There are vast numbers of likeable genes I am thinking about the idea of speeddate.com combining forces with a gene screen company to create a voluntary eugenics opportunity
The idea is that if there are say dozens of genes (I know there is much to this: constellations, SNPs, cytokines, prechemical pathways) when one parent has 3 favorable genes that contribute to a trait n the other contributor has 3 complementary genes the child does particularly well
I'm kind of looking at kindness happiness cleverness beauty calmness as areas I favor genetically
Kindness genes
genetic variants for both AVPR1A, encoding the primary receptor of vasopressin in brain, and the oxytocin receptor, OXTR, in amygdala regulation and activation
AVPR1a goes with altruism as well as prosocial behaviors individual differences in allocation of funds in the dictator game, a laboratory game of pure altruism, is predicted by length of the AVPR1a RS3 promoter-region repeat echoing the mechanism of this hormone's action in the vole model of affiliative behaviours and facilitation of positive group interactions
Happiness Genes
targeting the s type of the 5-HTTLPR gene because if children are conceived with the long version of the gene they are about half as anxious, half as obsessive, generally a third less neurotic, generally slightly more trusting, plus more directed towards their own values
Heritability of life satisfaction in adults: a twin-family study
SWB and perceived health was to a high extent influenced by the same genes (r(g)=.72 and.82 for males and females, respectively
Cleverness Genes
CHRM2 the DHA lipid production pathway known as Sprecher's shunt, IGF2R cumulatively give 34 points of higher IQ
CHRM2 gene gives 15 or 20 points IQ
My idea is that
DHA at breastfeeding gives ten points higher IQ; paper cites chemical effect as well as 1.08 iq points per month of breastfeeding 10 month measure gives 10 points thus Combining this paper with the idea of regulating the human genes that make DHA on the lipid pathway Sprecher's shunt gives a 10 plus point IQ raise gene area
also the constellation of tallness genes correlates with IQ I think I've read the named genes statistically significant effects of correlated genes and nonshared environments were also found (respectively 35% and 6% of the phenotypic correlation).
New Scientist http://www.newscient...-the-genes.html has a graph showing the heritability of myelin quality at different brain regions from 100 pt at corpus callosum which goes with hemispgeric communication n more than 4/5 at parietal lobe where temporal goes with n parietal goes with logic n Math ability
also volume of the brain's grey matter, made up of "processor" cells, is heritable and correlates with certain elements of IQ (Nature Neuroscience, DOI: 10.1038/nn758). The amount of white matter, which provides the connections between these processors, has since been shown to be heritable
Beauty Genes
There are many approaches to beauty I favor phenotypic choice That said I tend to gaze at tall women with pale skin n large breasts Tallness genes Seven SNPs in or near the genes HHIP, DLEU7, UQCC, SF3B4/SV2A, LCORL, and HIST1H1D associated with PHV1 and five SNPs in or near SOCS2, SF3B4/SV2A, C17orf67, CABLES1, and DOT1L with PHV2 (p<0.05). as well as (ZNP) 510 and ZNP782, achieved strong signals for association with stature with P values ranging from 9.71 x 10(-5) to 3.11 x 10(-6).
paleness has a variety of genetic determinants as does eye color effects between HERC2 and OCA2 may be responsible for blue eye colour HERC2 rs12913832 with eye colour and showed that this SNP is also significantly associated with skin and hair colouration MC1R alleles (RHC) have been associated with red hair, fair skin OCA2 relates to hair color keratinocytes play a significant role in skin color determination by producing cytokines involved in melanogenesis. Thus, we hypothesized that the downregulated expression of keratinocyte- or fibroblast-derived melanogenic cytokines may also be responsible for the decreased function of palmoplantar (PP) melanocytes the suppressive effects of dickkopf 1 on melanogenic function in epidermal melanocytes. Immunohistochemistry revealed that the number of tyrosinase, S100alpha, c-KIT, endothelin B receptor (ETBR), SOX10, and microphthalmia-associated transcription factor (MITF) immuno-positive melanocytes is significantly reduced in PP epidermis SCF, c-KIT, and MITF-M proteins was significantly decreased in PP skin. These findings suggest the possibility that downregulation of ET-1/SCF/receptor linkages is also associated with the decreased function of melanocytes in PP skin
I like the idea of people choosing their phenotype at any time
Breast size is associated with estrogen single nucleotide polymorphism rs2470152 in intron 1 of the CYP19 gene, which codes for aromatase, responsible for the final step of the biosynthesis of E2 and E1, to be most significantly associated with serum E2 levels Breast mammography density is gene associated with IGF IGF-I rs1520220 causes higher tissue:fat ration density or firmness rs361072 SNP had less tissue:fat density or higher softness Health outcomes may also be associated with these genes
Note that width:height ratio is adjustable with tallness genes regarding mass variant in the FTO gene, rs9939609, associates with body mass index (BMI) thus skinny FTO variant also leptin variants affect BMI There is also protective effect of the ER22/23EK polymorphism against an excessive weight gain during pregnancy
Copy number variations of particular genes are published as affecting BMI CNV at 10q11.22 (from 46.36 Mb to 46.56 Mb) was associated with BMI
Note there is a California fertility clinic with an attractiveness IVF genetics program Their gene list applies as well
Calmness Genes
5-HTTLPR which predicts positive affect Persons with the long version (blue) are about half as anxious, half as obsessive, generally a third less neurotic, generally slightly more trusting, plus more directed towards their own values They have fewer psychosomatic illnesses BUT they have noticeably less less "interpersonal sensitivity"
For overt aggressive impulsivity nominal significance was shown for 6 SNPs from BDNF, DRD4, HTR1E, PNMT, and TPH2 genes Also aggressive behavioral impulsivity with a DRD4 variant (exon 3: 3 repeats) are also described
Knowing all of this as well as rather more a person could speed date online or live with a prechosen party group with the purposed idea of knowing that if there were children as a result of dating they would be particularly kind happy clever beautiful calm people
Which is beneficial as half or more of couples divorce creating stress It is possible that children with prearranged genomes may resist turbulent environments to become wonderful people anyway
Edited by treonsverdery, 11 March 2009 - 10:25 PM.
