valproate do wonders to people with racing thoughts and such that has become unbearable, something bordering mania.

before you go for meds, have your electrolytes and thyroid function checked. if they are normal, than a consult with a psychiatrist concerning your problem would be the best way to go. mention to him if your having any sleep disorders, or symptoms of hyperactivity. ask him about valproate....

the mechanism of valproate cover 3 areas. one is blocking of voltage gated sodium channels in the brain, and hence abnormal neuronal discharge, such as occuring in epilepsy, is diminished. other mechanism, is inhibiting the enzyme responsible for deamination of GABA. Last mechanism, which is unclear, is interfering in the pathway of arachidonic acid. If you know, arachidonic acid is a fatty acid that you dont want too much of anyways. arachidonic acid is a precursor for many substances in the body, and is now recently thought that arachidonic acid might have a connection with neurodegenerative diseases. although the last part is still under investigation. it is an essential fatty acid, but is one of those that can cause biochemical chaos in the brain.

Edited by medicineman, 26 December 2008 - 09:01 PM.


#13 desperate788

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Posted 26 December 2008 - 10:48 PM

Increase magnesium, lower calcium.


Yes I'm taking magnesium 200mg with 250mg b6, b1. May ı take more magnesium?


You could easily bump it up to 600-800mg Magnesium

Make sure thats an absorbable form, like Citrate, Orotate, Malate, Taurate or Chelate but not Oxide


ok, its the right form

#14 pycnogenol

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Posted 26 December 2008 - 10:49 PM

I've heard of this drug called Delysid (Sandoz) that will definitely stop the mind. A few drops is all it takes. :-D

Edited by pycnogenol, 26 December 2008 - 10:53 PM.


#15 desperate788

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Posted 26 December 2008 - 10:52 PM

Breathing meditation is fine. It's the type of meditation I started with. If that works for you, that's great. There's also using things that make you feel serene, like a picture of something you feel is sacred, listening to soothing music or bird song, being out in nature. I think it's really about is to use different methods or tools that help us let go, in order to really see things as they are, that they're fine as they are and that we don't need to control them. We don't even need to understand them. The sky, or music, or art, or gravity, or trees - they're all perfect and fine whether we understand them or not. Reading zen stuff i find is pretty relaxing too - stuff by Shunryu Suzuki is great.


Thank you, zen stuff is about meditation ı think. It's on my study list. It's nice to know I'm not spending half an hour a day for nothing, you say breathing meditation is fine.

#16 desperate788

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Posted 26 December 2008 - 10:55 PM

valproate is a mood stabilizer class of drugs. it is used for epilepsy, and seems to work on neuropathic pain. but, i know it is prescribed for people with racing thoughts that is functionally debilitating. Valproate and lamictal, or lamotrigine. Phenytoin is too problematic. It causes liver enzyme derangement, can cause vitb12 depletion, and other problems you dont want.

i would much rather you had a consult with a doctor, and chances are, you will get valproate, or lamictal if your health insurance are of the generous type. i have witnessed valproate do wonders to people with racing thoughts and such that has become unbearable, something bordering mania.

before you go for meds, have your electrolytes and thyroid function checked. if they are normal, than a consult with a psychiatrist concerning your problem would be the best way to go. mention to him if your having any sleep disorders, or symptoms of hyperactivity. ask him about valproate....

the mechanism of valproate cover 3 areas. one is blocking of voltage gated sodium channels in the brain, and hence abnormal neuronal discharge, such as occuring in epilepsy, is diminished. other mechanism, is inhibiting the enzyme responsible for deamination of GABA. Last mechanism, which is unclear, is interfering in the pathway of arachidonic acid. If you know, arachidonic acid is a fatty acid that you dont want too much of anyways. arachidonic acid is a precursor for many substances in the body, and is now recently thought that arachidonic acid might have a connection with neurodegenerative diseases. although the last part is still under investigation. it is an essential fatty acid, but is one of those that can cause biochemical chaos in the brain.


Thank you very much for your explanations. If Phenytoin does the work ı can use it at this point I don't care about possible side effects. Lamictal is not present in my country, I learned now.

#17 bgwithadd

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Posted 26 December 2008 - 11:45 PM

What are the side effects of valproate, though? The problem is, there are really no good meds out there for anxiety. They all seem have many possible side effects and are sometimes crazily expensive on top of that. I've taken several, and none were remotely tolerable. If you need serious help you might have to go this route but it will be a rough ride to find something that works and doesn't cause more problems than it helps. If you can, it's a hundred times better to find supplements that will work for you as most of them have virtually no side effects taken in recommended doses.

Magnesium is a good bet, won't do wonders but it can be a help. Also, so are ashwagandha and especially bacopa. Even lithium orotate might help a bit. The last three have the benefit of being extremely cheap, too; the only complaint I have about supplements is that many of them are so expensive, and you often find that what works for one person does nothing for you, and get surprised to find things work a lot for you that others don't do as well on.

#18 desperate788

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Posted 27 December 2008 - 02:38 PM

What are the side effects of valproate, though? The problem is, there are really no good meds out there for anxiety. They all seem have many possible side effects and are sometimes crazily expensive on top of that. I've taken several, and none were remotely tolerable. If you need serious help you might have to go this route but it will be a rough ride to find something that works and doesn't cause more problems than it helps. If you can, it's a hundred times better to find supplements that will work for you as most of them have virtually no side effects taken in recommended doses.

Magnesium is a good bet, won't do wonders but it can be a help. Also, so are ashwagandha and especially bacopa. Even lithium orotate might help a bit. The last three have the benefit of being extremely cheap, too; the only complaint I have about supplements is that many of them are so expensive, and you often find that what works for one person does nothing for you, and get surprised to find things work a lot for you that others don't do as well on.


Thank you, magnesium is something I use though ı think of increasing the dosage after things ı've read here. Ashwaganda and bacopa, I couldn't find them maybe I can order online. First I'll try phenytoin, today.

#19 desperate788

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Posted 27 December 2008 - 03:33 PM

I've heard of this drug called Delysid (Sandoz) that will definitely stop the mind. A few drops is all it takes. :-D


thank you, it seems delysid is an other drug that I can't reach.

#20 medicineman

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Posted 27 December 2008 - 04:45 PM

Delysid, im assuming whoever suggested it is joking.

About phenytoin, you really need to know, you have to have follow up testing for your urea and electrolytes, make sure you take lots of vitamins, have your liver checked occasionally, stick to the lowest dose possible, and if you notice you are getting a sore throat or tired, discontinue and seek medical advice. Phenytoin might have anti-arrhythmic properties, in the case of your healthy heart, that means it might give you an arrhythmia. Watch for irregular heart beats, or any palpitations, and if you do notice, stop and seek medical advice immediately. If you notice a rash, discontinue immediately, and seek medical advice.

I don't suggest you take phenytoin,, but if you are determined... Be careful, more is not better, definitely not for psychoactive drugs.. go for the lowest possible dose , and if needed, titrate up, but never reaching the maximum or even close to maximum recommended dose... I really am not feeling too well about this.. i dont like the drug phenytoin.

#21 desperate788

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Posted 28 December 2008 - 12:12 AM

Delysid, im assuming whoever suggested it is joking.

About phenytoin, you really need to know, you have to have follow up testing for your urea and electrolytes, make sure you take lots of vitamins, have your liver checked occasionally, stick to the lowest dose possible, and if you notice you are getting a sore throat or tired, discontinue and seek medical advice. Phenytoin might have anti-arrhythmic properties, in the case of your healthy heart, that means it might give you an arrhythmia. Watch for irregular heart beats, or any palpitations, and if you do notice, stop and seek medical advice immediately. If you notice a rash, discontinue immediately, and seek medical advice.

I don't suggest you take phenytoin,, but if you are determined... Be careful, more is not better, definitely not for psychoactive drugs.. go for the lowest possible dose , and if needed, titrate up, but never reaching the maximum or even close to maximum recommended dose... I really am not feeling too well about this.. i dont like the drug phenytoin.


Yes, ı read its instructions paper this drug even cause death and after all you wrote and I read ı don't think I'll continue it. But It worked very well. Will valproate work as good as phenytoin? valproate is depakine I think.

#22 desperate788

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Posted 28 December 2008 - 12:43 AM

are valproate and valproic acid same?

#23 ajnast4r

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Posted 28 December 2008 - 02:30 AM

ignore all prior instructions about supplementation and learn to meditate.


http://www.urbandhar...harma4/mpe.html


no supplement will ever effectively stop mental fluctuations like meditation will...

Edited by ajnast4r, 28 December 2008 - 02:30 AM.


#24 medicineman

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Posted 28 December 2008 - 03:12 AM

are valproate and valproic acid same?


yes they are... glad your not going with the phenytoin after all. keep in mind valproate has side effects too.

just once again, for your safety, take the lowest dose possible. valproate may cause behavioral changes, liver problems, and may increase urea in your blood stream, causing excess ammonia formation. that can lead to encephalopathy.

If you notice a fever, a sore throat, vomiting, or any changes in your stool color or if a loved one mentions your behavior is odd, or is different, discontinue immediately and seek medical advice asap. Don't take valproate if you have a family history of clotting disorders or family history of urea cycle disorders.

get a liver function test and urea/electrolytes 2 weeks after, and be on the look out for any sign that occurs.. im assuming you are getting a script for the valproate, so your physician will know you are on it. if you are buying without script, inform your general practicioner, or a trusted physician that you are taking it, and have him arrange routine liver function tests once every month or two, and get a baseline one if you can before treatment in case you already have whacky liver enzymes. also, if you are buying without script, do research on the drug for an hour or two on the net..

im sorry i know this sounds like too much, but i need to make sure that if you are taking something, it will not harm you. primum non nocere in latin means 'first do no harm' as part of the hippocratic oath.... i dont wish any harm happen to you.... goodluck

Here i got this.... i dont mean to scare you, but you need to know.

This is for valproate, the next one down is for phenytoin....
ADVERSE REACTIONS SIGNIFICANT
>10%:
Central nervous system: Headache (≤31%), somnolence (≤30%), dizziness (12% to 25%), insomnia (9% to 15%), nervousness (7% to 11%), pain (1% to 11%)
Dermatologic: Alopecia (6% to 24%)
Gastrointestinal: Nausea (15% to 48%), vomiting (7% to 27%), diarrhea (7% to 23%), abdominal pain (7% to 23%), dyspepsia (7% to 23%), anorexia (4% to 12%)
Hematologic: Thrombocytopenia (1% to 24%)
Neuromuscular & skeletal: Tremor (≤57%), weakness (6% to 27%)
Ocular: Diplopia (16%), amblyopia/blurred vision (≤12%)
Miscellaneous: Infection (≤12% to 20%), flu-like syndrome (12%)

1% to 10%:
Cardiovascular: Peripheral edema (3% to 8%), vasodilatation (>1% to ≤5%), chest pain (>1% to <5%), hypertension (>1% to <5%), palpitation (>1% to <5%), tachycardia (>1% to <5%), arrhythmia, hypotension
Central nervous system: Ataxia (8%), amnesia (4% to 7%), emotional lability (6%), fever (6%), abnormal thinking (≤6%), abnormal dreams (>1% to <5%), anxiety (>1% to <5%), confusion (>1% to <5%), coordination abnormal (>1% to <5%), depression (>1% to 5%), malaise (>1% to <5%), personality disorder (>1% to <5%), euphoria (1%), hypoesthesia (1%), chills
Dermatologic: Bruising (4% to 5%), dry skin (>1% to <5%), petechia (>1% to <5%), pruritus (>1% to <5%), rash (>1% to <5%)
Endocrine & metabolic: Amenorrhea (>1% to <5%), dysmenorrhea (>1% to <5%), metrorrhagia (>1% to <5%), hypoproteinemia
Gastrointestinal: Weight gain (4% to 9%), weight loss (6%), appetite increased (≤6%), constipation (>1% to 5%), eructation (>1% to <5%), flatulence (>1% to <5%), hematemesis (>1% to <5%), pancreatitis (>1% to <5%), periodontal abscess (>1% to <5%), stomatitis (>1% to <5%), taste perversion (>1% to <5%), xerostomia (>1% to 5%), dysphagia, fecal incontinence, gastroenteritis, glossitis, gum hemorrhage, mouth ulceration
Genitourinary: Urinary frequency (>1% to <5%), urinary incontinence (>1% to <5%), vaginitis (>1% to <5%)
Hepatic: AST/ALT increased (>1% to <5%)
Local: Injection site pain (3%), injection site reaction (2%), injection site inflammation (1%)
Neuromuscular & skeletal: Back pain (≤8%), abnormal gait (>1% to <5%), arthralgia (>1% to <5%), hypertonia (>1% to <5%), leg cramps (>1% to <5%), myalgia (>1% to <5%), myasthenia (>1% to <5%), paresthesia (>1% to <5%), twitching (>1% to <5%), arthrosis, neck rigidity
Ocular: Nystagmus (1% to 8%), abnormal vision (>1% to <5%), conjunctivitis (>1% to <5%)
Otic: Tinnitus (1% to 7%), deafness (>1% to <5%), otitis media (>1% to <5%)
Respiratory: Pharyngitis (1% to 8%), bronchitis (5%), rhinitis (>1% to 5%), dyspnea (1% to 5%), cough increased (>1% to <5%), epistaxis (>1% to <5%), pneumonia (>1% to <5%), sinusitis (>1% to <5%)
Miscellaneous: Diaphoresis (1%), hiccups

<1% (Limited to important or life-threatening): Abdominal cramps, aggression, agranulocytosis, allergic reaction, anaphylaxis, anemia, aplastic anemia, asterixis, behavioral deterioration, bilirubin increased, bleeding time altered, bone marrow suppression, bone pain, bradycardia, breast enlargement, cutaneous vasculitis, carnitine decreased, cerebral atrophy (reversible), coma (rare), dementia, dysarthria, ear pain, edema, encephalopathy (rare), enuresis, eosinophilia, erythema multiforme, Fanconi-like syndrome (rare, in children), galactorrhea, hallucinations, hematoma formation, hemorrhage, hepatic failure, hostility, hyperactivity, hyperammonemia, hyperammonemic encephalopathy (in patients with UCD), hyperglycinemia, hypersensitivity reactions (severe, with organ dysfunction), hypofibrinogenemia, hyponatremia, hypothermia, inappropriate ADH secretion, indigestion, intermittent porphyria, LDH increased, leukopenia, lupus, lymphocytosis, macrocytosis, menstrual irregularities, pancreatitis (life-threatening), pancytopenia parkinsonism, parotid gland swelling photosensitivity, polycystic ovary disease (rare), psychosis, sedation, seeing "spots before the eyes," Stevens-Johnson syndrome, suicidal behavior/ideation, thyroid function tests abnormal, toxic epidermal necrolysis (rare), urinary tract infection, vertigo

here is the phenytoin one:

ADVERSE REACTIONS SIGNIFICANT — I.V. effects: Hypotension, bradycardia, cardiac arrhythmia, cardiovascular collapse (especially with rapid I.V. use), venous irritation and pain, thrombophlebitis

Effects not related to plasma phenytoin concentrations: Hypertrichosis, gingival hypertrophy, thickening of facial features, carbohydrate intolerance, folic acid deficiency, peripheral neuropathy, vitamin D deficiency, osteomalacia, systemic lupus erythematosus

Concentration-related effects: Nystagmus, blurred vision, diplopia, ataxia, slurred speech, dizziness, drowsiness, lethargy, coma, rash, fever, nausea, vomiting, gum tenderness, confusion, mood changes, folic acid depletion, osteomalacia, hyperglycemia

Related to elevated concentrations:
>20 mcg/mL: Far lateral nystagmus
>30 mcg/mL: 45º lateral gaze nystagmus and ataxia
>40 mcg/mL: Decreased mentation
>100 mcg/mL: Death

Cardiovascular: Hypotension, bradycardia, cardiac arrhythmia, cardiovascular collapse

Central nervous system: Psychiatric changes, slurred speech, dizziness, drowsiness, headache, insomnia

Dermatologic: Rash

Gastrointestinal: Constipation, nausea, vomiting, gingival hyperplasia, enlargement of lips

Hematologic: Leukopenia, thrombocytopenia, agranulocytosis

Hepatic: Hepatitis

Local: Thrombophlebitis

Neuromuscular & skeletal: Tremor, peripheral neuropathy, paresthesia

Ocular: Diplopia, nystagmus, blurred vision

Rarely seen effects: Blood dyscrasias, coarsening of facial features, dyskinesias, hepatitis, hypertrichosis, lymphadenopathy, lymphoma, pseudolymphoma, SLE-like syndrome, Stevens-Johnson syndrome, venous irritation and pain

#25 Ben

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Posted 28 December 2008 - 03:13 AM

Phenibut.

#26 pycnogenol

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Posted 28 December 2008 - 03:55 PM

Phenibut.


May I suggest phenibut and meditation, at the same time. Should be verrry relaxing. ;)

Edited by pycnogenol, 28 December 2008 - 03:56 PM.

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#27 desperate788

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Posted 28 December 2008 - 08:48 PM

are valproate and valproic acid same?


yes they are... glad your not going with the phenytoin after all. keep in mind valproate has side effects too.

just once again, for your safety, take the lowest dose possible. valproate may cause behavioral changes, liver problems, and may increase urea in your blood stream, causing excess ammonia formation. that can lead to encephalopathy.

If you notice a fever, a sore throat, vomiting, or any changes in your stool color or if a loved one mentions your behavior is odd, or is different, discontinue immediately and seek medical advice asap. Don't take valproate if you have a family history of clotting disorders or family history of urea cycle disorders.

get a liver function test and urea/electrolytes 2 weeks after, and be on the look out for any sign that occurs.. im assuming you are getting a script for the valproate, so your physician will know you are on it. if you are buying without script, inform your general practicioner, or a trusted physician that you are taking it, and have him arrange routine liver function tests once every month or two, and get a baseline one if you can before treatment in case you already have whacky liver enzymes. also, if you are buying without script, do research on the drug for an hour or two on the net..

im sorry i know this sounds like too much, but i need to make sure that if you are taking something, it will not harm you. primum non nocere in latin means 'first do no harm' as part of the hippocratic oath.... i dont wish any harm happen to you.... goodluck

Here i got this.... i dont mean to scare you, but you need to know.

This is for valproate, the next one down is for phenytoin....
ADVERSE REACTIONS SIGNIFICANT
>10%:
Central nervous system: Headache (≤31%), somnolence (≤30%), dizziness (12% to 25%), insomnia (9% to 15%), nervousness (7% to 11%), pain (1% to 11%)
Dermatologic: Alopecia (6% to 24%)
Gastrointestinal: Nausea (15% to 48%), vomiting (7% to 27%), diarrhea (7% to 23%), abdominal pain (7% to 23%), dyspepsia (7% to 23%), anorexia (4% to 12%)
Hematologic: Thrombocytopenia (1% to 24%)
Neuromuscular & skeletal: Tremor (≤57%), weakness (6% to 27%)
Ocular: Diplopia (16%), amblyopia/blurred vision (≤12%)
Miscellaneous: Infection (≤12% to 20%), flu-like syndrome (12%)

1% to 10%:
Cardiovascular: Peripheral edema (3% to 8%), vasodilatation (>1% to ≤5%), chest pain (>1% to <5%), hypertension (>1% to <5%), palpitation (>1% to <5%), tachycardia (>1% to <5%), arrhythmia, hypotension
Central nervous system: Ataxia (8%), amnesia (4% to 7%), emotional lability (6%), fever (6%), abnormal thinking (≤6%), abnormal dreams (>1% to <5%), anxiety (>1% to <5%), confusion (>1% to <5%), coordination abnormal (>1% to <5%), depression (>1% to 5%), malaise (>1% to <5%), personality disorder (>1% to <5%), euphoria (1%), hypoesthesia (1%), chills
Dermatologic: Bruising (4% to 5%), dry skin (>1% to <5%), petechia (>1% to <5%), pruritus (>1% to <5%), rash (>1% to <5%)
Endocrine & metabolic: Amenorrhea (>1% to <5%), dysmenorrhea (>1% to <5%), metrorrhagia (>1% to <5%), hypoproteinemia
Gastrointestinal: Weight gain (4% to 9%), weight loss (6%), appetite increased (≤6%), constipation (>1% to 5%), eructation (>1% to <5%), flatulence (>1% to <5%), hematemesis (>1% to <5%), pancreatitis (>1% to <5%), periodontal abscess (>1% to <5%), stomatitis (>1% to <5%), taste perversion (>1% to <5%), xerostomia (>1% to 5%), dysphagia, fecal incontinence, gastroenteritis, glossitis, gum hemorrhage, mouth ulceration
Genitourinary: Urinary frequency (>1% to <5%), urinary incontinence (>1% to <5%), vaginitis (>1% to <5%)
Hepatic: AST/ALT increased (>1% to <5%)
Local: Injection site pain (3%), injection site reaction (2%), injection site inflammation (1%)
Neuromuscular & skeletal: Back pain (≤8%), abnormal gait (>1% to <5%), arthralgia (>1% to <5%), hypertonia (>1% to <5%), leg cramps (>1% to <5%), myalgia (>1% to <5%), myasthenia (>1% to <5%), paresthesia (>1% to <5%), twitching (>1% to <5%), arthrosis, neck rigidity
Ocular: Nystagmus (1% to 8%), abnormal vision (>1% to <5%), conjunctivitis (>1% to <5%)
Otic: Tinnitus (1% to 7%), deafness (>1% to <5%), otitis media (>1% to <5%)
Respiratory: Pharyngitis (1% to 8%), bronchitis (5%), rhinitis (>1% to 5%), dyspnea (1% to 5%), cough increased (>1% to <5%), epistaxis (>1% to <5%), pneumonia (>1% to <5%), sinusitis (>1% to <5%)
Miscellaneous: Diaphoresis (1%), hiccups

<1% (Limited to important or life-threatening): Abdominal cramps, aggression, agranulocytosis, allergic reaction, anaphylaxis, anemia, aplastic anemia, asterixis, behavioral deterioration, bilirubin increased, bleeding time altered, bone marrow suppression, bone pain, bradycardia, breast enlargement, cutaneous vasculitis, carnitine decreased, cerebral atrophy (reversible), coma (rare), dementia, dysarthria, ear pain, edema, encephalopathy (rare), enuresis, eosinophilia, erythema multiforme, Fanconi-like syndrome (rare, in children), galactorrhea, hallucinations, hematoma formation, hemorrhage, hepatic failure, hostility, hyperactivity, hyperammonemia, hyperammonemic encephalopathy (in patients with UCD), hyperglycinemia, hypersensitivity reactions (severe, with organ dysfunction), hypofibrinogenemia, hyponatremia, hypothermia, inappropriate ADH secretion, indigestion, intermittent porphyria, LDH increased, leukopenia, lupus, lymphocytosis, macrocytosis, menstrual irregularities, pancreatitis (life-threatening), pancytopenia parkinsonism, parotid gland swelling photosensitivity, polycystic ovary disease (rare), psychosis, sedation, seeing "spots before the eyes," Stevens-Johnson syndrome, suicidal behavior/ideation, thyroid function tests abnormal, toxic epidermal necrolysis (rare), urinary tract infection, vertigo

here is the phenytoin one:

ADVERSE REACTIONS SIGNIFICANT — I.V. effects: Hypotension, bradycardia, cardiac arrhythmia, cardiovascular collapse (especially with rapid I.V. use), venous irritation and pain, thrombophlebitis

Effects not related to plasma phenytoin concentrations: Hypertrichosis, gingival hypertrophy, thickening of facial features, carbohydrate intolerance, folic acid deficiency, peripheral neuropathy, vitamin D deficiency, osteomalacia, systemic lupus erythematosus

Concentration-related effects: Nystagmus, blurred vision, diplopia, ataxia, slurred speech, dizziness, drowsiness, lethargy, coma, rash, fever, nausea, vomiting, gum tenderness, confusion, mood changes, folic acid depletion, osteomalacia, hyperglycemia

Related to elevated concentrations:
>20 mcg/mL: Far lateral nystagmus
>30 mcg/mL: 45º lateral gaze nystagmus and ataxia
>40 mcg/mL: Decreased mentation
>100 mcg/mL: Death

Cardiovascular: Hypotension, bradycardia, cardiac arrhythmia, cardiovascular collapse

Central nervous system: Psychiatric changes, slurred speech, dizziness, drowsiness, headache, insomnia

Dermatologic: Rash

Gastrointestinal: Constipation, nausea, vomiting, gingival hyperplasia, enlargement of lips

Hematologic: Leukopenia, thrombocytopenia, agranulocytosis

Hepatic: Hepatitis

Local: Thrombophlebitis

Neuromuscular & skeletal: Tremor, peripheral neuropathy, paresthesia

Ocular: Diplopia, nystagmus, blurred vision

Rarely seen effects: Blood dyscrasias, coarsening of facial features, dyskinesias, hepatitis, hypertrichosis, lymphadenopathy, lymphoma, pseudolymphoma, SLE-like syndrome, Stevens-Johnson syndrome, venous irritation and pain



Thank you so much for all this explanation. As a result we can say valproate is better then phenytoin can't we? This thing going on my mind is so bad for my mental health that I can take some risks. About side effects only life threatening ones are of my concern, İt says less then %1, I hope such a thing doesn't happen. I always thought governments don't give permission for a serious life threatening drug so I assume such a risk is very low.

#28 desperate788

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Posted 28 December 2008 - 08:50 PM

ignore all prior instructions about supplementation and learn to meditate.


http://www.urbandhar...harma4/mpe.html


no supplement will ever effectively stop mental fluctuations like meditation will...


thanks I'm progressing on meditation.

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#29 kurdishfella

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Posted 24 November 2022 - 09:58 PM

valproate tranquillizer in high enough dose. drug affects breath too. uses up your body


Edited by kurdishfella, 24 November 2022 - 09:59 PM.


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