• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

Cancer


  • Please log in to reply
119 replies to this topic

#91 Zenob

  • Guest, F@H
  • 328 posts
  • 1

Posted 10 October 2008 - 01:05 AM

This one looks pretty promising. It's a newly discovered virus that is basically harmless to people but seems to really like eating cancer cells. Here's an excerpt:

"Further investigation found that the virus was harmless to normal human cells, but could infect certain solid tumors, such as small cell lung cancer, the most common form of lung cancer. Scientists at Neotrophix say that, in laboratory and animal studies, the virus demonstrates cancer-killing specificity that is 10,000 times higher than that seen in traditional chemotherapeutics, with no overt toxicity."

Link


Found this one shortly after posting, figured I'd make it a twofer. A new study indicates that Bisphenol(chemical used in most plastics) protects cancer cells from chemo. This makes me think I need to start buying more glassware instead of plastic containers. Especially microwave containers. When you heat these things up is when bisphenol leeches out of them.
Link

Edited by Zenob, 10 October 2008 - 01:30 AM.


#92 Mind

  • Life Member, Director, Moderator, Treasurer
  • 18,997 posts
  • 2,000
  • Location:Wausau, WI

Posted 16 October 2008 - 09:59 PM

Ancient Chinese Salad Plant Transformed Into New Cancer-killing Compound

Except for the "Ancient Chinese" part, this sounds pretty interesting. This is another meta material-type breakthrough where artemisinin is modified with some other carrier compounds so that it has a strong affinity for cancer cells and not normal cells. Otherwise, artemisinin has had a long history in the "cancer miracle breakthrough" headlines, yet I haven't seen much success. Maybe this is the breakthough that is needed, and perhaps other cancer killing molecules can be modified in a similar manner to increase their effectiveness.

The scientists attached a chemical homing device to artemisinin that targets the drug selectively to cancer cells, sparing healthy cells. The results were published online Oct. 5 in the journal Cancer Letters.

"The compound is like a special agent planting a bomb inside the cell," said Tomikazu Sasaki, chemistry professor at UW and senior author of the study.

In the study, the UW researchers tested their artemisinin-based compound on human leukemia cells. It was highly selective at killing the cancer cells. The researchers also have preliminary results showing that the compound is similarly selective and effective for human breast and prostate cancer cells, and that it effectively and safely kills breast cancer in rats, Sasaki said.

Cancer drug designers are faced with the unique challenge that cancer cells develop from our own normal cells, meaning that most ways to poison cancer cells also kill healthy cells. Most available chemotherapies are very toxic, destroying one normal cell for every five to 10 cancer cells killed, Sasaki said. This is why chemotherapy's side effects are so devastating, he said.

"Side effects are a major limitation to current chemotherapies," Sasaki said. "Some patients even die from them."

The compound Sasaki and his colleagues developed kills 12,000 cancer cells for every healthy cell, meaning it could be turned into a drug with minimal side effects. A cancer drug with low side effects would be more effective than currently available drugs, since it could be safely taken in higher amounts.

The artemisinin compound takes advantage of cancer cell's high iron levels. Artemisinin is highly toxic in the presence of iron, but harmless otherwise. Cancer cells need a lot of iron to maintain the rapid division necessary for tumor growth.

Since too much free-floating iron is toxic, when cells need iron they construct a special protein signal on their surfaces. The body's machinery then delivers iron, shielded with a protein package, to these signals proteins. The cell then swallows this bundle of iron and proteins.



sponsored ad

  • Advert
Click HERE to rent this MEDICINES advertising spot to support LongeCity (this will replace the google ad above).

#93 bixbyte

  • Guest
  • 559 posts
  • 45
  • Location:End of the Galaxy
  • NO

Posted 16 October 2008 - 11:43 PM

NOVO TWO = GLUTOXIM

Medication not approved in the US and shown to selectively Kill cancer cells when used adjunct with standard chemotherapy


sold in the US by Novelos Therapeutics

Waiting for FDA approval, Phase III, Fast Track, under Special Protocol Assessment

__________________________________________________________________________

INSTRUCTION ON MEDICAL APPLICATION

GLUTOXIM

0.5%, 1%, AND 3% SOLUTION OF GLUTOXIM FOR INJECTIONS

International unpatented name: Disodium salt of bis-(g -L-glutamyl)-L-cysteinyl-bis-glycine.

Active principle: glutoxim (Disodium salt of bis-(g -L-glutamyl)-L-cysteinyl-bis-glycine).

Additional compounds: isotonic sodium chloride solution.

Colorless transparent liquid.

"Glutoxim" is a chemically synthesized biologically active substance - hexapeptide (disodium salt of bis-(g -L-glutamyl)-L-cysteinyl-bis-glycine) with a sum formula (C20H32O16N6S2).

"Glutoxim" injection form is manufactured as a sterile solution for intramuscular, intravenous and subcutaneous use.

PHARMACOLOGICAL EFFECTS

"Glutoxim" is related to a new class of medical agents - thiopoietins, which has a unique biological activity due to a modulating effect on intracellular processes of thiol metabolism that plays an important role in a genetic and metabolic processes' regulation in cells and tissues.

The basic mechanism of the drug biological and pharmacological efficacy is a regulable escalation of cells' redox state. New level of redox systems and dynamics of phosphorilating of key proteins of signal-transducing systems and transcriptional factors (NFkB and AP-1), first of all, in immunocompetent cells determinates immunomodulating and systemic cell-protective drug effects.

Glutoxim is capable to perform differentiated impact on normal (stimulation of differentiation and proliferation) and on transformed (induction of apoptosis, genetically programmed cell death) cells. Main immune and physiologic drug features are the following: high drug affinity to cells of central immunity organs and lymphoid tissue system; enhancement of bone marrow hemopoiesis - processes of erythropoiesis, lymphopoiesis and granulocyto-monocytopoiesis; phagocytosis system activation including immunodeficiency conditions; restoration of neutrophil, monocyte, lymphocyte counts in peripheral blood and tissue macrophage functional capacities.

Among Glutoxim immune biochemical properties the following should be underlined: drug stimulating effect on cascade mechanisms of phosphate modifications of main proteins of the signal-transducing systems; initiation of cytokine systems including endogenous production of IL-1, IL-6, TNF, IFN, erythropoietin, and reproduction of IL-2 effects through its receptor expression induction.

PHARMACOKINETICS

Glutoxim is related to a group of natural metabolites that determinates its metabolism characteristics by existing cell enzyme system. Biological availability after intramuscular, intravenous and subcutaneous injection exceeds 90%. There is a linear dependence between dose and drug concentration in blood plasma. Maximum drug concentration in plasma after an intravenous introduction is observed in 2-5 min., after an intramuscular introduction - in 7-10 min. As a natural compound of peptide origin Glutoxim is metabolized in organs and tissues being eliminated through kidneys.

INDICATIONS

Glutoxim is administered to adults as an agent for prophylaxis and treatment of secondary immunodeficient conditions induced by radiation, chemical and/or infectious factors; to restore inhibited immune reactions and suppressed bone marrow condition; to enhance body resistance to multifarious pathologic impacts such as infectious agents, chemical and/or physical factors (intoxication, radiation, etc.); as a hepatoprotective agent for acute and chronic viral (B and C) hepatitis eliminating chronic virus-carriage objective signs; to potentate antibacterial therapy effects for chronic obstructive lung diseases; to prevent postoperative suppurative complications.

CONTRAINDICATIONS

Glutoxim introduction is contraindicated only in cases of individual intolerance.

ADVERSE EFFECTS

Some patients may note an insignificant temperature raise (to 37.10C - 37.50C) and tenderness in a drug introduction site. If subjectively such tenderness is tolerated badly it's recommended administering Glutoxim along with 1-2 ml of 0.5% Novocain solution.

DRUG FORMS

In 1.0-ml and 2.0-ml ampoules.

STORAGE CONDITIONS

Glutoxim should be stored in a dry, shadowed place at +40 - +60C.

SHELF LIFE

2 years.

PHARMACY SALE CONDITIONS

Prescribed by a medical doctor.

MANUFACTURER:

PharmaBAM Ltd., 47, Myasnitskaya str., Moscow, Russia.

#94 Dmitri

  • Guest
  • 841 posts
  • 33
  • Location:Houston and Chicago

Posted 21 October 2008 - 04:17 AM

Instead of starting a new thread on cancer prevention I thought I'd ask my question here.

I wanted to know if there's any type of supplement that can reduce or repair the damage my DNA could have sustained from medical radiation scans such as from X-rays and CT scan radiation. For the past week I was exposed to those types of radiation and a few weeks ago when I visited the dentist they did an x-ray scan. I'm worried my DNA has sustained damage from so much radiation. Is there anything that can help my DNA repair itself?

#95 Reno

  • Guest
  • 584 posts
  • 37
  • Location:Somewhere

Posted 21 October 2008 - 02:35 PM

Instead of starting a new thread on cancer prevention I thought I'd ask my question here.

I wanted to know if there's any type of supplement that can reduce or repair the damage my DNA could have sustained from medical radiation scans such as from X-rays and CT scan radiation. For the past week I was exposed to those types of radiation and a few weeks ago when I visited the dentist they did an x-ray scan. I'm worried my DNA has sustained damage from so much radiation. Is there anything that can help my DNA repair itself?


It would take several thousand xray scans to begin to cause harm to your cells. Thats why xray teks stay behind the led wall while they're doing their job. Doing a job like that 8hours a day 7 days a week without a barrier might hurt your dna, while minor exposer most likely won't.

Edited by bobscrachy, 21 October 2008 - 02:38 PM.


#96 Dmitri

  • Guest
  • 841 posts
  • 33
  • Location:Houston and Chicago

Posted 21 October 2008 - 10:41 PM

Instead of starting a new thread on cancer prevention I thought I'd ask my question here.

I wanted to know if there's any type of supplement that can reduce or repair the damage my DNA could have sustained from medical radiation scans such as from X-rays and CT scan radiation. For the past week I was exposed to those types of radiation and a few weeks ago when I visited the dentist they did an x-ray scan. I'm worried my DNA has sustained damage from so much radiation. Is there anything that can help my DNA repair itself?


It would take several thousand xray scans to begin to cause harm to your cells. Thats why xray teks stay behind the led wall while they're doing their job. Doing a job like that 8hours a day 7 days a week without a barrier might hurt your dna, while minor exposer most likely won't.


I see, thank you for the info.

#97 bixbyte

  • Guest
  • 559 posts
  • 45
  • Location:End of the Galaxy
  • NO

Posted 08 December 2008 - 10:40 PM

Instead of starting a new thread on cancer prevention I thought I'd ask my question here.

I wanted to know if there's any type of supplement that can reduce or repair the damage my DNA could have sustained from medical radiation scans such as from X-rays and CT scan radiation. For the past week I was exposed to those types of radiation and a few weeks ago when I visited the dentist they did an x-ray scan. I'm worried my DNA has sustained damage from so much radiation. Is there anything that can help my DNA repair itself?





I would suggest you try taking the combination of NAC along with a daily dose of Selenium in an attempt to increase your cellular levels of Glutatthione.

Maybe help repair or reduce damage from radiation exposure.

The sure way to treat radiation exposure is to find a very small supply of NOVO-TWO that is not available in the USA.

http://www.novelos.com/

#98 bixbyte

  • Guest
  • 559 posts
  • 45
  • Location:End of the Galaxy
  • NO

Posted 08 December 2008 - 10:49 PM

PLEIOTROPIC

Pleiotropy occurs when a single gene influences multiple phenotypic traits. Consequently, a new mutation in the gene will have an effect on all traits


http://www.novelos.c...-002_poster.pdf


That is how NOVO-TWO works!

spent side Oxidized Glutathione is Pleiotropic

Gadzooks I am the cookie monster :-D

<LOL>

____________________________________________________________


NOVO TWO = GLUTOXIM

Medication not approved in the US and shown to selectively Kill cancer cells when used adjunct with standard chemotherapy


sold in the US by Novelos Therapeutics

Waiting for FDA approval, Phase III, Fast Track, under Special Protocol Assessment

__________________________________________________________________________

INSTRUCTION ON MEDICAL APPLICATION

GLUTOXIM

0.5%, 1%, AND 3% SOLUTION OF GLUTOXIM FOR INJECTIONS

International unpatented name: Disodium salt of bis-(g -L-glutamyl)-L-cysteinyl-bis-glycine.

Active principle: glutoxim (Disodium salt of bis-(g -L-glutamyl)-L-cysteinyl-bis-glycine).

Additional compounds: isotonic sodium chloride solution.

Colorless transparent liquid.

"Glutoxim" is a chemically synthesized biologically active substance - hexapeptide (disodium salt of bis-(g -L-glutamyl)-L-cysteinyl-bis-glycine) with a sum formula (C20H32O16N6S2).

"Glutoxim" injection form is manufactured as a sterile solution for intramuscular, intravenous and subcutaneous use.

PHARMACOLOGICAL EFFECTS

"Glutoxim" is related to a new class of medical agents - thiopoietins, which has a unique biological activity due to a modulating effect on intracellular processes of thiol metabolism that plays an important role in a genetic and metabolic processes' regulation in cells and tissues.

The basic mechanism of the drug biological and pharmacological efficacy is a regulable escalation of cells' redox state. New level of redox systems and dynamics of phosphorilating of key proteins of signal-transducing systems and transcriptional factors (NFkB and AP-1), first of all, in immunocompetent cells determinates immunomodulating and systemic cell-protective drug effects.

Glutoxim is capable to perform differentiated impact on normal (stimulation of differentiation and proliferation) and on transformed (induction of apoptosis, genetically programmed cell death) cells. Main immune and physiologic drug features are the following: high drug affinity to cells of central immunity organs and lymphoid tissue system; enhancement of bone marrow hemopoiesis - processes of erythropoiesis, lymphopoiesis and granulocyto-monocytopoiesis; phagocytosis system activation including immunodeficiency conditions; restoration of neutrophil, monocyte, lymphocyte counts in peripheral blood and tissue macrophage functional capacities.

Among Glutoxim immune biochemical properties the following should be underlined: drug stimulating effect on cascade mechanisms of phosphate modifications of main proteins of the signal-transducing systems; initiation of cytokine systems including endogenous production of IL-1, IL-6, TNF, IFN, erythropoietin, and reproduction of IL-2 effects through its receptor expression induction.

PHARMACOKINETICS

Glutoxim is related to a group of natural metabolites that determinates its metabolism characteristics by existing cell enzyme system. Biological availability after intramuscular, intravenous and subcutaneous injection exceeds 90%. There is a linear dependence between dose and drug concentration in blood plasma. Maximum drug concentration in plasma after an intravenous introduction is observed in 2-5 min., after an intramuscular introduction - in 7-10 min. As a natural compound of peptide origin Glutoxim is metabolized in organs and tissues being eliminated through kidneys.

INDICATIONS

Glutoxim is administered to adults as an agent for prophylaxis and treatment of secondary immunodeficient conditions induced by radiation, chemical and/or infectious factors; to restore inhibited immune reactions and suppressed bone marrow condition; to enhance body resistance to multifarious pathologic impacts such as infectious agents, chemical and/or physical factors (intoxication, radiation, etc.); as a hepatoprotective agent for acute and chronic viral (B and C) hepatitis eliminating chronic virus-carriage objective signs; to potentate antibacterial therapy effects for chronic obstructive lung diseases; to prevent postoperative suppurative complications.

CONTRAINDICATIONS

Glutoxim introduction is contraindicated only in cases of individual intolerance.

ADVERSE EFFECTS

Some patients may note an insignificant temperature raise (to 37.10C - 37.50C) and tenderness in a drug introduction site. If subjectively such tenderness is tolerated badly it's recommended administering Glutoxim along with 1-2 ml of 0.5% Novocain solution.

DRUG FORMS

In 1.0-ml and 2.0-ml ampoules.

STORAGE CONDITIONS

Glutoxim should be stored in a dry, shadowed place at +40 - +60C.

SHELF LIFE

2 years.

PHARMACY SALE CONDITIONS

Prescribed by a medical doctor.

MANUFACTURER:

PharmaBAM Ltd., 47, Myasnitskaya str., Moscow, Russia.



#99 rhodan

  • Guest
  • 76 posts
  • 0
  • Location:Paris, France

Posted 12 December 2008 - 02:42 PM

Killing cancer cells in the bloodstream

In a new tactic in the fight against cancer, Cornell researcher Michael King has developed what he calls a lethal "lint brush" for the blood -- a tiny, implantable device that captures and kills cancer cells in the bloodstream before they spread through the body.


King's group tested the device on prostate and colon cancer cells, but noted that it could also be customized with additional peptides or other proteins to target other types of cancer cells. "And if you could reduce or prevent metastasis, pretty much any cancer would be treatable," he said.



#100 rhodan

  • Guest
  • 76 posts
  • 0
  • Location:Paris, France

Posted 19 December 2008 - 09:03 AM

New anti-cancer components of extra-virgin olive oil revealed

Menendez and colleagues separated the oil into fractions and tested these against breast cancer cells in lab experiments. All the fractions containing the major extra-virgin phytochemical polyphenols (lignans and secoiridoids) were found to effectively inhibit HER2


"These findings, together with the fact that that humans have safely been ingesting significant amounts of lignans and secoiridoids as long as they have been consuming olives and extra-virgin oil, strongly suggest that these polyphenols might provide an excellent and safe platform for the design of new anti breast-cancer drugs"



#101 tham

  • Guest
  • 1,406 posts
  • 498
  • Location:Kuala Lumpur, Malaysia

Posted 19 December 2008 - 06:55 PM

Garlic and onions could help prevent men developing
prostate cancer, researchers have said.



Onions outperform garlic.

http://www.ncbi.nlm....l=pubmed_docsum

#102 FunkOdyssey

  • Guest
  • 3,443 posts
  • 166
  • Location:Manchester, CT USA

Posted 19 December 2008 - 06:57 PM

I'm guessing quercetin is responsible for the onion advantage. It is better absorbed from onions than any other common food source.

Edited by FunkOdyssey, 19 December 2008 - 07:06 PM.


#103 Mind

  • Life Member, Director, Moderator, Treasurer
  • 18,997 posts
  • 2,000
  • Location:Wausau, WI

Posted 22 December 2008 - 08:36 PM

Modified Gene Targets Cancer Cells One Thousand Times More Often Than Healthy Cells

Vera Gorbunova, assistant professor of biology at the University of Rochester, and her team, Andrei Seluanov, assistant professor of biology, and graduate student Christopher Hine, were investigating Rad51, a protein that is expressed at about five times higher level in cancer cells than in healthy cells, when they stumbled on something very unexpected.

"We stripped off some of the Rad51 gene and replaced it with a marker protein DNA to see why Rad51 was five times more abundant in cancer cells," says Gorbunova. "We wanted to see if there was any way we could boost that difference and create a really useful cancer-targeting tool. We couldn't believe it when we saw the cancer cells expressing the engineered Rad51 around a thousand times more."

When Gorbunova first saw the huge discrepancy, she thought one of her graduate students had fumbled the lab test. Further tests showed that the altered Rad51 was expressed in some cancer cells as much as 12,500 times as often as healthy cells, says Gorbunova. Such a large discrepancy means scientists should be able to use it to create versions of Rad51 that carry a "toxic bomb," which only the cancer cells will trigger.



#104 rhodan

  • Guest
  • 76 posts
  • 0
  • Location:Paris, France

Posted 12 January 2009 - 06:38 PM

Reprogramming immune system to attack cancer

Implants that sit in the body and reprogram a person's immune cells could be used to treat a range of infectious diseases and even cancer


Their breakthrough involves implanting cylinders of an FDA-approved biodegradable polymer into the body. The implants release a particular variety of the cell-signalling molecules called cytokines - a sort of molecular perfume that is irresistible to a certain kind of immune-system messenger cell.

These dendritic cells are attracted into the pores of Mooney's implant, where they are exposed to antigens - the molecular signatures of the cancer, bacterium or virus being treated - and a danger-signal chemical derived from bacterial DNA.

This alert signal makes the dendritic cells flee to the nearest lymph node, where they meet up with the immune system's "killer" T-cells and program them to hunt down the invading cells.



#105 Mind

  • Life Member, Director, Moderator, Treasurer
  • 18,997 posts
  • 2,000
  • Location:Wausau, WI

Posted 01 March 2009 - 02:52 PM

Suppressing Cancer with a Master Control Gene

New work conducted by Wouter Bossuyt, Bassem Hassan, and colleagues at VIB and K. U. Leuven has tested this theory. They demonstrate that in the fruit fly, master control genes steering the specialization step inhibit tumor formation.

In collaboration with colleagues from the United States, they show that loss of one of those genes, Atonal homolog 1 (ATOH1), causes colon cancer in mice. The gene regulates the last step in the specialization to epithelial cells of the colon. Humans with colon cancer frequently have an inactivated ATOH1 gene, the researchers show.

The researchers could reactivate the gene in human colon cancer cells grown in culture. This caused the tumor cells to stop growing and commit suicide. This exciting, but preliminary, result suggests that it may be possible to switch the gene back on in living patients to target their cancers. Taking this work in the test tube and using it to develop a therapy is an exciting but complicated challenge. Therefore, more work will be required to further understand the role of ATOH1 in suppressing cancer formation.



#106 rhodan

  • Guest
  • 76 posts
  • 0
  • Location:Paris, France

Posted 24 March 2009 - 10:22 PM

Nitric Oxide attached to B12 to kill cancer cells thru over-expressed B12 receptors

In order to divide at their abnormally rapid pace, cancer cells grow extra B12 receptors — 100 times more than normal cancer cells.


Bauer and his colleagues from the Cleveland Clinic attached nitric oxide (NO) molecules to vitamin B12. NO kills cancer cells. The B12 acts as the Trojan horse, easily slipping into cancer cells. The subsequent release of toxic NO kills the cancer cells from within.


Edited by rhodan, 24 March 2009 - 10:23 PM.


#107 Hedgehog

  • Guest
  • 462 posts
  • 1

Posted 29 March 2009 - 09:04 PM

Attacking cancer stem cells as a new approach to stopping the disease

All cancer cells were once thought to be equal, but recent research suggests otherwise. A growing body of evidence indicates that only certain cancer cells are capable of generating and maintaining a tumor. Dubbed cancer stem cells, they can divide indefinitely to perpetuate the cancer over time. They may also be the reason why some therapies fail to wipe out a cancer entirely: cancer stem cells seem to be particularly resistant to standard cancer treatments and can remain behind like the roots of a weed.

If this hypothesis holds true, cancer stem cells could be the most promising target for new therapies. A team of researchers at Harvard Medical School has now developed a new way to find drugs that selectively kill cancer stem cells or prevent them from dividing. The team is currently using the method to identify drug candidates for leukemia, a disease for which cancer stem cells have been well characterized. The researchers believe that the approach could eventually extend to other kinds of cancer.

David Scadden, cochair of the Harvard Stem Cell Institute and a collaborator on the project, says that typical high-throughput drug screens, which use cell lines grown in petri dishes, don't always yield good results because the cells are too removed from their natural context. With stem cells in particular, he says, "the microenvironment seems to be an important contributor for how the cells function." When grown in the lab, the cells can lose their "stemness," or ability to generate new cells. Instead, the Harvard drug-screening method uses cells taken directly from diseased animals.

To better mimic the natural environment of cancer stem cells, the team incorporated other cells that support them. "Cancer cells don't exist in isolation," says Kimberly Hartwell, a research fellow at Brigham and Women's Hospital, who helped lead the project. In tissues, she says, these cells "may hijack the support system--what we call the stromal cells." Stromal cells form connective tissue surrounding an organ; scientists believe that they help provide an environment where stem cells flourish.


x-actly...

The Hedgehog Inhibitor is the first of its kind in the clinic that targets Cancer Stem Cells (hopefully many more will come)... Normal cancer inhibitors only cause everything else but the cancer stem cells to stop growing. "cancer stem cells seem to be particularly resistant to standard cancer treatments and can remain behind like the roots of a weed."

http://www.imminst.o...showtopic=28548

#108 ihatesnow

  • Guest
  • 776 posts
  • 251
  • Location:rochester new york

Posted 07 April 2009 - 07:39 PM

http://www.medicalne...cles/145284.php

#109 ihatesnow

  • Guest
  • 776 posts
  • 251
  • Location:rochester new york

Posted 07 April 2009 - 09:30 PM

http://scienceandrea...-cancer-ii.html



Attacking cancer stem cells as a new approach to stopping the disease

All cancer cells were once thought to be equal, but recent research suggests otherwise. A growing body of evidence indicates that only certain cancer cells are capable of generating and maintaining a tumor. Dubbed cancer stem cells, they can divide indefinitely to perpetuate the cancer over time. They may also be the reason why some therapies fail to wipe out a cancer entirely: cancer stem cells seem to be particularly resistant to standard cancer treatments and can remain behind like the roots of a weed.

If this hypothesis holds true, cancer stem cells could be the most promising target for new therapies. A team of researchers at Harvard Medical School has now developed a new way to find drugs that selectively kill cancer stem cells or prevent them from dividing. The team is currently using the method to identify drug candidates for leukemia, a disease for which cancer stem cells have been well characterized. The researchers believe that the approach could eventually extend to other kinds of cancer.

David Scadden, cochair of the Harvard Stem Cell Institute and a collaborator on the project, says that typical high-throughput drug screens, which use cell lines grown in petri dishes, don't always yield good results because the cells are too removed from their natural context. With stem cells in particular, he says, "the microenvironment seems to be an important contributor for how the cells function." When grown in the lab, the cells can lose their "stemness," or ability to generate new cells. Instead, the Harvard drug-screening method uses cells taken directly from diseased animals.

To better mimic the natural environment of cancer stem cells, the team incorporated other cells that support them. "Cancer cells don't exist in isolation," says Kimberly Hartwell, a research fellow at Brigham and Women's Hospital, who helped lead the project. In tissues, she says, these cells "may hijack the support system--what we call the stromal cells." Stromal cells form connective tissue surrounding an organ; scientists believe that they help provide an environment where stem cells flourish.


x-actly...

The Hedgehog Inhibitor is the first of its kind in the clinic that targets Cancer Stem Cells (hopefully many more will come)... Normal cancer inhibitors only cause everything else but the cancer stem cells to stop growing. "cancer stem cells seem to be particularly resistant to standard cancer treatments and can remain behind like the roots of a weed."

http://www.imminst.o...showtopic=28548




#110 Mind

  • Life Member, Director, Moderator, Treasurer
  • 18,997 posts
  • 2,000
  • Location:Wausau, WI

Posted 04 May 2009 - 11:08 PM

Why do the majority of people never get cancer?

I would say it has a lot to do with the fact that most people die of something else before they have a chance to contract cancer, but of course there is also evidence of innate cancer resistance.

Z. Cui has had much success studying innate resistence in mice.

As Klein explains, the suffering of cancer patients and their families has inspired most cancer researchers to focus on the genetics of cancer susceptibility. On the other hand, the genetics of cancer resistance has been largely unexplored, possibly because it is assumed to be merely the other side of the susceptibility coin. For example, if cancer is caused by mutations in genes that control cell division, then it logically seems that cancer resistance is simply a low occurrence of these mutations.

But, Klein says, maybe there is another alternative to the concept of cancer resistance. Perhaps most people have various protective mechanisms that counteract the development of cancer cells and stop the disease from progressing beyond the earliest stages.

“Cancer resistance must be investigated on its own merits,” Klein told PhysOrg.com. “It is possible and even likely that evolution has provided our species with highly efficient cancer resistance mechanisms. These may be the mechanisms that prevent most circulating, disseminated cancer cells that are found in the blood of all cancer patients to grow into metastasis, and can also nip cancerous foci (islands of cells in, for example, the prostate or the breast) in the bud, so that they do not progress.”



#111 ihatesnow

  • Guest
  • 776 posts
  • 251
  • Location:rochester new york

Posted 11 May 2009 - 11:43 AM

http://www.ncbi.nlm....pubmed/19293772

#112 timziums88

  • Guest
  • 14 posts
  • 0

Posted 13 May 2009 - 10:25 PM

Healthy supplementation and moderation is key on everything. Hopefully scientists can find a resolution for cancer soon though, it's extremely sad, but I think something is close!!

#113 Gerald W. Gaston

  • Guest
  • 529 posts
  • 58
  • Location:USA

Posted 13 May 2009 - 11:14 PM

It would take several thousand xray scans to begin to cause harm to your cells. Thats why xray teks stay behind the led wall while they're doing their job. Doing a job like that 8hours a day 7 days a week without a barrier might hurt your dna, while minor exposer most likely won't.


That is what I always heard until today when the doc called and said that my cervical MRI (taken to look for a bone spur) showed something on the thyroid that they believe is a nodule... and now I must go in for an ultrasound. :) He said that low-level radiation such as from th x-rays I had for my neck issues years ago could have contributed to this. Off to google the accuracy of such a statement now.

#114 ihatesnow

  • Guest
  • 776 posts
  • 251
  • Location:rochester new york

Posted 18 May 2009 - 08:49 AM

http://www.scienceda...90517081157.htm

#115 Mind

  • Life Member, Director, Moderator, Treasurer
  • 18,997 posts
  • 2,000
  • Location:Wausau, WI

Posted 17 October 2009 - 12:05 PM

I thought I would post this here since this cancer thread started out with some natural and homeopathic type potential treatments. No doubt a proper diet can help ward off disease but as far as I have seen, the natural "cures" have not cured too many people of cancer. If they were as successful as claimed, then everyone would be participating and hardly anyone would be dying of cancer.

The Elemental Miracle, some natural homeopathic ideas on preventing and treating cancer.

Thought I would post this link as well in order to help people avoid treatments that have not shown success or are completely fraudulent.

Cancer Treatment Watch.

#116 kismet

  • Guest
  • 2,984 posts
  • 424
  • Location:Austria, Vienna

Posted 17 October 2009 - 12:46 PM

I thought I would post this here since this cancer thread started out with some natural and homeopathic type potential treatments. No doubt a proper diet can help ward off disease but as far as I have seen, the natural "cures" have not cured too many people of cancer. If they were as successful as claimed, then everyone would be participating and hardly anyone would be dying of cancer.

The Elemental Miracle, some natural homeopathic ideas on preventing and treating cancer.

The what doing what using what? Nothing doing nothing and/or poisoning people? May I add that I strongly and greatly disapprove of those links and therein presented options?

Edited by kismet, 17 October 2009 - 12:46 PM.


#117 rhodan

  • Guest
  • 76 posts
  • 0
  • Location:Paris, France

Posted 11 December 2009 - 04:46 PM

Stroke Drug Kills Cancer Cells and Leaves Normal Cells Intact

A never-approved drug developed to prevent the death of nerve cells after a stroke can efficiently kill cancer cells while keeping normal cells healthy and intact, an international team led by a Tel Aviv University researcher is reporting in the journal Breast Cancer Research


We've found a molecular triggering mechanism in cancer cells that, when set off, causes the cancer cells to die -- they just stop multiplying and die within 48 to 72 hours. Normal, healthy body cells are only temporarily arrested by the same mechanism -- they overcome this cell cycle arrest within 12 hours and continue to proliferate in the presence of the drug as normal un-treated cells," says Prof. Cohen-Armon. "All the human cancer cells we tested seemed to succumb to this compound



#118 kismet

  • Guest
  • 2,984 posts
  • 424
  • Location:Austria, Vienna

Posted 11 December 2009 - 05:19 PM

Sigh. Petri dish results.

#119 Ark

  • Guest
  • 1,729 posts
  • 383
  • Location:Beijing China

Posted 07 August 2017 - 01:04 AM

A friend of mine reccently became diagnosed with cervical cancer. What would be the best regime with say a 400-800 a month budget on supplement and drugs?

Thanks, Ark

sponsored ad

  • Advert
Click HERE to rent this MEDICINES advertising spot to support LongeCity (this will replace the google ad above).

#120 HaplogroupW

  • Guest
  • 101 posts
  • 67
  • Location:Flyover country
  • NO

Posted 11 August 2017 - 11:32 PM

I think Thomas Seyfried's thesis "Cancer as a metabolic disease" is intriguing. And it leads to very practical things one can do to treat and prevent (if it's correct).

 

In a nutshell he thinks the that nuclear DNA mutations are down-stream effects, not the root cause. It happens in populations of cells that have have defective mitochondria continually selecting for (epigenetic?) mutations that allow the cell to survive via fermentation (if I got it right).

 

A part of his argument refers to experiments that has been duplicated and published several times where the nucleus of cancer cells is transplanted into fertilized egg having healthy mitochondria and cytoplasm that go on to develop normally; they don't remain cancerous. This shouldn't happen if the nuclear mutations were the root cause and defining characteristic.

 

He also shows some animal studies data and case studies (human and dog) that are interesting.

 

I think he coves it pretty well here:

 

 

 






1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users