Who is using Tween 80 Resveratrol supplement.
#31
Posted 08 February 2009 - 04:24 PM
Joe
#32
Posted 09 February 2009 - 01:06 AM
Edited by 2tender, 09 February 2009 - 01:07 AM.
#33
Posted 15 February 2009 - 02:09 AM
Im taking Tween 80 one day then longevinex the next at once daily dosing, its an economical and reasonable approach, if I feel sides I skip a day .I dont think dosing more than once a day is needed but dosing regularly is. Stay with it and see how you feel, regular exercise helps release endogenous hormones.
So is that 100mg longevinex one day and one Tween-80 the next?
at 180lbs, I've been taking 200-300mg longevinex for a year and reported some of my positive stamina experiences on the "optimal dose" thread. (Ive known two who stopped after 1)upset stomach 2)"felt strange" [I felt strangeness around day 7 but lasted a few hours, and I was at 500mg the first week] but the rest seem to either like it and have no problem) I'm thinking of getting Tween 80 as well, so I'm curious what dose or combination people are taking.
I'm not sure either companies micronized methods improve things, but I don't know.
By the way, others have mentioned skin, and I noticed around the six month mark that my skin was very smooth. Strangely smooth, and I didn't expect this at all. My girlfriend felt my back and legs and thought it was great. Still, I wondered if due to resveratrol.
Edited by Holmes, 15 February 2009 - 02:19 AM.
#34
Posted 15 February 2009 - 01:03 PM
Edited by 2tender, 15 February 2009 - 01:14 PM.
#35
Posted 15 February 2009 - 02:12 PM
I have read where some people have experienced weight loss while on res and others have not. I would posit that perhaps this is due to the effects res may have on insulin sensitivity -- the less insulin your body requires, the more likely you are to lose weight since insulin is a fat storage hormone -- but this is just my theory.
Hope this helps, but I have been able to actually document the effects res has on my lower insulin needs and glucose readings. I am surprised more diabetics have not reported similar documented effects on this forum.
#36
Posted 15 February 2009 - 02:19 PM
I have read where some people have experienced weight loss while on res and others have not. I would posit that perhaps this is due to the effects res may have on insulin sensitivity -- the less insulin your body requires, the more likely you are to lose weight since insulin is a fat storage hormone -- but this is just my theory.
Hope this helps, but I have been able to actually document the effects res has on my lower insulin needs and glucose readings. I am surprised more diabetics have not reported similar documented effects on this forum.
#37
Posted 18 February 2009 - 02:07 PM
#38
Posted 19 February 2009 - 02:56 PM
I have been hearing that alot lately.
It appears that the Micronized resveratrol & Tween 80 in our liquid capsules are easier to digest over the dry powder capsules.
I suppose that is an additional benefit I overlooked.
A
#39
Posted 19 February 2009 - 04:19 PM
I was waiting for some extra time to pass before making the same judgement, but I think 2 weeks on Tween80 is a reasonable marker for me, since in my present state I couldn't have gone 2 weeks on powder alone (and I suspect my sensitivity was caused or hastened by taking rsv powder mixed with alcohol for a number of months). It looks like Tween80 will allow me to keep going with rsv at 500 mg per day, though the glory days of downing 2 or 3 grams of powder at a time appear to be over...Hi 2tender,
I have been hearing that alot lately.
It appears that the Micronized resveratrol & Tween 80 in our liquid capsules are easier to digest over the dry powder capsules.
I suppose that is an additional benefit I overlooked.
A
#40
Posted 19 February 2009 - 11:28 PM
#41
Posted 21 February 2009 - 12:37 AM
I'm hoping to get one clue about the dose being received if I get the same benefits for my "tolio" [tm maxwatt] that maxwatt did. If I do, I'll assume it's at least around 10x. If I don't, I'll try adding 500 mg. of 99% regular, non-micronized resveratrol and wait for three months, then another, and see if that helps.
The question is: does the AUC have anything to do with the impact of resveratrol? Or is it all about the peak level?
#42
Posted 07 March 2009 - 03:03 PM
Ihave been on the tween 80 product for 5 weeks, after 3 weeks my skin is smoother and softer, also i am 57 and age related keratosis on my back and sun damage on face is fading. I saw my dermatologist Dec 08 and 3 days ago confirms this change. I have done nothing slse different except the resveratrol so it likely is the cause. This happened in Maine winter which tends to dry out skin.
I have seen improvement in exercise, especially recovery time but this could be due to just better shape since last month. I had no muscle or tendon or stomach problems as reported by some posters.
Have others seen similiar skin changes?
xraydave
#43
Posted 07 March 2009 - 05:55 PM
I don't know about peak dose, but when I tried to estimate the AUC compared to a regular powder dose of 250 mg., based on the graphs, it was roughly 13x as much. However, the graphs provided referred to resveratrol micronized to an average size of 1 micron. But the product-that-shall-not-be-named uses resveratrol micronized to an average size of 1.5 microns. So that should definitely lower the absorption ratio, but I'm not sure by how much. I assume it would produce similar percentage reduction in the peak level, which should be factored into the earlier estimate.
I'm hoping to get one clue about the dose being received if I get the same benefits for my "tolio" [tm maxwatt] that maxwatt did. If I do, I'll assume it's at least around 10x. If I don't, I'll try adding 500 mg. of 99% regular, non-micronized resveratrol and wait for three months, then another, and see if that helps.
The question is: does the AUC have anything to do with the impact of resveratrol? Or is it all about the peak level?
Just thought to throw out some ideas since no one has replied to this yet.
Totally just my opinion, but I think AUC is more important to resveratrol function than peak concentration. If resveratrol is activating Nampt (or even if Sirt1 directly, as unlikely as that seems now), then the longer it keeps Nampt active, the higher the chance you'll get a nice positive feedback loop, where Nampt activity activates Sirt1 which activates AMPK which in turn activates more Nampt activity. The longer the exposure to the exogenous (resveratrol) activation signal, the longer this pathway, and all subsequently activated dependent pathways (i.e. PGC-1alpha), will be active. Because this takes time, even a sudden, intense burst of Nampt activity (high peak concentration) may not last long enough for the feedback to set up.
Now, you still need an AUC that's above the critical concentration for resveratrol to activate it's effectors, so it is not an either/or sort of deal. You want the highest peak and AUC. But if you have to sacrifice some peak for more AUC, I would do so. This also is in line with the way resveratrol is given to animals in the in vivo studies: in their food, eaten slowly throughout a day, which would most likely give a large AUC and small peak.
On the other hand, some other resveratrol effects, such as anti-tumor activity, may need a high peak concentration -- as once those apoptotic signals are started, it's a done deal, and constant stimulation is not necessary, while at the same time they have a very high threshold for activation in the first place.
Edited by geddarkstorm, 07 March 2009 - 05:58 PM.
#44
Posted 10 March 2009 - 05:18 AM
#45
Posted 05 April 2009 - 10:13 PM
#46
Posted 05 April 2009 - 10:39 PM
#47
Posted 05 April 2009 - 10:40 PM
I was going to buy this product until I looked up side effects of tween 80. I found an article that said it's toxic and causes infertility. Is this info worth considering or sensationalism?
Sensationalism, as the mouse studies state you need to inject mice with polysorbate 80, as orally taken it does none of these things.
As a side note, no supplement should be injected. They are not made for this purpose. If you want to know of other supplements that contain tween 80, check out many of the CoQ10 supplements. Although many CoQ10 supplements have this for the same purposes the tween 80 resveratrol supplement has it, no one appears to complain about it, and consumer labs passes all of the CoQ10 supplements with tween 80, with flying colors.
So unless you open up a bunch of capsules, put the emulsion liquid into a syringe, and inject it directly into a vein... you should have no issues just like the many CoQ10 supplements available everywhere...
Cheers
A
Edited by Anthony_Loera, 05 April 2009 - 10:44 PM.
#48
Posted 05 April 2009 - 11:42 PM
#49
Posted 05 April 2009 - 11:45 PM
... I am primarily interested in any fasting glucose effects.
And what have you noticed personally in regard to this?
#50
Posted 06 April 2009 - 04:18 AM
... I am primarily interested in any fasting glucose effects.
And what have you noticed personally in regard to this?
Nothing statistically significant. But I didn't expect such.
#51
Posted 21 April 2009 - 11:23 AM
am i the only person who thinks a sustained release resveratrol might be a more healthy product rather than a massive 1-2 hr spike of resv?
or am i miss understanding resveratrol and how it functions innately?
#52
Posted 21 April 2009 - 12:54 PM
tried the nitro 250 w/ tween yesterday. stuff is crazy good/strong. lot of endurance/energy.
am i the only person who thinks a sustained release resveratrol might be a more healthy product rather than a massive 1-2 hr spike of resv?
or am i miss understanding resveratrol and how it functions innately?
Res increases one's NAD/NADH ratio, which is associated with longevity and an effect shown by other putative CR mimetics.
Recently I posted about a study showing NAD to vary in a circadian rhythm, and disturbing the cycle had deleterious effects in rodents. (Part of an as-yet-unpublished PhD thesis, read at a paper at a conference in Brighton England.) Consequently I take my resveratrol only in the morning, and find I have better results so far. Taking resveratrol continuously through the day is not, IMO, a good idea. I also think a two day break once a week is helpful. I also believe, based on my experience and that of people I have been working with, that the older one is, higher the dose needed, that the optimal dose for a given effect decreases with time, and that too much for your needs can lead to tendinitis-like symptoms. Also genetics is a factor; Asians do not in general sulfonate as efficiently as Europeans, and so attain a higher serum level for a given dose. Luteolin inhibits sulfonation 10 times better than quercetin, some have used these to increase serum levels, but they may have effects of their own. I have quite a bit of luteolin on hand from a batch I supplied to a university researcher; if anyone has a legitimate need for research purposes PM me.
Probably the highest peak serum level attainable is best; I'd expect once genes are switched on they remain so for a period of time, or their effects linger. You'd want the highest concentration to activate the most genes in the most tissue possible. The Tween80 cocktail likely attains the highest peak per gram of anything we have been able to try so far. Homebrews with other surfactants such as lecithin are a pain to make properly. Stirring for an hour is inconvenient. HPMC gives similar effects to Tween80, some of us are still using it, though mixing is less convenient than a capsule. Anthony, I salute you.
#53
Posted 21 April 2009 - 10:47 PM
#54
Posted 22 April 2009 - 12:47 AM
... I dont think the dose needs to be increased over a period of time, that has not been my experience so far, the 250 has been adequate (and the TD Im using on occasion).
Are you taking 250mg of quercetin at the same time?
#55
Posted 22 April 2009 - 08:38 AM
So, are people taking resveratrol in the morning?
It seems to lower my energy levels if I take it upon awakening, - I'd have to drink a pot of coffee to smooth this out.
#56
Posted 22 April 2009 - 08:43 AM
#57
Posted 22 April 2009 - 10:52 AM
... I dont think the dose needs to be increased over a period of time, that has not been my experience so far, the 250 has been adequate (and the TD Im using on occasion).
Are you taking 250mg of quercetin at the same time?
No, Im not. Comments regarding use of Quercitin?
#58
Posted 22 April 2009 - 10:57 AM
>>> I concur with the majority of Maxwalts observations. It is best to take it within 3 hours of awakening <<<
So, are people taking resveratrol in the morning?
It seems to lower my energy levels if I take it upon awakening, - I'd have to drink a pot of coffee to smooth this out.
Thats exactly when I take mine, after 3 cups of instant coffee. What type of Res. are you taking? It could a reaction from other supplements you are taking or maybe it just works better for you at night. I initially took it at night but it interfered with sleep.
Edited by 2tender, 22 April 2009 - 10:58 AM.
#59
Posted 22 April 2009 - 11:48 PM
Actually, this reminds me. When I read through some of the long 1-3 year threads, my memory is that Anthony said he was taking 2 grams of rsv per day in pill form (sorry if I have it wrong). But I haven't seen any recent updates by Anthony concerning his rsv regimen. Anthony, the biggest thing I am curious about is whether you are now using the Tween 80, and how much per day of whatever product are you currently taking?Anthony, I salute you.
#60
Posted 23 April 2009 - 03:11 AM
I am taking 2 capsules of the Nitro250... (I guess it gives you an idea of what I think of them)
...and continue to take M98 in protein shakes as the shakes are yummy.
Cheers
A
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