61 replies to this topic

[TheFountain]

I haven't read up on this much but I know that turmeric is suppose to be a good anti-inflammatory as well as a plethora of other benefits. But is it the best supplement for this? If there are any better what are they?

[shaggy]

I'd say curcumin must be one of the best from what I've read, if you can absorb a significant amount of it!

Edited by shaggy, 20 November 2009 - 10:25 PM.

[meat250]

curcumin WITH BIOPERINE, and grape seed extract are prolly some of the best...also noni has been showing good signs

Meat

[NDM]

Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.

[shaggy]

curcumin WITH BIOPERINE, and grape seed extract are prolly some of the best...also noni has been showing good signs

Meat

Does bioperine make a difference in humans?

Fish oils worth a mention too.

[malbecman]

NSAIDs

Boswellic acids, aka acetyl-11-keto-beta-boswellic acid (AKBA)

Wait, that's 2.......

[meat250]

Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.

it has been proven that curcumin is very poorly absorbed, i wanna say around 5%(without Bioperine)! so it is imperative that bioperine is added, as most products do contain it already

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

[meat250]

NSAIDs

Boswellic acids, aka acetyl-11-keto-beta-boswellic acid (AKBA)

Wait, that's 2.......

good one, also 5-loxin

[shaggy]

Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.

it has been proven that curcumin is very poorly absorbed, i wanna say around 5%(without Bioperine)! so it is imperative that bioperine is added, as most products do contain it already

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

Nice copy and paste.. But little substance in Bioperine's efficacy at improving bioavalabity of curcumin in humans.

If absorbtion of curcumin is 5%, what is it with added bioperine?

[EdwardCTV]

what kind of inflammatory things are u guys suffering from? just wondering what effect an anti inflammatory has on the body in general

[meat250]

Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.

it has been proven that curcumin is very poorly absorbed, i wanna say around 5%(without Bioperine)! so it is imperative that bioperine is added, as most products do contain it already

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

Nice copy and paste.. But little substance in Bioperine's efficacy at improving bioavalabity of curcumin in humans.

If absorbtion of curcumin is 5%, what is it with added bioperine?

bioperine enhances curcumins BA several hundred fold:

[niner]

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

Bioperine does enhance absorption, but this explanation is just BS.

[meat250]

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

Bioperine does enhance absorption, but this explanation is just BS.

you gotta a better explanation.....

[niner]

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

Bioperine does enhance absorption, but this explanation is just BS.

you gotta a better explanation.....

Piperine (Bioperine) is a 3A4 inhibitor, and like many 3A4 inhibitors, it is a PGP efflux pump inhibitor. Any compound that is pumped out ("anti-absorbed") by PGP will be absorbed better in the presence of piperine. Piperine is also said to alter the microstructure of the intestinal brush border in ways that enhance absorption. Depending on species, piperine may alter phase II metabolic enzymes, but this doesn't appear to be the case in humans. It has some fairly complicated effects on pharmacokinetics. It shows a fairly substantial effect on the absorption of curcumin. The question that you have to ask yourself about piperine is what else is it helping to get in? Something you don't want in?

[meat250]

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

Bioperine does enhance absorption, but this explanation is just BS.

this better?


A thermonutrient such as BioPerine would potentially improve the process of nutrient absorption by
enhancing thermogenesis. The leading theory of food-induced thermogenesis relates to the autonomous
nervous system. The autonomous nervous system is represented by two main receptors in the
gastrointestinal tract, the alpha and beta adrenergic receptors.
Most of the food or thermonutrient-induced thermogenesis is facilitated by beta receptors, which
include a compound known as cyclic adenosine 3’, 5’ monophosphate (cAMP). The role of cAMP as a
"second messenger" to the hormonal and enzymatic actions in the body is well recognized. When
thermogenesis occurs, the demand for fresh nutrients to sustain the metabolic processes rapidly
increases.
Piperine has been found in independent studies to stimulate the release of catecholamines, thermogenic
hormones whose action is made possible by the presence of cAMP. However, the nature of the
thermogenic response mediated by catecholamines is relatively short-lived. Therefore the window of
opportunity for piperine-induced thermogenesis and enhanced nutrient absorption is narrow.
These thermogenic properties may explain how a small amount of BioPerine(5 mg) can afford such a
profound effect on serum nutrient levels (as shown in our studies on water soluble, fat soluble and
botanical ingredients). It is possible that when piperine is ingested, it has a localized thermogenic
effect on epithelial cells which increase the uptake of nutrients.
Other mechanisms by which piperine stimulates nutrient absorption have also been discussed in
literature. These include increased micelle formation, stimulation of active transport of amino acids
(gamma-glutamyl transpeptidase), and epithelial cell wall modification due to the affinity of piperine
towards fats and fatty substances.
In view of these findings it is proposed that piperine ingested in relatively small amounts would act as
a thermonutrient. Localized thermogenic action on the epithelial cells would in turn increase the rate of
absorption of supplemented nutrient(s)

[niner]

this better?

A thermonutrient such as BioPerine would potentially improve the process of nutrient absorption by
enhancing thermogenesis. The leading theory of food-induced thermogenesis relates to the autonomous
nervous system. The autonomous nervous system is represented by two main receptors in the
gastrointestinal tract, the alpha and beta adrenergic receptors.
Most of the food or thermonutrient-induced thermogenesis is facilitated by beta receptors, which
include a compound known as cyclic adenosine 3’, 5’ monophosphate (cAMP). The role of cAMP as a
"second messenger" to the hormonal and enzymatic actions in the body is well recognized. When
thermogenesis occurs, the demand for fresh nutrients to sustain the metabolic processes rapidly
increases.
Piperine has been found in independent studies to stimulate the release of catecholamines, thermogenic
hormones whose action is made possible by the presence of cAMP. However, the nature of the
thermogenic response mediated by catecholamines is relatively short-lived. Therefore the window of
opportunity for piperine-induced thermogenesis and enhanced nutrient absorption is narrow.
These thermogenic properties may explain how a small amount of BioPerine(5 mg) can afford such a
profound effect on serum nutrient levels (as shown in our studies on water soluble, fat soluble and
botanical ingredients). It is possible that when piperine is ingested, it has a localized thermogenic
effect on epithelial cells which increase the uptake of nutrients.
Other mechanisms by which piperine stimulates nutrient absorption have also been discussed in
literature. These include increased micelle formation, stimulation of active transport of amino acids
(gamma-glutamyl transpeptidase), and epithelial cell wall modification due to the affinity of piperine
towards fats and fatty substances.
In view of these findings it is proposed that piperine ingested in relatively small amounts would act as
a thermonutrient. Localized thermogenic action on the epithelial cells would in turn increase the rate of
absorption of supplemented nutrient(s)

I don't see how thermogenesis is going to substantially alter pharmacokinetics. It's basically a bunch of speculation and marketing talk. They do give a nod toward the literature, talking about the micelle formation, AA active t'port, and some reference the epithelial cell wall. The whole thing seems marketing-oriented, kind of obfuscutory, and not super consumer-friendly.

[abelard lindsay]

I'd say that Cissus quadrangularis is the most effective supplement I've used by far for joint inflammation.

Petroleum ether extract of Cissus quadrangularis (Linn.) enhances bone marrow mesenchymal stem cell proliferation and facilitates osteoblastogenesis.

Potu BK, Bhat KM, Rao MS, Nampurath GK, Chamallamudi MR, Nayak SR, Muttigi MS.

Department of Anatomy, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

OBJECTIVE: To evaluate the effects of the petroleum ether extract of Cissus quadrangularis on the proliferation rate of bone marrow mesenchymal stem cells, the differentiation of marrow mesenchymal stem cells into osteoblasts (osteoblastogenesis) and extracellular matrix calcification. This study also aimed to determine the additive effect of osteogenic media and Cissus quadrangularis on proliferation, differentiation and calcification. METHODS: MSCs were cultured in media with or without Cissus quadrangularis for 4 weeks and were then stained for alkaline phosphatase. Extracellular matrix calcification was confirmed by Von Kossa staining. marrow mesenchymal stem cells cultures in control media and osteogenic media supplemented with Cissus quadrangularis extract (100, 200, 300 microg/mL) were also subjected to a cell proliferation assay (MTT). RESULTS: Treatment with 100, 200 or 300 microg/mL petroleum ether extract of Cissus quadrangularis enhanced the differentiation of marrow mesenchymal stem cells into ALP-positive osteoblasts and increased extracellular matrix calcification. Treatment with 300 microg/mL petroleum ether extract of Cissus quadrangularis also enhanced the proliferation rate of the marrow mesenchymal stem cells. Cells grown in osteogenic media containing Cissus quadrangularis exhibited higher proliferation, differentiation and calcification rates than did control cells. CONCLUSION: The results suggest that Cissus quadrangularis stimulates osteoblastogenesis and can be used as preventive/ alternative natural medicine for bone diseases such as osteoporosis.

PMID: 19841707 [PubMed - in process]

J Ethnopharmacol. 2007 Mar 21;110(2):264-70. Epub 2006 Sep 26.
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.

Panthong A, Supraditaporn W, Kanjanapothi D, Taesotikul T, Reutrakul V.

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. apanthon@mail.med.cmu.ac.th

Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.

PMID: 17095173 [PubMed - indexed for MEDLINE]

Edited by abelard lindsay, 21 November 2009 - 07:55 AM.

[shaggy]

Feverfew is one of the most powerful and acts upstream, directly on NF-kB, but there is some toxicity from long-term use.

it has been proven that curcumin is very poorly absorbed, i wanna say around 5%(without Bioperine)! so it is imperative that bioperine is added, as most products do contain it already

How does Bioperine® work?
The metabolic process that generates energy at the cellular level in the human body is called thermogenesis.
Though thermogenesis has been identified as a key factor in maintaining weight loss,
it has also been identified as playing an integral role in utilizing the daily food and nutrients that the
human body consume s. It sets in motion the mechanisms that lead to digestion and subsequent
gastrointestinal absorption. Piperine, in the patented form of Bioperine®enhances the body's natural
thermogenic activity - hence the term Thermonutrient®.
This enhancement may be explained as a means of increasing the thermal energy sufficient to
"power up" the mechanism related to thermogenesis. This in turn results in increased metabolic
processes that creates a "demand" for "supply" of a broad range of nutrients that contribute to metabolism,
i.e. vitamins, minerals, herbals, amino acids, etc. It is as if Bioperine® activates a metabolic
paddle wheel, of sorts, that selectively provides a more efficient mode of nutrient
transportation into the blood.

Nice copy and paste.. But little substance in Bioperine's efficacy at improving bioavalabity of curcumin in humans.

If absorbtion of curcumin is 5%, what is it with added bioperine?

bioperine enhances curcumins BA several hundred fold:

This graph is a human study, yes?

[JLL]

There is a human study that showed 2000% increase in absorption (or bioavailability, I'm confused) with piperine. What's so great about Bioperine compared to ordinary black pepper?

[ajnast4r]

turmeric is the most effective for me, the only one i was able to feel physically...much more so than nsaids. i used gaia herbs turmeric extract, which is a full spectrum extract w/ only ~30mg of curcumin.

[hyper_ventriloquism]

I've had excellent results with Zyflamend, which i think is the #1 anti-inflammatory supp sales-wise. I've also had fantastic joint inflammation reduction from bromelain.

Edited by hyper_ventriloquism, 21 November 2009 - 05:50 PM.

[Justchill]

Why do people generally want ANTI-inflammatory supps. Is inflammation not a healing reaction of the body? Why do you want to stop that process ?

[Lufega]

Even MSM has antiinflammatory properties. I recently hurt one of the rotator cuff tendons in my right shoulder and MSM was the only thing that eliminated the pain and inflammation. I even think it healed since it doesn't hurt when I lift weights anymore. Anti-inflammatory and healing at the same time. Who would have thought !

The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages.
Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK.
Source
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Korea.


Abstract
Methylsulfonylmethane (MSM), also known as dimethyl sulfone and methyl sulfone, is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals, including humans. In the present study, we demonstrated the anti-inflammatory effects of MSM in lipopolysaccharide (LPS)-stimulated murine macrophages, RAW264.7 cells. MSM significantly inhibited the release of nitric oxide and prostaglandin E(2) by alleviating the expression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated RAW264.7 cells. Furthermore, the levels of interleukin-6 and tumor necrosis factor-alpha were decreased by MSM treatment in cell culture supernatants. Further study indicated that the translocation of the p65 subunit of nuclear factor (NF)-kappaB to the nucleus was inhibited by MSM treatment in LPS-stimulated RAW264.7 cells, in which it helped block degradation of inhibitor of NF-kappaB. In addition, in vivo studies demonstrated that topical administration of MSM at 500-1250 microg/ear resulted in similar inhibitory activities in 12-O-tetradecanoylphorbol 13-acetate-induced mouse ear edema. Collectively, theses results indicate that MSM inhibits LPS-induced release of pro-inflammatory mediators in murine macrophages through downregulation of NF-kappaB signaling.

[Ames]

In the interest of not letting this perfectly good and nicely focused thread go to waste, I'm going to bump it instead of starting a new one.

Calea zacatechichi and NF-kappaB inhibition

I've noticed a potent, unexpected, and long lasting neuro anti-inflammatory effect after vaporizing the leaves of Calea zacatechichi. It is sold for enhanced dreaming, which it works for, but ironically I find that effect secondary to its impressive anti-inflammatory action in the brain. Although there's a paucity of research on the plant, the information that is available indicates that its primary method of action is through sesquiterpene lactone inhibition of NF-kB, similar to feverfew. In fact, my response to it, and subsequent brief research, is what led me to find out about feverfew.

I would be interested to learn of other sources of sesquiterpene lactones, and by extension NF-kB inhibition, as my experience with Calea z. indicates that sesquiterpene lactone containing plants may vary in acceptable methods of ingestion. Calea z. is the nastiest tasting thing that you will likely ever ingest (tea) or smoke. Although, vaporizing is't too bad as long as you are constantly vaping fresh leaves. If they get too burnt, the bitter taste will knock you down. Also, the NF-kB inhibition property seems to work best via inhalation, but more experimentation is required. Perhaps that's my perception only because I require the anti-inflammatory to cross the BBB. If I had body pain, I'd likely be better able to gauge the systemic effect of ingested plant matter. I've also capped the leaves, but only once or twice. While present to some degree, I don't have a handle on the neurological effects of ingesting of the capped plant matter yet. My initial experiences indicate that vaporizing / smoking is much more potent neurologically than is ingestion, likely for the before mentioned reason of the BBB. The anti-inflammatory effect compounds with multiple days of use.

I'd prefer a cleaner method of NF-kB inhibition than vaporizing or ingesting raw plant matter, but the effects are impressive enough that that is what I shall likely continue to do if a better alternative isn't found. I'll look forward to comparing feverfew ingestion (I won't assume that smoking it is a good idea) with what I am now experiencing with Calea z. Again, other suggestions for NF-kB inhibitors will be appreciated.

As an end note, I've heard that the relative activity of Calea zacatechichi varies with the strain of plant. It's unlikely that there is a way to gauge the relative level of effectiveness between two leaf stocks of the plant before buying, and so, if interested, I would recommend buying based on the reputation of the vendor. Also, you will need a vaporizer. I can't imagine the nastiness of inhaling the smoke, but lots of people apparently do. Last, I only have the leaves. Many vendors sell the leaves with the flowers. I can't comment on whether or not the flowers are a desirable part of the plant, but given that my vendor (Netherlands-based) was of high reputation I would lean towards 'no'. It is difficult to get without flowers, so you may want to pick them out.

Boswellia (serrata, sacra, etc.)

Switching to the topic of another aforementioned anti-inflammatory, I'm a huge face of Boswellia / acetyl-11-keto-beta-boswellic acid (AKBA). Acutally, my first introduction to it was with an essential oil preparation, which I continue to use in a specific manner to good effect on inflamed eyes (I put 3 drops in my hands, rub them together, and cup over my eyes). I've also ingested a solution of a very specific type of the raw resin (dumb, I'm aware) that is reserved for that exact type of intake by wealthier people in the ME. According to my experiments, the effect isn't the same with other types of the resin. I assume that the resin that I had just contains a higher concentration of the active Boswellic acids. The effects were impressive enough that I've ordered some LEF 5-LOX that I hope will be a cleaner, safer way of duplicating the whole-body anti-inflammatory action of the ingested resin. The feeling was very specific and was noticeable mostly during sleep, and so I'll know by the next day if it's the same. Although I repeated the experiment twice with success, I'm not comfortable with long term repetition of the experiment due to possible contaminant issues in the raw resin. Anyway, yes to Boswellic acid.

Edited by golgi1, 19 April 2013 - 04:55 PM.

[revenant]

I use reishi and fish oil. http://reishi.setame...culos/art12.pdf

[niner]

Since this thread has woken up and there is a new substance available, I think it deserves a mention. C60-olive oil is useful against certain kinds of chronic inflammation. It probably will not do a lot for acute inflammation. That's a pretty good thing, really, since acute inflammation may be helpful, but chronic inflammation rarely (if ever) is. I had eczema (a chronic inflammatory skin condition) on my hands for over a decade, and could control it with topical steroids, but could never completely get rid of it. After being on c60-oo for a couple months, I was finally rid of it for good. I also got rid of another chronic skin condition, which may or may not have been eczema, and I've found that I have less stiffness or soreness if I neglect to hit the gym.

The pharmaceutical industry has some pretty effective anti-inflammatories. It's one of the things they're fairly good at, particularly the non-steroidals. Steroids are amazing anti-inflammatories, but their side effects totally suck. However, big pharma doesn't have anything quite like c60-oo.

[Ames]

C60-olive oil is useful against certain kinds of chronic inflammation.

Niner, I've been back and forth on attempting C-60 a couple of times in the past 5-6 months. Both times, I decided against (although, I forget specifically why at the moment). Perhaps I was just being over-cautious, which is ironic given my recent admission to downing Omani desert harvested tree resin, huh? Anyway, As someone who has been on it for a while, could you break down some of the potential risks of C-60 ingestion and how you view them, perhaps in the light of your experienced rewards? If you don't have the time, that's cool too. I thought I'd ask given that it might be a helpful 'quick reference' adjunct to the mini anti-inflammatory wiki that we're starting to build here.

Edited by golgi1, 19 April 2013 - 10:01 PM.

[niner]

The c60-oo risks that we know about aren't too bad. One is that it subverts a certain type of muscle fatigue, allowing weightlifters to do more reps than they really should. As a result, several of us have injured ourselves. (Including me. I'm back to normal now.) Another effect, which might be viewed as both a minus and a plus, involves the way that people feel after exercise. A couple people have reported that they don't get the "endorphin" feeling after they work out. I've noticed this, although I've also noticed that I don't feel so bad if I don't work out, which is a reasonable tradeoff. This might vary depending on the intensity of your workout- mine isn't very intense. A third thing that might be considered a negative involves drinking- I don't feel as drunk for a given amount of alcohol. Lots of people have reported that their alcohol tolerance is greater. I'm not sure if that's a reference to the alcohol high or to the aftereffects, which are also better. Some people report a reduced tolerance to caffeine, although I haven't noticed that.

Beyond this, other risks are in the category of unknown/hypothetical. We don't know what effect it has on development. Maybe nothing, or maybe it's another thalidomide. Because we just don't know, I wouldn't recommend it for a women who is or might get pregnant. I also wouldn't give it to kids without an extraordinary reason, like congenital mitochondrial dysfunction. As we learn more about it, we should be able to decide if these cautions are necessary or not. A hypothetical downside is adaptation to exercise. Since c60 is an antioxidant, would it cause us to have less adaptation/hypertrophy? So far, no one has noticed anything obvious. Another hypothetical is the effect it might have on cancer. If you already had cancer, c60 might be a bad idea because cancer cells have a lot of oxidative stress and tend to deplete their endogenous antioxidant reserves. You wouldn't want to refresh those reserves and help them out. That's something of a generic problem with antioxidants. On the plus side with respect to cancer is the possibility that c60-oo is a cancer preventative. Wistar rats are quite susceptible to cancer, and Baati's control rats had the usual number of tumors. The c60-oo rats, despite living far longer, had no tumors at all when they died.

[nowayout]

So it might mess with the enorphin/dopamine/reward system. That sounds kind of bad to me.

[zorba990]

liposomal curcumin seems powerful http://www.ncbi.nlm....pubmed/21745189