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ECM powder for tissue regeneration


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#1 TheFountain

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Posted 27 July 2009 - 10:44 PM


Here, we present extracellular matrix (ECM) powders derived from human adipose tissue as injectable cell delivery carriers for adipose tissue engineering. We postulate that human adipose tissue may provide an ideal biomaterial because it contains large amounts of ECM components including collagen. Fresh human adipose tissue was obtained by a simple surgical operation (liposuction). After removing blood and oil components, the tissue was homogenized, centrifuged, freeze-dried, and ground to powders by milling. In an in vitro study, the human ECM powders were highly effective for promotion of cell attachment and proliferation for three-dimensional (3D) cell culture. In in vivo studies, suspensions of human ECM powders containing human adipose-derived stem cells (hASCs) were subcutaneously injected into nude mice. At eight weeks post-injection, numerous blood vessels were observed and the newly formed tissue exhibited adipogenesis with accumulated intracellular small lipid droplets. Overall, the grafts showed well-organized adipose tissue constructs without any signs of tissue necrosis, cystic spaces, or fibrosis. We believe that human ECM powders could act as efficient injectable biomaterials for tissue engineering and have great potential for meeting clinical challenges in regenerative medicine, particularly in relation to adipose tissue engineering.

http://www.ncbi.nlm....Pubmed_RVDocSum

#2 TheFountain

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Posted 16 February 2010 - 01:47 PM

I can't believe this never got any replies.

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#3 N.T.M.

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Posted 16 February 2010 - 09:16 PM

Woah!! That's amazing!! Any ideas as to when this will be available?

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#4 bobman

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Posted 28 February 2010 - 04:49 AM

I have some joint issues, and 4 surgeries at a young age (23). No prior health issues, played tons of contact sports without issue prior to my 1st injury. Thanks for the link. I'll fix the problem, I know that.

Edited by bobmann, 28 February 2010 - 04:49 AM.


#5 tunt01

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Posted 28 February 2010 - 05:57 AM

nice solution but not perfect. it'd be interesting to hear the pros and cons from the doctors/scientists that use it.

recruiting stem cells and accelerating division/growth can have its drawbacks (higher LT cancer risk?). but maybe more than worth it from a quality of life standpoint.

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#6 Fleet

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Posted 22 March 2010 - 09:33 AM

Is this the same powder they call pixie dust, that grows peoples finger tip back?

last night on CNN, I seen some army guy growing his quadriceps back, same technique I believe.
ohyeh, and some guy who lost his hand to a grenade, was given a donor hand and with the stem-cells of the donor it did not get rejected. (the donor hand movement control operates perfectly he said.)

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