That must be Anthony's post #24 in this thread. Does anyone have a citation on that, or the author's names?
Boocock's paper found peak blood serum levels in humans of 117 ng/ml at a dose of 1 g (14 mg/kg for a 70 kg human) effectively the same as a mouse gets from a dose 400mg/kg. ( Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Boocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP, Booth TD, Crowell JA, Perloff M, Gescher AJ, Steward WP, Brenner DE., Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1246-52.
(
Of Mice, men and resveratrol) thread.
According the study Anthony turned up, the lower concentrations of RES in the study were 6.25um, 12.5um and 25um. See Page 3 under "Results" it states "we further studied the effect of relatively lower concentrations of RES (at 6.25, 12.5 and 25 uM)"
from post 24 in this thread.
http://www.imminst.o...&...st&p=333939All we need do is convert uM (micro Mols ) to ng/ms (nanograms per milliliter.) hint: the molecular weight of resveratrol is 228.25.
another hint: 117 ng/ml =117ug/l.
another hint: A mol of resveratrol weight 228.28 grams.
117*10-6g/228.28 = .5 uM. Did I do that right, Doctor? I used to whip these off in my head, but I am rusty, yet I think that the concentration Boocock found in humans from a 1 gram dose of resveratrol is 0.5uM. The lowest dose showing toxic effects from the U of Kansas study is over 10 times that, and is a concentration that cannot be attained in human blood serum from oral dosing.
If all our assumptions are correct, then Boocock's peak blood level is less than one tenth the beneficial lowest concentration in this U of Kansas study.
I have no doubt that resveratrol, like so many other things including water, has an inverted U-shaped benefit curve, with too much proving toxic. The question is where is the knee of the curve, and how can we stay in the rising slope of benefits? If too much is harmful, and too little is not beneficial, what is an optimal dosage range?
Dr. Alex: If you are going to cite papers in support of conclusions, it would be helpful to include enough data to help us determine if they are valid, and to contribute to our knowledge, rather than to obscure it.