NEW STUDY: Colon cancer study, Oct 27:
"3.7% control mice vs 68.7% resveratrol-treated mice free of metastasis. Oral resv at 30 mg/kg. Amzng"
Yes, that's pretty nice, but it was only a 3 week experiment. Still, it's a good result with a reasonable dose.
Here's the full abstract:
Mol Nutr Food Res. 2009 Oct 27. [Epub ahead of print]
Oral administration of resveratrol in suppression of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells.
Weng YL, Liao HF, Li AF, Chang JC, Chiou RY.
Department of Food Science, National Chiayi University, Chaiyi, Taiwan.
Anti-cancer activities of resveratrol (3,4',5-trihydroxylstilbene) have attracted extensive research attention. Suppression of pulmonary metastasis of BALB/c mice challenged with CT26 colorectal adenocarcinoma cells achieved by oral administration of resveratrol was assessed in three separate experiments. Each mouse was challenged by tail vein injection with CT26 cells. Prior to challenge, 8-wk-old mice were fed with a basal diet and orally administered with resveratrol (30 mg/kg/2 days) eight or twelve times. After challenge, oral administration of resveratrol was continued until mice were sacrificed on day 20. As integrated from three experiments, 3.7% of the control mice (n=27) and 68.7% of the resveratrol-treated mice (n=26) exhibited free of metastasis. In a second study, 8-wk-old BALB/c mice were orally administered with resveratrol 12 times and challenged with CT26 cells for 100 days. All control mice died but 50% of the resveratrol-treated mice survived. The surviving mice were challenged with CT26 cells by hypodermic injection, fed with a basal diet for an additional 30 days, and sacrificed. Tumor lumps or nodules were not detected at the injection sites or in the lungs. This reveals that intrinsic vaccination-like defense has resulted from administration of resveratrol and challenge of tumor cells.
PMID: 19862773
This last part is interesting; the surviving mice seem to have developed an immune response against the tumor. Very cool.
Cool indeed.
With regard to vaccination, the resveratrol-administered
mice that survived the challenge of CT26 cells might have
developed an anti-cancer mechanism to destroy the second
challenge with CT26 cells. In our study, the percentages (60
and 88.9%) of mice free of metastasis after administering
resveratrol 12 times prior to challenging with CT26 cells
(experiments 2 and 3) were higher than the percentage in
mice
subjected to administration of resveratrol eight times(57.1% in experiment 1) (Fig. 4). This reveals that duration
of resveratrol administration is important for mice to
potentiate anti-metastatic efficacy after challenge with CT26
cells.
Haha a new soap on
http://www.resforum....at-about-5mgkg/ Makes me think of...what was his name again...ah LifeMirage >> I'm trying to figure out what the problem is but i really don't understand it. Is it a dosage dicussion? What Sinclair uses or what he recommends? Is looking at the downloadable e-book not enough to settle that discussion (Sinclair e-book) If you decide that you want to take resveratrol, consider taking no more than 250 mg per day*_
Anyways, that's probably belongs to a different topic. I was curious but really cannot follow the discussion nor pinpoint the problem :( Too bad such a discussion is going on outside the board. Not good for Imminst image i guess.
Edited by drmz, 18 November 2009 - 04:29 PM.