,Just upped the dose from 350 mg to 750 mg two days ago. First noticeable effects were dry mouth and mild tachycardia (my pulse went from mid 70's to mid 80's). Also, my sleep was more disturbed last two days (I take it at night). I can't pinpoint these to resveratrol 100% but timing of the syptoms coincide.
I think this goes to show that resveratrol dosage increase, even when modest, does create noticeable differences; which gives a hint on how powerful effects it can have on the body. Maybe my body is warning me to be careful.
With other supplements I use, such as silymarin, choline, burdock root, ellagic acid, etc., I've experienced no noticeable changes even when I tripled the amounts.
I think I'll step down to 500 mg and see what happens. I believe everyone has an "ideal" dosage, and I'm trying to find mine.
I am now taking 15 grams of Resveratrol in an emulsion of coconut oil, grapefruit juice, Bioperine, sodium ascorbate, aspirin, Vitamin E and 12.5 grams Curcumin which has been processed long and hard enough to form nano-drops of oil in the emusions, based on patents I've read. 20 minutes before taking the emulsion I take 10 mg. Bioperine and two adult aspirins with grapefruit juice. I take another aspirin and another Bioperine with the emulsion. I had some real problems with Quercetin and Resveratrol but since I dropped off the Quercetin, I'm having nothing but good effects from what should be highly available Resveratrol and Curcumin. I sleep like a teenager, I feel very good, my mood is excellent. My prostate cancer, which appears to have been slowly growing in me for 10-14 years and giving me very painful symptoms all during that time, is now asymptomatic. In a few days I up the amount of Resveratrol to 20 grams.
Oh yes. I'm also using Resveratrol buccally from arising to Noon. I'm waiting for my Resveratrol lozenges to arrive in a week. I know the power of buccal delivery of Resveratrol and having lozenges to suck on instead of just coating my cheeks and gums with Resveratrol is exciting.
With me, it appears the more you take, the less side effects. Or, I've habituated to the effects of the Resveratrol.
I am glad that removing quercetin from your regimen eliminated your adverse symptoms.
Twenty grams of resveratrol approaches voodoo black magic. The most I've heard of someone taking (other than an acute dose,) is 7 grams a day. There was a rodent study that showed kidney lesions appearing at a dose that might be the human equivalent of 15 grams a day, but it took three times as much before any deaths were noted. You are entering uncharted territory. Do be careful my friend.
Agreed here, approaching an ounce daily of any concentrated supplement like Resveratrol, for a prolonged period may contradict the intended effect. If this does work for you, and I think it will, provided you know when to decrease dosage, please document and verify its success.